Skip to main content
PMC home page
The Journal of Clinical Investigation logoLink to The Journal of Clinical Investigation
. 1997 Aug 1;100(3):493–495. doi: 10.1172/JCI119557

Perspectives series: host/pathogen interactions. Apoptosis in bacterial pathogenesis.

A Zychlinsky 1, P Sansonetti 1
PMCID: PMC508214  PMID: 9239394

Full Text

The Full Text of this article is available as a PDF (92.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alnemri E. S., Livingston D. J., Nicholson D. W., Salvesen G., Thornberry N. A., Wong W. W., Yuan J. Human ICE/CED-3 protease nomenclature. Cell. 1996 Oct 18;87(2):171–171. doi: 10.1016/s0092-8674(00)81334-3. [DOI] [PubMed] [Google Scholar]
  2. Alpuche-Aranda C. M., Racoosin E. L., Swanson J. A., Miller S. I. Salmonella stimulate macrophage macropinocytosis and persist within spacious phagosomes. J Exp Med. 1994 Feb 1;179(2):601–608. doi: 10.1084/jem.179.2.601. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chen L. M., Kaniga K., Galán J. E. Salmonella spp. are cytotoxic for cultured macrophages. Mol Microbiol. 1996 Sep;21(5):1101–1115. doi: 10.1046/j.1365-2958.1996.471410.x. [DOI] [PubMed] [Google Scholar]
  4. Chen Y., Smith M. R., Thirumalai K., Zychlinsky A. A bacterial invasin induces macrophage apoptosis by binding directly to ICE. EMBO J. 1996 Aug 1;15(15):3853–3860. [PMC free article] [PubMed] [Google Scholar]
  5. Chen Y., Zychlinsky A. Apoptosis induced by bacterial pathogens. Microb Pathog. 1994 Oct;17(4):203–212. doi: 10.1006/mpat.1994.1066. [DOI] [PubMed] [Google Scholar]
  6. Colotta F., Re F., Polentarutti N., Sozzani S., Mantovani A. Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood. 1992 Oct 15;80(8):2012–2020. [PubMed] [Google Scholar]
  7. Dinarello C. A. Biologic basis for interleukin-1 in disease. Blood. 1996 Mar 15;87(6):2095–2147. [PubMed] [Google Scholar]
  8. Dürrbaum-Landmann I., Gercken J., Flad H. D., Ernst M. Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis. Infect Immun. 1996 Dec;64(12):5384–5389. doi: 10.1128/iai.64.12.5384-5389.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Guzmán C. A., Domann E., Rohde M., Bruder D., Darji A., Weiss S., Wehland J., Chakraborty T., Timmis K. N. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Mol Microbiol. 1996 Apr;20(1):119–126. doi: 10.1111/j.1365-2958.1996.tb02494.x. [DOI] [PubMed] [Google Scholar]
  10. Hanna P. C., Acosta D., Collier R. J. On the role of macrophages in anthrax. Proc Natl Acad Sci U S A. 1993 Nov 1;90(21):10198–10201. doi: 10.1073/pnas.90.21.10198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hermant D., Ménard R., Arricau N., Parsot C., Popoff M. Y. Functional conservation of the Salmonella and Shigella effectors of entry into epithelial cells. Mol Microbiol. 1995 Aug;17(4):781–789. doi: 10.1111/j.1365-2958.1995.mmi_17040781.x. [DOI] [PubMed] [Google Scholar]
  12. Hofer M. F., Newell K., Duke R. C., Schlievert P. M., Freed J. H., Leung D. Y. Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis. Proc Natl Acad Sci U S A. 1996 May 28;93(11):5425–5430. doi: 10.1073/pnas.93.11.5425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hueck C. J., Hantman M. J., Bajaj V., Johnston C., Lee C. A., Miller S. I. Salmonella typhimurium secreted invasion determinants are homologous to Shigella Ipa proteins. Mol Microbiol. 1995 Nov;18(3):479–490. doi: 10.1111/j.1365-2958.1995.mmi_18030479.x. [DOI] [PubMed] [Google Scholar]
  14. Islam D., Veress B., Bardhan P. K., Lindberg A. A., Christensson B. In situ characterization of inflammatory responses in the rectal mucosae of patients with shigellosis. Infect Immun. 1997 Feb;65(2):739–749. doi: 10.1128/iai.65.2.739-749.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Kaniga K., Tucker S., Trollinger D., Galán J. E. Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells. J Bacteriol. 1995 Jul;177(14):3965–3971. doi: 10.1128/jb.177.14.3965-3971.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Kato S., Muro M., Akifusa S., Hanada N., Semba I., Fujii T., Kowashi Y., Nishihara T. Evidence for apoptosis of murine macrophages by Actinobacillus actinomycetemcomitans infection. Infect Immun. 1995 Oct;63(10):3914–3919. doi: 10.1128/iai.63.10.3914-3919.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Keane J., Balcewicz-Sablinska M. K., Remold H. G., Chupp G. L., Meek B. B., Fenton M. J., Kornfeld H. Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis. Infect Immun. 1997 Jan;65(1):298–304. doi: 10.1128/iai.65.1.298-304.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Khelef N., Guiso N. Induction of macrophage apoptosis by Bordetella pertussis adenylate cyclase-hemolysin. FEMS Microbiol Lett. 1995 Dec 1;134(1):27–32. doi: 10.1111/j.1574-6968.1995.tb07909.x. [DOI] [PubMed] [Google Scholar]
  19. Khelef N., Zychlinsky A., Guiso N. Bordetella pertussis induces apoptosis in macrophages: role of adenylate cyclase-hemolysin. Infect Immun. 1993 Oct;61(10):4064–4071. doi: 10.1128/iai.61.10.4064-4071.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Kochi S. K., Collier R. J. DNA fragmentation and cytolysis in U937 cells treated with diphtheria toxin or other inhibitors of protein synthesis. Exp Cell Res. 1993 Sep;208(1):296–302. doi: 10.1006/excr.1993.1249. [DOI] [PubMed] [Google Scholar]
  21. Laochumroonvorapong P., Paul S., Elkon K. B., Kaplan G. H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytes. Infect Immun. 1996 Feb;64(2):452–459. doi: 10.1128/iai.64.2.452-459.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Li P., Allen H., Banerjee S., Franklin S., Herzog L., Johnston C., McDowell J., Paskind M., Rodman L., Salfeld J. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell. 1995 Feb 10;80(3):401–411. doi: 10.1016/0092-8674(95)90490-5. [DOI] [PubMed] [Google Scholar]
  23. Lindgren S. W., Stojiljkovic I., Heffron F. Macrophage killing is an essential virulence mechanism of Salmonella typhimurium. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4197–4201. doi: 10.1073/pnas.93.9.4197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Mangan D. F., Welch G. R., Wahl S. M. Lipopolysaccharide, tumor necrosis factor-alpha, and IL-1 beta prevent programmed cell death (apoptosis) in human peripheral blood monocytes. J Immunol. 1991 Mar 1;146(5):1541–1546. [PubMed] [Google Scholar]
  25. Molloy A., Laochumroonvorapong P., Kaplan G. Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin. J Exp Med. 1994 Oct 1;180(4):1499–1509. doi: 10.1084/jem.180.4.1499. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Monack D. M., Raupach B., Hromockyj A. E., Falkow S. Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9833–9838. doi: 10.1073/pnas.93.18.9833. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Moore K. J., Matlashewski G. Intracellular infection by Leishmania donovani inhibits macrophage apoptosis. J Immunol. 1994 Mar 15;152(6):2930–2937. [PubMed] [Google Scholar]
  28. Pantaleo G., Fauci A. S. New concepts in the immunopathogenesis of HIV infection. Annu Rev Immunol. 1995;13:487–512. doi: 10.1146/annurev.iy.13.040195.002415. [DOI] [PubMed] [Google Scholar]
  29. Pier G. B., Grout M., Zaidi T. S., Olsen J. C., Johnson L. G., Yankaskas J. R., Goldberg J. B. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science. 1996 Jan 5;271(5245):64–67. doi: 10.1126/science.271.5245.64. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Rathman M., Barker L. P., Falkow S. The unique trafficking pattern of Salmonella typhimurium-containing phagosomes in murine macrophages is independent of the mechanism of bacterial entry. Infect Immun. 1997 Apr;65(4):1475–1485. doi: 10.1128/iai.65.4.1475-1485.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Rogers H. W., Callery M. P., Deck B., Unanue E. R. Listeria monocytogenes induces apoptosis of infected hepatocytes. J Immunol. 1996 Jan 15;156(2):679–684. [PubMed] [Google Scholar]
  32. Sansonetti P. J., Arondel J., Cavaillon J. M., Huerre M. Role of interleukin-1 in the pathogenesis of experimental shigellosis. J Clin Invest. 1995 Aug;96(2):884–892. doi: 10.1172/JCI118135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Savill J., Fadok V., Henson P., Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol Today. 1993 Mar;14(3):131–136. doi: 10.1016/0167-5699(93)90215-7. [DOI] [PubMed] [Google Scholar]
  34. Siebers A., Finlay B. B. Models to study enteropathogenic bacteria: lessons learned from Shigella. Trends Microbiol. 1995 Jun;3(6):207–209. doi: 10.1016/s0966-842x(00)88923-4. [DOI] [PubMed] [Google Scholar]
  35. Spriggs M. K. One step ahead of the game: viral immunomodulatory molecules. Annu Rev Immunol. 1996;14:101–130. doi: 10.1146/annurev.immunol.14.1.101. [DOI] [PubMed] [Google Scholar]
  36. Taichman N. S., Dean R. T., Sanderson C. J. Biochemical and morphological characterization of the killing of human monocytes by a leukotoxin derived from Actinobacillus actinomycetemcomitans. Infect Immun. 1980 Apr;28(1):258–268. doi: 10.1128/iai.28.1.258-268.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Takahashi A., Earnshaw W. C. ICE-related proteases in apoptosis. Curr Opin Genet Dev. 1996 Feb;6(1):50–55. doi: 10.1016/s0959-437x(96)90010-6. [DOI] [PubMed] [Google Scholar]
  38. Whyte M. ICE/CED-3 proteasesin apoptosis. Trends Cell Biol. 1996 Jul;6(7):245–248. doi: 10.1016/0962-8924(96)20025-x. [DOI] [PubMed] [Google Scholar]
  39. Zychlinsky A., Fitting C., Cavaillon J. M., Sansonetti P. J. Interleukin 1 is released by murine macrophages during apoptosis induced by Shigella flexneri. J Clin Invest. 1994 Sep;94(3):1328–1332. doi: 10.1172/JCI117452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Zychlinsky A., Sansonetti P. J. Apoptosis as a proinflammatory event: what can we learn from bacteria-induced cell death? Trends Microbiol. 1997 May;5(5):201–204. doi: 10.1016/S0966-842X(97)01044-5. [DOI] [PubMed] [Google Scholar]
  41. Zychlinsky A., Thirumalai K., Arondel J., Cantey J. R., Aliprantis A. O., Sansonetti P. J. In vivo apoptosis in Shigella flexneri infections. Infect Immun. 1996 Dec;64(12):5357–5365. doi: 10.1128/iai.64.12.5357-5365.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Investigation are provided here courtesy of American Society for Clinical Investigation

RESOURCES