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. 1991 Jan 15;88(2):502–506. doi: 10.1073/pnas.88.2.502

Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

E T Baldwin 1, I T Weber 1, R St Charles 1, J C Xuan 1, E Appella 1, M Yamada 1, K Matsushima 1, B F Edwards 1, G M Clore 1, A M Gronenborn 1, et al.
PMCID: PMC50839  PMID: 1988949

Abstract

The crystal structure of a host defense system chemotactic factor, interleukin 8, has been solved by molecular replacement using as a model the solution structure derived from nuclear magnetic resonance experiments. The structure was refined with 2 A x-ray data to an R factor of 0.187 (0.217 at 1.6 A). A comparison indicates some potential differences between the structure in solution and in the crystalline state. Our analysis also predicts that residues 4 through 9 on the amino terminus and the beta-bend, which includes His-33, may be important for receptor binding.

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Selected References

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