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. 2016 Aug 2;34(11):1075–1086. doi: 10.1007/s40273-016-0432-x
The causal effects of health conditions on cost can be estimated using genetic variants as instruments for health conditions.
This form of analysis—Mendelian randomization—can identify causal effects because genetic variants that influence health status may be unrelated to known and unknown confounders.
Datasets with linked genotypic and resource use information are now becoming available and will facilitate this form of analysis.