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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Biomaterials. 2016 Sep 30;111:66–79. doi: 10.1016/j.biomaterials.2016.09.024

Figure 10. Effects of switch between static and dynamic culture on structure and function of hPSC-CM cardiobundles.

Figure 10

(A) Representative cross-section images of human cardiobundles cultured for 2 weeks in static or dynamic conditions stained with F-actin (green) and nuclei (DAPI, blue). (B–C) Quantification of areas (B) and nuclei counts (C) from cross-sections of human cardiobundles shown relative to static group (n = 14–17 cardiobundles per group from 4 differentiations). (D–E) Quantification of twitch force amplitude (D) and CV (E) in human cardiobundles relative to static group (n > 25 cardiobundles per group from 6–7 differentiations). *, p < 0.05 vs. static; &, p < 0.05 vs. corresponding non-rapamycin group.