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The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2016 Oct 21;291(43):22853. doi: 10.1074/jbc.A111.287433

IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation.

Jian-Ping Guo, Domenico Coppola, Jin Q Cheng
PMCID: PMC5077228  PMID: 27825091

VOLUME 286 (2011) PAGES 37389–37398

This article has been withdrawn by the authors. The same data were used to represent different experimental conditions. Specifically, the Myc-IKBKE immunoblot from Fig. 4B was reused as the Myc-IKBKE immunoblot in Fig. 4C. The IKBKE immunoblot from Ikbke−/− MEFs treated with EGF was reused in the IKBKE panel from Ikbke−/− MEFs treated with insulin in supplemental Fig. S5A. In supplemental Fig. S5B, the pAkt-T308 immunoblot from Ikbke−/− MEFs treated with glucose was reused in the pAkt-T308 panel from wild type MEFs treated with amino acid. The authors state that the overall conclusions of the study are not affected.


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