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. 2016 Apr 20;7(22):33025–33034. doi: 10.18632/oncotarget.8846

Figure 4. Preclinical orthotopic and lung metastasis mouse models using RM9-Luc-pIRES-KLK3 cells (n = 7).

Figure 4

A. Bioluminescence images in a representative orthotopic and lung metastasis mouse model. B. Tumor progression was monitored by evaluating serum PSA level (ng/mL) (i) and bioluminescence intensity (photos/s) (ii) on days 3, 7, 14, and 21 after RM9-Luc-pIRES-KLK3 was injected into the prostate. Error bars represent standard error of mean. Mean values were analyzed among groups. *p < 0.05 C. 18F-FDG PET images of orthotopic tumor-bearing mice at day 3 and day 14 after RM9-Luc-pIRES-KLK3 was injected into the prostate and tail vein D. Anatomical autoradiography images of the prostate and lung in the orthotopic prostate cancer model at days 3 and 14 after RM9-Luc-pIRES-KLK3 injection. In the metastasis model, micrometastatic points were sensitively detected on day 3 after RM9-Luc-pIRES-KLK3 injection.