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. Author manuscript; available in PMC: 2017 Oct 6.
Published in final edited form as: Cell. 2016 Sep 29;167(2):419–432.e16. doi: 10.1016/j.cell.2016.09.011

Figure 7. SynNotch Circuits Allow Versatile Reprogramming of T cells to Monitor and Selectively Modulate Their Microenvironment.

Figure 7

(A) synNotch receptors can drive diverse behaviors in primary human T cells. We show that synNotch receptors can drive custom cytokine production profiles, effectively deliver non-native therapeutics, and control T cell differentiation, all in an antigen-dependent and T cell activation independent manner.

(B) synNotch are sufficient to target T cells in vivo to locally produce a therapeutic payload. Future T cell therapies could utilize synNotch receptors to target T cells to disease-related or tissue-specific antigens for local delivery of therapeutics that are ineffective or toxic as systemically administered agents in humans.