Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1997 Jan 1;99(1):3–8. doi: 10.1172/JCI119129

The biology of PECAM-1.

P J Newman 1
PMCID: PMC507759  PMID: 9011572

Full Text

The Full Text of this article is available as a PDF (157.4 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahmad S., Banville D., Zhao Z., Fischer E. H., Shen S. H. A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2197–2201. doi: 10.1073/pnas.90.6.2197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Albelda S. M., Muller W. A., Buck C. A., Newman P. J. Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule. J Cell Biol. 1991 Sep;114(5):1059–1068. doi: 10.1083/jcb.114.5.1059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Albelda S. M., Oliver P. D., Romer L. H., Buck C. A. EndoCAM: a novel endothelial cell-cell adhesion molecule. J Cell Biol. 1990 Apr;110(4):1227–1237. doi: 10.1083/jcb.110.4.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Behar E., Chao N. J., Hiraki D. D., Krishnaswamy S., Brown B. W., Zehnder J. L., Grumet F. C. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. N Engl J Med. 1996 Feb 1;334(5):286–291. doi: 10.1056/NEJM199602013340502. [DOI] [PubMed] [Google Scholar]
  5. Berman M. E., Muller W. A. Ligation of platelet/endothelial cell adhesion molecule 1 (PECAM-1/CD31) on monocytes and neutrophils increases binding capacity of leukocyte CR3 (CD11b/CD18). J Immunol. 1995 Jan 1;154(1):299–307. [PubMed] [Google Scholar]
  6. Berman M. E., Xie Y., Muller W. A. Roles of platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) in natural killer cell transendothelial migration and beta 2 integrin activation. J Immunol. 1996 Feb 15;156(4):1515–1524. [PubMed] [Google Scholar]
  7. Bogen S., Pak J., Garifallou M., Deng X., Muller W. A. Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo. J Exp Med. 1994 Mar 1;179(3):1059–1064. doi: 10.1084/jem.179.3.1059. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Buckley C. D., Doyonnas R., Newton J. P., Blystone S. D., Brown E. J., Watt S. M., Simmons D. L. Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1. J Cell Sci. 1996 Feb;109(Pt 2):437–445. doi: 10.1242/jcs.109.2.437. [DOI] [PubMed] [Google Scholar]
  9. DeLisser H. M., Chilkotowsky J., Yan H. C., Daise M. L., Buck C. A., Albelda S. M. Deletions in the cytoplasmic domain of platelet-endothelial cell adhesion molecule-1 (PECAM-1, CD31) result in changes in ligand binding properties. J Cell Biol. 1994 Jan;124(1-2):195–203. doi: 10.1083/jcb.124.1.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. DeLisser H. M., Yan H. C., Newman P. J., Muller W. A., Buck C. A., Albelda S. M. Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans. J Biol Chem. 1993 Jul 25;268(21):16037–16046. [PubMed] [Google Scholar]
  11. Feng G. S., Hui C. C., Pawson T. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science. 1993 Mar 12;259(5101):1607–1611. doi: 10.1126/science.8096088. [DOI] [PubMed] [Google Scholar]
  12. Feng G. S., Pawson T. Phosphotyrosine phosphatases with SH2 domains: regulators of signal transduction. Trends Genet. 1994 Feb;10(2):54–58. doi: 10.1016/0168-9525(94)90149-x. [DOI] [PubMed] [Google Scholar]
  13. Freeman R. M., Jr, Plutzky J., Neel B. G. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11239–11243. doi: 10.1073/pnas.89.23.11239. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Goyert S. M., Ferrero E. M., Seremetis S. V., Winchester R. J., Silver J., Mattison A. C. Biochemistry and expression of myelomonocytic antigens. J Immunol. 1986 Dec 15;137(12):3909–3914. [PubMed] [Google Scholar]
  15. Gumina R. J., Kirschbaum N. E., Rao P. N., vanTuinen P., Newman P. J. The human PECAM1 gene maps to 17q23. Genomics. 1996 Jun 1;34(2):229–232. doi: 10.1006/geno.1996.0272. [DOI] [PubMed] [Google Scholar]
  16. Kirschbaum N. E., Gumina R. J., Newman P. J. Organization of the gene for human platelet/endothelial cell adhesion molecule-1 shows alternatively spliced isoforms and a functionally complex cytoplasmic domain. Blood. 1994 Dec 15;84(12):4028–4037. [PubMed] [Google Scholar]
  17. Kuhné M. R., Pawson T., Lienhard G. E., Feng G. S. The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem. 1993 Jun 5;268(16):11479–11481. [PubMed] [Google Scholar]
  18. Leavesley D. I., Oliver J. M., Swart B. W., Berndt M. C., Haylock D. N., Simmons P. J. Signals from platelet/endothelial cell adhesion molecule enhance the adhesive activity of the very late antigen-4 integrin of human CD34+ hemopoietic progenitor cells. J Immunol. 1994 Nov 15;153(10):4673–4683. [PubMed] [Google Scholar]
  19. Lechleider R. J., Freeman R. M., Jr, Neel B. G. Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J Biol Chem. 1993 Jun 25;268(18):13434–13438. [PubMed] [Google Scholar]
  20. Liao F., Huynh H. K., Eiroa A., Greene T., Polizzi E., Muller W. A. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. J Exp Med. 1995 Nov 1;182(5):1337–1343. doi: 10.1084/jem.182.5.1337. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Lu T. T., Yan L. G., Madri J. A. Integrin engagement mediates tyrosine dephosphorylation on platelet-endothelial cell adhesion molecule 1. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11808–11813. doi: 10.1073/pnas.93.21.11808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Modderman P. W., von dem Borne A. E., Sonnenberg A. Tyrosine phosphorylation of P-selectin in intact platelets and in a disulphide-linked complex with immunoprecipitated pp60c-src. Biochem J. 1994 May 1;299(Pt 3):613–621. doi: 10.1042/bj2990613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Muller W. A., Berman M. E., Newman P. J., DeLisser H. M., Albelda S. M. A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). J Exp Med. 1992 May 1;175(5):1401–1404. doi: 10.1084/jem.175.5.1401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Muller W. A., Ratti C. M., McDonnell S. L., Cohn Z. A. A human endothelial cell-restricted, externally disposed plasmalemmal protein enriched in intercellular junctions. J Exp Med. 1989 Aug 1;170(2):399–414. doi: 10.1084/jem.170.2.399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Muller W. A., Weigl S. A., Deng X., Phillips D. M. PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med. 1993 Aug 1;178(2):449–460. doi: 10.1084/jem.178.2.449. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Murohara T., Delyani J. A., Albelda S. M., Lefer A. M. Blockade of platelet endothelial cell adhesion molecule-1 protects against myocardial ischemia and reperfusion injury in cats. J Immunol. 1996 May 1;156(9):3550–3557. [PubMed] [Google Scholar]
  27. Newman P. J., Berndt M. C., Gorski J., White G. C., 2nd, Lyman S., Paddock C., Muller W. A. PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily. Science. 1990 Mar 9;247(4947):1219–1222. doi: 10.1126/science.1690453. [DOI] [PubMed] [Google Scholar]
  28. Ohto H., Maeda H., Shibata Y., Chen R. F., Ozaki Y., Higashihara M., Takeuchi A., Tohyama H. A novel leukocyte differentiation antigen: two monoclonal antibodies TM2 and TM3 define a 120-kd molecule present on neutrophils, monocytes, platelets, and activated lymphoblasts. Blood. 1985 Oct;66(4):873–881. [PubMed] [Google Scholar]
  29. Piali L., Albelda S. M., Baldwin H. S., Hammel P., Gisler R. H., Imhof B. A. Murine platelet endothelial cell adhesion molecule (PECAM-1)/CD31 modulates beta 2 integrins on lymphokine-activated killer cells. Eur J Immunol. 1993 Oct;23(10):2464–2471. doi: 10.1002/eji.1830231013. [DOI] [PubMed] [Google Scholar]
  30. Piali L., Hammel P., Uherek C., Bachmann F., Gisler R. H., Dunon D., Imhof B. A. CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium. J Cell Biol. 1995 Jul;130(2):451–460. doi: 10.1083/jcb.130.2.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Schimmenti L. A., Yan H. C., Madri J. A., Albelda S. M. Platelet endothelial cell adhesion molecule, PECAM-1, modulates cell migration. J Cell Physiol. 1992 Nov;153(2):417–428. doi: 10.1002/jcp.1041530222. [DOI] [PubMed] [Google Scholar]
  32. Simmons D. L., Walker C., Power C., Pigott R. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J Exp Med. 1990 Jun 1;171(6):2147–2152. doi: 10.1084/jem.171.6.2147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Stockinger H., Gadd S. J., Eher R., Majdic O., Schreiber W., Kasinrerk W., Strass B., Schnabl E., Knapp W. Molecular characterization and functional analysis of the leukocyte surface protein CD31. J Immunol. 1990 Dec 1;145(11):3889–3897. [PubMed] [Google Scholar]
  34. Stone R. L., Dixon J. E. Protein-tyrosine phosphatases. J Biol Chem. 1994 Dec 16;269(50):31323–31326. [PubMed] [Google Scholar]
  35. Streuli M. Protein tyrosine phosphatases in signaling. Curr Opin Cell Biol. 1996 Apr;8(2):182–188. doi: 10.1016/s0955-0674(96)80064-0. [DOI] [PubMed] [Google Scholar]
  36. Sun Q. H., DeLisser H. M., Zukowski M. M., Paddock C., Albelda S. M., Newman P. J. Individually distinct Ig homology domains in PECAM-1 regulate homophilic binding and modulate receptor affinity. J Biol Chem. 1996 May 10;271(19):11090–11098. doi: 10.1074/jbc.271.19.11090. [DOI] [PubMed] [Google Scholar]
  37. Tanaka Y., Albelda S. M., Horgan K. J., van Seventer G. A., Shimizu Y., Newman W., Hallam J., Newman P. J., Buck C. A., Shaw S. CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion. J Exp Med. 1992 Jul 1;176(1):245–253. doi: 10.1084/jem.176.1.245. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Vaporciyan A. A., DeLisser H. M., Yan H. C., Mendiguren I. I., Thom S. R., Jones M. L., Ward P. A., Albelda S. M. Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science. 1993 Dec 3;262(5139):1580–1582. doi: 10.1126/science.8248808. [DOI] [PubMed] [Google Scholar]
  39. Vogel W., Lammers R., Huang J., Ullrich A. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science. 1993 Mar 12;259(5101):1611–1614. doi: 10.1126/science.7681217. [DOI] [PubMed] [Google Scholar]
  40. Yan H. C., Baldwin H. S., Sun J., Buck C. A., Albelda S. M., DeLisser H. M. Alternative splicing of a specific cytoplasmic exon alters the binding characteristics of murine platelet/endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem. 1995 Oct 6;270(40):23672–23680. doi: 10.1074/jbc.270.40.23672. [DOI] [PubMed] [Google Scholar]
  41. Yan H. C., Pilewski J. M., Zhang Q., DeLisser H. M., Romer L., Albelda S. M. Localization of multiple functional domains on human PECAM-1 (CD31) by monoclonal antibody epitope mapping. Cell Adhes Commun. 1995 Feb;3(1):45–66. doi: 10.3109/15419069509081277. [DOI] [PubMed] [Google Scholar]
  42. Zehnder J. L., Shatsky M., Leung L. L., Butcher E. C., McGregor J. L., Levitt L. J. Involvement of CD31 in lymphocyte-mediated immune responses: importance of the membrane-proximal immunoglobulin domain and identification of an inhibiting CD31 peptide. Blood. 1995 Mar 1;85(5):1282–1288. [PubMed] [Google Scholar]
  43. van Mourik J. A., Leeksma O. C., Reinders J. H., de Groot P. G., Zandbergen-Spaargaren J. Vascular endothelial cells synthesize a plasma membrane protein indistinguishable from the platelet membrane glycoprotein IIa. J Biol Chem. 1985 Sep 15;260(20):11300–11306. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES