Table 2. Comparison of expression levels of entities of both homeostasis and disease ER-α associated HPN simulation with respect to literature search.

The positive sign (+) indicates the up-regulate expression, double positive (++) sign indicates the over-expression and a negative sign (−) indicates the down-regulate the expression levels of entities.

Genes	Homeostasis		Disease
	Literature	Simulation	Literature	Simulation
Ligands IGF-1/EGF	− Surmacz & Bartucci (2004)	−	+ Kang et al. (2012a)	+
Receptors IGF-1R/ EGFR	− Surmacz & Bartucci (2004)	−	++ Ouban et al. (2003); Surmacz & Bartucci (2004); Taunk et al., (2010)	+
ER-α	− Zhang et al. (2014)	−	++ Bailey et al. (2012); Surmacz & Bartucci (2004); Liu et al. (2006)	++
BRCA1	+ Ma et al. (2010)	+	− Kang et al. (2012a); Rosen et al. (2003)	−
p53	+ Berger et al. (2012); Miller et al. (2005)	+	− Angeloni et al. (2004); Bailey et al. 2012; Liu et al. (2009)	−
Mdm2	+ Berger et al. (2012)	++	− Kim, Burghardt & Barhoumi (2011)	−