Table 3.
Short- and long-term assessment of growth hormone secretion and growth hormone treatment
| Short -term assessment | Long-term assessment | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pt no. | Definitive treatment | Time interval (yr) | GH test | GH peak (μg/l) | GHD | GH treatment | GH treatment (yr) | Other CD treat-ment | GH test | GH peak (μg/l) | Time interval (yr) | GHD |
| 1 | 2 TSS + BA | – | – | – | – | No | – | RT | – | – | – | – |
| 2 | TSS + RT | 0.7 | Glucagon | 6.9 | Yes | Yes | 8.0 (AH) | – | ITT | 5.7 | 9.6 | No |
| 3 | TSS + RT | 0.7 | Glucagon | 6.4 | Yes | Yes | 3.5 (AH) | – | ITT | 11.4 | 8.6 | No |
| 4 | TSS + RT | 1.4 | ITT | 16.5 | No | Yes | 1.8 (AH) | – | ITT | 19.4 | 7.6 | No |
| 5 | TSS + RT | 0.3 | ITT | <1.0 | Yes | Yes | 7.1 (AH) | – | – | – | – | – |
| 6 | TSS + RT | – | – | – | – | No | – | BA | – | – | – | – |
| 7 | TSS | 0.2 | ITT | 12 | No | Yes (+Letrozole) | 1.5 (AH) | TSS + RT | – | – | – | – |
| 8 | TSS | 0.7 | Arginine | 1.1 | Yes | Yes | 9.9 (LA) | – | ITT | 0.9 | 10.0 | Yes |
| 9 | TSS | 0.7 | ITT | 18.3 | No | No | – | – | – | – | – | – |
| 10 | TSS | – | ITT | 3.8 | Yes | Yes | – | – | ITT | 10.1 | 17.0 | No |
| 11 | TSS | 0.2 | ITT | 4.0 | Yes | Yes | 7.7 (AH) | – | ITT | 8.2 | 8.1 | No |
| 12 | 2 TSS | 0.2 | ITT | <0.5 | Yes | Yes | 10.7 (AH) | – | ITT | 0.4 | 7.5 | Yes |
| 13 | TSS | 0.1 | ITT | 5.5 | Yes | No | – | – | – | – | – | – |
| 14 | TSS | 0.1 | ITT | 3.5 | Yes | Yes | 12.5 (AH/LA)a | – | – | – | – | – |
| 15 | TSS | – | – | – | Yes | Yes | – | RT | – | – | – | – |
| 16 | TSS | 0.3 | Glucagon | 16.1 | No | Yes | 3.4 (LA) | – | Glucagon | 0.4 | 3.8 | Yes |
| 17 | TSS | 0.8 | Glucagon | 9.5 | No | No | – | – | – | – | – | – |
| 18 | TSS | 0.5 | ITT | 2.6 | Yes | Yes | 1.6 (AH) | – | – | – | – | – |
| 19 | TSS | 0.8 | ITT | 1.6 | Yes | Yes (+GnRHa) | 3.4 | – | ITT | 0.9 | 4.6 | Yes |
| 20 | TSS | 0.5 | Glucagon | 5.3 | Yes | No | – | – | – | – | – | – |
| 21 | TSS | 0.9 | ITT | 0.6 | Yes | Yes | 4.3 (LA) | – | – | – | – | – |
TSS transsphenoidal surgery, 2 TSS two surgical procedures undertaken (see Table 2), RT external beam pituitary radiotherapy, BA bilateral adrenalectomy, Time interval time interval between the last definitive treatment inducing remission and GH testing, ITT insulin tolerance test, Time interval the interval between definitive treatment and GH testing, GnRHa gonadotrophin releasing hormone analogue, AH adult height, LA latest assessment
aGH therapy ongoing until peak bone mass achieved