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. 1997 Mar 15;99(6):1147–1148. doi: 10.1172/JCI119268

Antiinflammatory potential of lipoxygenase-derived eicosanoids: a molecular switch at 5 and 15 positions?

C N Serhan, J M Drazen
PMCID: PMC507925  PMID: 9077519

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brungs M., Rådmark O., Samuelsson B., Steinhilber D. Sequential induction of 5-lipoxygenase gene expression and activity in Mono Mac 6 cells by transforming growth factor beta and 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1995 Jan 3;92(1):107–111. doi: 10.1073/pnas.92.1.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clària J., Serhan C. N. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9475–9479. doi: 10.1073/pnas.92.21.9475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Ferrante J. V., Huang Z. H., Nandoskar M., Hii C. S., Robinson B. S., Rathjen D. A., Poulos A., Morris C. P., Ferrante A. Altered responses of human macrophages to lipopolysaccharide by hydroperoxy eicosatetraenoic acid, hydroxy eicosatetraenoic acid, and arachidonic acid. Inhibition of tumor necrosis factor production. J Clin Invest. 1997 Mar 15;99(6):1445–1452. doi: 10.1172/JCI119303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Hiltunen T., Luoma J., Nikkari T., Ylä-Herttuala S. Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions. Circulation. 1995 Dec 1;92(11):3297–3303. doi: 10.1161/01.cir.92.11.3297. [DOI] [PubMed] [Google Scholar]
  5. Nassar G. M., Morrow J. D., Roberts L. J., 2nd, Lakkis F. G., Badr K. F. Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes. J Biol Chem. 1994 Nov 4;269(44):27631–27634. [PubMed] [Google Scholar]
  6. Serhan C. N., Haeggström J. Z., Leslie C. C. Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J. 1996 Aug;10(10):1147–1158. doi: 10.1096/fasebj.10.10.8751717. [DOI] [PubMed] [Google Scholar]
  7. Serhan C. N. Lipoxin biosynthesis and its impact in inflammatory and vascular events. Biochim Biophys Acta. 1994 Apr 14;1212(1):1–25. doi: 10.1016/0005-2760(94)90185-6. [DOI] [PubMed] [Google Scholar]
  8. Serhan C. N., Maddox J. F., Petasis N. A., Akritopoulou-Zanze I., Papayianni A., Brady H. R., Colgan S. P., Madara J. L. Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry. 1995 Nov 7;34(44):14609–14615. doi: 10.1021/bi00044a041. [DOI] [PubMed] [Google Scholar]
  9. Vanderhoek J. Y., Bryant R. W., Bailey J. M. Inhibition of leukotriene biosynthesis by the leukocyte product 15-hydroxy-5,8,11,13-eicosatetraenoic acid. J Biol Chem. 1980 Nov 10;255(21):10064–10066. [PubMed] [Google Scholar]

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