Skip to main content
. 2016 Oct 20;4:e2542. doi: 10.7717/peerj.2542

Figure 9. Illustration of the pathological pathway of ER-α associated HPN.

Figure 9

In this PN circle represent standard places which explained the behavior of ligands (IGF-1, EGF), membrane and hormonal receptors (IGF-1R, EGFR and ER-α) and TSGs (BRCA1, p53 and Mdm2) and the squares represent continuous transitions to demonstrate the processes of activation, inhibition and phosphorylation. Directed arrows represent activation signal coming from standard places and going towards continuous transitions. Inhibitory arcs represent inhibition signal which stops signal coming from standard places towards continuous transitions. The rate of mass action for all continuous transitions is taken as 1. The ligands (IGF-1, EGF) and the membrane receptors (IGF-1R/EGFR) are given with an arbitrary token number of 5.