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. 2016 Apr 20;7(22):33004–33015. doi: 10.18632/oncotarget.8844

Figure 2. Inhibition of Hedgehog pathway enhances the radiosensitivity both in radio-resistant leukemia and drug-resistant leukemia cells.

Figure 2

A, B. Survival curves of HL60/ADR and HL60/RX cells after radiation. C, D. Cell apoptosis distribution showed that the percentage of apoptosis cells significantly increase in cells treated with LDE225 and radiation combined with control, RT alone and LDE225 alone. E, F. The highest increased in γ-H2AX expression was seen in HL60/ADR and HL60/RX cells treated with LDE225 and radiation.*, p<0.001 vs No inhibitor+RT. ×, p<0.001 vs vehicle-treated control group, radiation group, or LDE225 group. #, p<0.01 vs LDE225 group. Abbreviation: RT, radiation.