Figure 4. Transannular C–H arylation of alicyclic amines.
a, Scope of the C–H arylation reaction with respect to the amine. b, Application of this reaction to the derivatization of varenicline. c, Application of this reaction to the derivatization of cytisine. Yields are reported for pure isolated products. †, Reaction was conducted under modified conditions. See supplementary information for full details.