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. 1997 Mar 1;99(5):822–826. doi: 10.1172/JCI119244

Therapeutic inhibition of carbohydrate-protein interactions in vivo.

J B Lowe 1, P A Ward 1
PMCID: PMC507887  PMID: 9062337

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albelda S. M., Smith C. W., Ward P. A. Adhesion molecules and inflammatory injury. FASEB J. 1994 May;8(8):504–512. [PubMed] [Google Scholar]
  2. Arbonés M. L., Ord D. C., Ley K., Ratech H., Maynard-Curry C., Otten G., Capon D. J., Tedder T. F. Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice. Immunity. 1994 Jul;1(4):247–260. doi: 10.1016/1074-7613(94)90076-0. [DOI] [PubMed] [Google Scholar]
  3. Bargatze R. F., Kurk S., Butcher E. C., Jutila M. A. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J Exp Med. 1994 Nov 1;180(5):1785–1792. doi: 10.1084/jem.180.5.1785. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Briggs J. B., Oda Y., Gilbert J. H., Schaefer M. E., Macher B. A. Peptides inhibit selectin-mediated cell adhesion in vitro, and neutrophil influx into inflammatory sites in vivo. Glycobiology. 1995 Sep;5(6):583–588. doi: 10.1093/glycob/5.6.583. [DOI] [PubMed] [Google Scholar]
  5. Buerke M., Weyrich A. S., Zheng Z., Gaeta F. C., Forrest M. J., Lefer A. M. Sialyl Lewisx-containing oligosaccharide attenuates myocardial reperfusion injury in cats. J Clin Invest. 1994 Mar;93(3):1140–1148. doi: 10.1172/JCI117066. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Doerschuk C. M., Beyers N., Coxson H. O., Wiggs B., Hogg J. C. Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lung. J Appl Physiol (1985) 1993 Jun;74(6):3040–3045. doi: 10.1152/jappl.1993.74.6.3040. [DOI] [PubMed] [Google Scholar]
  7. Flynn D. M., Buda A. J., Jeffords P. R., Lefer D. J. A sialyl Lewis(x)-containing carbohydrate reduces infarct size: role of selectins in myocardial reperfusion injury. Am J Physiol. 1996 Nov;271(5 Pt 2):H2086–H2096. doi: 10.1152/ajpheart.1996.271.5.H2086. [DOI] [PubMed] [Google Scholar]
  8. Hicke B. J., Watson S. R., Koenig A., Lynott C. K., Bargatze R. F., Chang Y. F., Ringquist S., Moon-McDermott L., Jennings S., Fitzwater T. DNA aptamers block L-selectin function in vivo. Inhibition of human lymphocyte trafficking in SCID mice. J Clin Invest. 1996 Dec 15;98(12):2688–2692. doi: 10.1172/JCI119092. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hynes R. O., Wagner D. D. Genetic manipulation of vascular adhesion molecules in mice. J Clin Invest. 1996 Nov 15;98(10):2193–2195. doi: 10.1172/JCI119027. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jacob G. S., Kirmaier C., Abbas S. Z., Howard S. C., Steininger C. N., Welply J. K., Scudder P. Binding of sialyl Lewis x to E-selectin as measured by fluorescence polarization. Biochemistry. 1995 Jan 31;34(4):1210–1217. doi: 10.1021/bi00004a014. [DOI] [PubMed] [Google Scholar]
  11. Johnson B. A., Haines G. K., Harlow L. A., Koch A. E. Adhesion molecule expression in human synovial tissue. Arthritis Rheum. 1993 Feb;36(2):137–146. doi: 10.1002/art.1780360203. [DOI] [PubMed] [Google Scholar]
  12. Jutila M. A., Rott L., Berg E. L., Butcher E. C. Function and regulation of the neutrophil MEL-14 antigen in vivo: comparison with LFA-1 and MAC-1. J Immunol. 1989 Nov 15;143(10):3318–3324. [PubMed] [Google Scholar]
  13. Konstantopoulos K., McIntire L. V. Effects of fluid dynamic forces on vascular cell adhesion. J Clin Invest. 1996 Dec 15;98(12):2661–2665. doi: 10.1172/JCI119088. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Lefer A. M., Weyrich A. S., Buerke M. Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res. 1994 Mar;28(3):289–294. doi: 10.1093/cvr/28.3.289. [DOI] [PubMed] [Google Scholar]
  15. Malý P., Thall A., Petryniak B., Rogers C. E., Smith P. L., Marks R. M., Kelly R. J., Gersten K. M., Cheng G., Saunders T. L. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell. 1996 Aug 23;86(4):643–653. doi: 10.1016/s0092-8674(00)80137-3. [DOI] [PubMed] [Google Scholar]
  16. McEver R. P., Moore K. L., Cummings R. D. Leukocyte trafficking mediated by selectin-carbohydrate interactions. J Biol Chem. 1995 May 12;270(19):11025–11028. doi: 10.1074/jbc.270.19.11025. [DOI] [PubMed] [Google Scholar]
  17. Mizgerd J. P., Meek B. B., Kutkoski G. J., Bullard D. C., Beaudet A. L., Doerschuk C. M. Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungs. J Exp Med. 1996 Aug 1;184(2):639–645. doi: 10.1084/jem.184.2.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mulligan M. S., Lowe J. B., Larsen R. D., Paulson J., Zheng Z. L., DeFrees S., Maemura K., Fukuda M., Ward P. A. Protective effects of sialylated oligosaccharides in immune complex-induced acute lung injury. J Exp Med. 1993 Aug 1;178(2):623–631. doi: 10.1084/jem.178.2.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Mulligan M. S., Miyasaka M., Suzuki Y., Kawashima H., Iizuka M., Hasegawa A., Kiso M., Warner R. L., Ward P. A., Suzuki T. Anti-inflammatory effects of sulfatides in selectin-dependent acute lung injury. Int Immunol. 1995 Jul;7(7):1107–1113. doi: 10.1093/intimm/7.7.1107. [DOI] [PubMed] [Google Scholar]
  20. Mulligan M. S., Miyasaka M., Tamatani T., Jones M. L., Ward P. A. Requirements for L-selectin in neutrophil-mediated lung injury in rats. J Immunol. 1994 Jan 15;152(2):832–840. [PubMed] [Google Scholar]
  21. Mulligan M. S., Paulson J. C., De Frees S., Zheng Z. L., Lowe J. B., Ward P. A. Protective effects of oligosaccharides in P-selectin-dependent lung injury. Nature. 1993 Jul 8;364(6433):149–151. doi: 10.1038/364149a0. [DOI] [PubMed] [Google Scholar]
  22. Mulligan M. S., Polley M. J., Bayer R. J., Nunn M. F., Paulson J. C., Ward P. A. Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140). J Clin Invest. 1992 Oct;90(4):1600–1607. doi: 10.1172/JCI116029. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Mulligan M. S., Varani J., Dame M. K., Lane C. L., Smith C. W., Anderson D. C., Ward P. A. Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest. 1991 Oct;88(4):1396–1406. doi: 10.1172/JCI115446. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Mulligan M. S., Watson S. R., Fennie C., Ward P. A. Protective effects of selectin chimeras in neutrophil-mediated lung injury. J Immunol. 1993 Dec 1;151(11):6410–6417. [PubMed] [Google Scholar]
  25. Nelson R. M., Cecconi O., Roberts W. G., Aruffo A., Linhardt R. J., Bevilacqua M. P. Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood. 1993 Dec 1;82(11):3253–3258. [PubMed] [Google Scholar]
  26. Oldenburg K. R., Loganathan D., Goldstein I. J., Schultz P. G., Gallop M. A. Peptide ligands for a sugar-binding protein isolated from a random peptide library. Proc Natl Acad Sci U S A. 1992 Jun 15;89(12):5393–5397. doi: 10.1073/pnas.89.12.5393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Phillips M. L., Schwartz B. R., Etzioni A., Bayer R., Ochs H. D., Paulson J. C., Harlan J. M. Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2. J Clin Invest. 1995 Dec;96(6):2898–2906. doi: 10.1172/JCI118361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rao B. N., Anderson M. B., Musser J. H., Gilbert J. H., Schaefer M. E., Foxall C., Brandley B. K. Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with anti-inflammatory activity. J Biol Chem. 1994 Aug 5;269(31):19663–19666. [PubMed] [Google Scholar]
  29. Tojo S. J., Yokota S., Koike H., Schultz J., Hamazume Y., Misugi E., Yamada K., Hayashi M., Paulson J. C., Morooka S. Reduction of rat myocardial ischemia and reperfusion injury by sialyl Lewis x oligosaccharide and anti-rat P-selectin antibodies. Glycobiology. 1996 Jun;6(4):463–469. doi: 10.1093/glycob/6.4.463. [DOI] [PubMed] [Google Scholar]
  30. Varki A. Selectin ligands: will the real ones please stand up? J Clin Invest. 1997 Jan 15;99(2):158–162. doi: 10.1172/JCI119142. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Walcheck B., Moore K. L., McEver R. P., Kishimoto T. K. Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro. J Clin Invest. 1996 Sep 1;98(5):1081–1087. doi: 10.1172/JCI118888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Ward P. A. Adhesion molecule knockouts: one step forward and one step backward. J Clin Invest. 1995 Apr;95(4):1425–1425. doi: 10.1172/JCI117810. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Watson S. R., Fennie C., Lasky L. A. Neutrophil influx into an inflammatory site inhibited by a soluble homing receptor-IgG chimaera. Nature. 1991 Jan 10;349(6305):164–167. doi: 10.1038/349164a0. [DOI] [PubMed] [Google Scholar]
  34. Zhang R. L., Chopp M., Zhang Z. G., Phillips M. L., Rosenbloom C. L., Cruz R., Manning A. E-selectin in focal cerebral ischemia and reperfusion in the rat. J Cereb Blood Flow Metab. 1996 Nov;16(6):1126–1136. doi: 10.1097/00004647-199611000-00006. [DOI] [PubMed] [Google Scholar]
  35. Zimmerman G. A., McIntyre T. M., Prescott S. M. Adhesion and signaling in vascular cell--cell interactions. J Clin Invest. 1996 Oct 15;98(8):1699–1702. doi: 10.1172/JCI118967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. von Andrian U. H., Chambers J. D., McEvoy L. M., Bargatze R. F., Arfors K. E., Butcher E. C. Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7538–7542. doi: 10.1073/pnas.88.17.7538. [DOI] [PMC free article] [PubMed] [Google Scholar]

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