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Excess folic acid intake impairs glucose tolerance on a high fat diet. (A) Fasting plasma glucose; (B) fasting plasma insulin; (C) blood glucose concentrations at different time points (15, 30, 60, 90, 120 min) after an intraperitoneal (IP) glucose injection; and (D) area under the glucose curve, for male rats fed 60% HF diet with excess or adequate folic acid. Values are means ± SEM, * p < 0.05.
