Skip to main content
NCBI home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1997 Mar 15;99(6):1153–1157. doi: 10.1172/JCI119270

Yersinia proteins that target host cell signaling pathways.

M Fällman 1, C Persson 1, H Wolf-Watz 1
PMCID: PMC507927  PMID: 9077521

Full Text

The Full Text of this article is available as a PDF (229.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersson K., Carballeira N., Magnusson K. E., Persson C., Stendahl O., Wolf-Watz H., Fällman M. YopH of Yersinia pseudotuberculosis interrupts early phosphotyrosine signalling associated with phagocytosis. Mol Microbiol. 1996 Jun;20(5):1057–1069. doi: 10.1111/j.1365-2958.1996.tb02546.x. [DOI] [PubMed] [Google Scholar]
  2. Burnham M. R., Harte M. T., Richardson A., Parsons J. T., Bouton A. H. The identification of p130cas-binding proteins and their role in cellular transformation. Oncogene. 1996 Jun 6;12(11):2467–2472. [PubMed] [Google Scholar]
  3. Coburn J., Wyatt R. T., Iglewski B. H., Gill D. M. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S. J Biol Chem. 1989 May 25;264(15):9004–9008. [PubMed] [Google Scholar]
  4. Forsberg A., Rosqvist R., Wolf-Watz H. Regulation and polarized transfer of the Yersinia outer proteins (Yops) involved in antiphagocytosis. Trends Microbiol. 1994 Jan;2(1):14–19. doi: 10.1016/0966-842x(94)90339-5. [DOI] [PubMed] [Google Scholar]
  5. Fällman M., Andersson K., Håkansson S., Magnusson K. E., Stendahl O., Wolf-Watz H. Yersinia pseudotuberculosis inhibits Fc receptor-mediated phagocytosis in J774 cells. Infect Immun. 1995 Aug;63(8):3117–3124. doi: 10.1128/iai.63.8.3117-3124.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Galyov E. E., Håkansson S., Forsberg A., Wolf-Watz H. A secreted protein kinase of Yersinia pseudotuberculosis is an indispensable virulence determinant. Nature. 1993 Feb 25;361(6414):730–732. doi: 10.1038/361730a0. [DOI] [PubMed] [Google Scholar]
  7. Guan K. L., Dixon J. E. Protein tyrosine phosphatase activity of an essential virulence determinant in Yersinia. Science. 1990 Aug 3;249(4968):553–556. doi: 10.1126/science.2166336. [DOI] [PubMed] [Google Scholar]
  8. Haimovich B., Regan C., DiFazio L., Ginalis E., Ji P., Purohit U., Rowley R. B., Bolen J., Greco R. The FcgammaRII receptor triggers pp125FAK phosphorylation in platelets. J Biol Chem. 1996 Jul 5;271(27):16332–16337. doi: 10.1074/jbc.271.27.16332. [DOI] [PubMed] [Google Scholar]
  9. Hermant D., Ménard R., Arricau N., Parsot C., Popoff M. Y. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Mol Microbiol. 1995 Aug;17(4):781–789. doi: 10.1111/j.1365-2958.1995.mmi_17040781.x. [DOI] [PubMed] [Google Scholar]
  10. Håkansson S., Bergman T., Vanooteghem J. C., Cornelis G., Wolf-Watz H. YopB and YopD constitute a novel class of Yersinia Yop proteins. Infect Immun. 1993 Jan;61(1):71–80. doi: 10.1128/iai.61.1.71-80.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Håkansson S., Galyov E. E., Rosqvist R., Wolf-Watz H. The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane. Mol Microbiol. 1996 May;20(3):593–603. doi: 10.1046/j.1365-2958.1996.5251051.x. [DOI] [PubMed] [Google Scholar]
  12. Håkansson S., Schesser K., Persson C., Galyov E. E., Rosqvist R., Homblé F., Wolf-Watz H. The YopB protein of Yersinia pseudotuberculosis is essential for the translocation of Yop effector proteins across the target cell plasma membrane and displays a contact-dependent membrane disrupting activity. EMBO J. 1996 Nov 1;15(21):5812–5823. [PMC free article] [PubMed] [Google Scholar]
  13. Isberg R. R., Tran Van Nhieu G. Binding and internalization of microorganisms by integrin receptors. Trends Microbiol. 1994 Jan;2(1):10–14. doi: 10.1016/0966-842x(94)90338-7. [DOI] [PubMed] [Google Scholar]
  14. Kulich S. M., Yahr T. L., Mende-Mueller L. M., Barbieri J. T., Frank D. W. Cloning the structural gene for the 49-kDa form of exoenzyme S (exoS) from Pseudomonas aeruginosa strain 388. J Biol Chem. 1994 Apr 8;269(14):10431–10437. [PubMed] [Google Scholar]
  15. Miyamoto S., Teramoto H., Coso O. A., Gutkind J. S., Burbelo P. D., Akiyama S. K., Yamada K. M. Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol. 1995 Nov;131(3):791–805. doi: 10.1083/jcb.131.3.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nakamura T. Y., Yamamoto I., Nishitani H., Matozaki T., Suzuki T., Wakabayashi S., Shigekawa M., Goshima K. Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: synergistic role of phosphotyrosine and intracellular Ca2+ concentration. J Cell Biol. 1995 Oct;131(2):509–524. doi: 10.1083/jcb.131.2.509. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Nojima Y., Morino N., Mimura T., Hamasaki K., Furuya H., Sakai R., Sato T., Tachibana K., Morimoto C., Yazaki Y. Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs. J Biol Chem. 1995 Jun 23;270(25):15398–15402. doi: 10.1074/jbc.270.25.15398. [DOI] [PubMed] [Google Scholar]
  18. Persson C., Nordfelth R., Holmström A., Håkansson S., Rosqvist R., Wolf-Watz H. Cell-surface-bound Yersinia translocate the protein tyrosine phosphatase YopH by a polarized mechanism into the target cell. Mol Microbiol. 1995 Oct;18(1):135–150. doi: 10.1111/j.1365-2958.1995.mmi_18010135.x. [DOI] [PubMed] [Google Scholar]
  19. Petch L. A., Bockholt S. M., Bouton A., Parsons J. T., Burridge K. Adhesion-induced tyrosine phosphorylation of the p130 src substrate. J Cell Sci. 1995 Apr;108(Pt 4):1371–1379. doi: 10.1242/jcs.108.4.1371. [DOI] [PubMed] [Google Scholar]
  20. Petruzzelli L., Takami M., Herrera R. Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII. J Biol Chem. 1996 Mar 29;271(13):7796–7801. doi: 10.1074/jbc.271.13.7796. [DOI] [PubMed] [Google Scholar]
  21. Pettersson J., Nordfelth R., Dubinina E., Bergman T., Gustafsson M., Magnusson K. E., Wolf-Watz H. Modulation of virulence factor expression by pathogen target cell contact. Science. 1996 Aug 30;273(5279):1231–1233. doi: 10.1126/science.273.5279.1231. [DOI] [PubMed] [Google Scholar]
  22. Polte T. R., Hanks S. K. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10678–10682. doi: 10.1073/pnas.92.23.10678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Richardson A., Parsons J. T. Signal transduction through integrins: a central role for focal adhesion kinase? Bioessays. 1995 Mar;17(3):229–236. doi: 10.1002/bies.950170309. [DOI] [PubMed] [Google Scholar]
  24. Richardson A., Parsons T. A mechanism for regulation of the adhesion-associated proteintyrosine kinase pp125FAK. Nature. 1996 Apr 11;380(6574):538–540. doi: 10.1038/380538a0. [DOI] [PubMed] [Google Scholar]
  25. Rosenshine I., Duronio V., Finlay B. B. Tyrosine protein kinase inhibitors block invasin-promoted bacterial uptake by epithelial cells. Infect Immun. 1992 Jun;60(6):2211–2217. doi: 10.1128/iai.60.6.2211-2217.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Rosqvist R., Forsberg A., Wolf-Watz H. Intracellular targeting of the Yersinia YopE cytotoxin in mammalian cells induces actin microfilament disruption. Infect Immun. 1991 Dec;59(12):4562–4569. doi: 10.1128/iai.59.12.4562-4569.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Rosqvist R., Håkansson S., Forsberg A., Wolf-Watz H. Functional conservation of the secretion and translocation machinery for virulence proteins of yersiniae, salmonellae and shigellae. EMBO J. 1995 Sep 1;14(17):4187–4195. doi: 10.1002/j.1460-2075.1995.tb00092.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Rosqvist R., Magnusson K. E., Wolf-Watz H. Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J. 1994 Feb 15;13(4):964–972. doi: 10.1002/j.1460-2075.1994.tb06341.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Ruckdeschel K., Roggenkamp A., Schubert S., Heesemann J. Differential contribution of Yersinia enterocolitica virulence factors to evasion of microbicidal action of neutrophils. Infect Immun. 1996 Mar;64(3):724–733. doi: 10.1128/iai.64.3.724-733.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Sakai R., Iwamatsu A., Hirano N., Ogawa S., Tanaka T., Mano H., Yazaki Y., Hirai H. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J. 1994 Aug 15;13(16):3748–3756. doi: 10.1002/j.1460-2075.1994.tb06684.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Sory M. P., Cornelis G. R. Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol Microbiol. 1994 Nov;14(3):583–594. doi: 10.1111/j.1365-2958.1994.tb02191.x. [DOI] [PubMed] [Google Scholar]
  32. Van Gijsegem F., Genin S., Boucher C. Conservation of secretion pathways for pathogenicity determinants of plant and animal bacteria. Trends Microbiol. 1993 Aug;1(5):175–180. doi: 10.1016/0966-842x(93)90087-8. [DOI] [PubMed] [Google Scholar]
  33. Vuori K., Ruoslahti E. Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix. J Biol Chem. 1995 Sep 22;270(38):22259–22262. doi: 10.1074/jbc.270.38.22259. [DOI] [PubMed] [Google Scholar]
  34. Zhang Z. Y., Clemens J. C., Schubert H. L., Stuckey J. A., Fischer M. W., Hume D. M., Saper M. A., Dixon J. E. Expression, purification, and physicochemical characterization of a recombinant Yersinia protein tyrosine phosphatase. J Biol Chem. 1992 Nov 25;267(33):23759–23766. [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES