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. 1997 Feb 15;99(4):565–569. doi: 10.1172/JCI119196

Regulation of bacterial virulence gene expression by the host environment.

D G Guiney 1
PMCID: PMC507835  PMID: 9045855

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alpuche Aranda C. M., Swanson J. A., Loomis W. P., Miller S. I. Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes. Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10079–10083. doi: 10.1073/pnas.89.21.10079. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bajaj V., Lucas R. L., Hwang C., Lee C. A. Co-ordinate regulation of Salmonella typhimurium invasion genes by environmental and regulatory factors is mediated by control of hilA expression. Mol Microbiol. 1996 Nov;22(4):703–714. doi: 10.1046/j.1365-2958.1996.d01-1718.x. [DOI] [PubMed] [Google Scholar]
  3. Buchmeier N. A., Libby S. J., Xu Y., Loewen P. C., Switala J., Guiney D. G., Fang F. C. DNA repair is more important than catalase for Salmonella virulence in mice. J Clin Invest. 1995 Mar;95(3):1047–1053. doi: 10.1172/JCI117750. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Caparon M. G., Geist R. T., Perez-Casal J., Scott J. R. Environmental regulation of virulence in group A streptococci: transcription of the gene encoding M protein is stimulated by carbon dioxide. J Bacteriol. 1992 Sep;174(17):5693–5701. doi: 10.1128/jb.174.17.5693-5701.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chen C. Y., Buchmeier N. A., Libby S., Fang F. C., Krause M., Guiney D. G. Central regulatory role for the RpoS sigma factor in expression of Salmonella dublin plasmid virulence genes. J Bacteriol. 1995 Sep;177(18):5303–5309. doi: 10.1128/jb.177.18.5303-5309.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Chen C. Y., Eckmann L., Libby S. J., Fang F. C., Okamoto S., Kagnoff M. F., Fierer J., Guiney D. G. Expression of Salmonella typhimurium rpoS and rpoS-dependent genes in the intracellular environment of eukaryotic cells. Infect Immun. 1996 Nov;64(11):4739–4743. doi: 10.1128/iai.64.11.4739-4743.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Dorman C. J., Chatfield S., Higgins C. F., Hayward C., Dougan G. Characterization of porin and ompR mutants of a virulent strain of Salmonella typhimurium: ompR mutants are attenuated in vivo. Infect Immun. 1989 Jul;57(7):2136–2140. doi: 10.1128/iai.57.7.2136-2140.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fang F. C., Libby S. J., Buchmeier N. A., Loewen P. C., Switala J., Harwood J., Guiney D. G. The alternative sigma factor katF (rpoS) regulates Salmonella virulence. Proc Natl Acad Sci U S A. 1992 Dec 15;89(24):11978–11982. doi: 10.1073/pnas.89.24.11978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Fields P. I., Swanson R. V., Haidaris C. G., Heffron F. Mutants of Salmonella typhimurium that cannot survive within the macrophage are avirulent. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5189–5193. doi: 10.1073/pnas.83.14.5189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Francis C. L., Ryan T. A., Jones B. D., Smith S. J., Falkow S. Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature. 1993 Aug 12;364(6438):639–642. doi: 10.1038/364639a0. [DOI] [PubMed] [Google Scholar]
  11. Galán J. E., Curtiss R., 3rd Cloning and molecular characterization of genes whose products allow Salmonella typhimurium to penetrate tissue culture cells. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6383–6387. doi: 10.1073/pnas.86.16.6383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Galán J. E. Molecular genetic bases of Salmonella entry into host cells. Mol Microbiol. 1996 Apr;20(2):263–271. doi: 10.1111/j.1365-2958.1996.tb02615.x. [DOI] [PubMed] [Google Scholar]
  13. Garcia-del Portillo F., Pucciarelli M. G., Jefferies W. A., Finlay B. B. Salmonella typhimurium induces selective aggregation and internalization of host cell surface proteins during invasion of epithelial cells. J Cell Sci. 1994 Jul;107(Pt 7):2005–2020. doi: 10.1242/jcs.107.7.2005. [DOI] [PubMed] [Google Scholar]
  14. García Véscovi E., Soncini F. C., Groisman E. A. Mg2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell. 1996 Jan 12;84(1):165–174. doi: 10.1016/s0092-8674(00)81003-x. [DOI] [PubMed] [Google Scholar]
  15. Grob P., Guiney D. G. In vitro binding of the Salmonella dublin virulence plasmid regulatory protein SpvR to the promoter regions of spvA and spvR. J Bacteriol. 1996 Apr;178(7):1813–1820. doi: 10.1128/jb.178.7.1813-1820.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Groisman E. A., Chiao E., Lipps C. J., Heffron F. Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proc Natl Acad Sci U S A. 1989 Sep;86(18):7077–7081. doi: 10.1073/pnas.86.18.7077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Guiney D. G., Fang F. C., Krause M., Libby S., Buchmeier N. A., Fierer J. Biology and clinical significance of virulence plasmids in Salmonella serovars. Clin Infect Dis. 1995 Oct;21 (Suppl 2):S146–S151. doi: 10.1093/clinids/21.supplement_2.s146. [DOI] [PubMed] [Google Scholar]
  18. Hale T. L. Genetic basis of virulence in Shigella species. Microbiol Rev. 1991 Jun;55(2):206–224. doi: 10.1128/mr.55.2.206-224.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Hengge-Aronis R. Back to log phase: sigma S as a global regulator in the osmotic control of gene expression in Escherichia coli. Mol Microbiol. 1996 Sep;21(5):887–893. doi: 10.1046/j.1365-2958.1996.511405.x. [DOI] [PubMed] [Google Scholar]
  20. Ji G., Beavis R. C., Novick R. P. Cell density control of staphylococcal virulence mediated by an octapeptide pheromone. Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12055–12059. doi: 10.1073/pnas.92.26.12055. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Johnston C., Pegues D. A., Hueck C. J., Lee A., Miller S. I. Transcriptional activation of Salmonella typhimurium invasion genes by a member of the phosphorylated response-regulator superfamily. Mol Microbiol. 1996 Nov;22(4):715–727. doi: 10.1046/j.1365-2958.1996.d01-1719.x. [DOI] [PubMed] [Google Scholar]
  22. Miller S. I., Kukral A. M., Mekalanos J. J. A two-component regulatory system (phoP phoQ) controls Salmonella typhimurium virulence. Proc Natl Acad Sci U S A. 1989 Jul;86(13):5054–5058. doi: 10.1073/pnas.86.13.5054. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Straley S. C., Perry R. D. Environmental modulation of gene expression and pathogenesis in Yersinia. Trends Microbiol. 1995 Aug;3(8):310–317. doi: 10.1016/s0966-842x(00)88960-x. [DOI] [PubMed] [Google Scholar]
  24. Swift S., Throup J. P., Williams P., Salmond G. P., Stewart G. S. Quorum sensing: a population-density component in the determination of bacterial phenotype. Trends Biochem Sci. 1996 Jun;21(6):214–219. [PubMed] [Google Scholar]
  25. Wooldridge K. G., Williams P. H. Iron uptake mechanisms of pathogenic bacteria. FEMS Microbiol Rev. 1993 Nov;12(4):325–348. doi: 10.1111/j.1574-6976.1993.tb00026.x. [DOI] [PubMed] [Google Scholar]
  26. Zhang J. P., Normark S. Induction of gene expression in Escherichia coli after pilus-mediated adherence. Science. 1996 Aug 30;273(5279):1234–1236. doi: 10.1126/science.273.5279.1234. [DOI] [PubMed] [Google Scholar]

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