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. 2008 Jan;5(1):26–36. doi: 10.1016/j.nurt.2007.10.072

The treatment of movement disorders by deep brain stimulation

Hong Yu 1, Joseph S Neimat 1,✉
PMCID: PMC5084124  PMID: 18164481

Summary

It has been understood, for some time, that modulation of deep brain nuclei within the basal ganglia and thalamus can have a therapeutic effect in patients with movement disorders. Because of its reversibility and adjustability, deep brain stimulation (DBS) has largely come to replace traditional ablation procedures. The clinical effects of DBS vary, depending both on the target being stimulated and on the parameters of stimulation. Both aspects are currently the subject of substantial research and discovery. The most common targets for DBS treatment include the subthalamic nucleus for the treatment of advanced Parkinson’s disease, the ventral intermediate nucleus of the thalamus for the treatment of medically refractory essential tremor, and the globus pallidus interna for the treatment of both cervical and generalized dystonias and Parkinson’s disease. We review the current indications, targets, outcomes, and general procedure of DBS for essential tremor, Parkinson’s disease, and dystonia.

Key Words: Movement disorders, Parkinson’s disease, essential tremor, dystonia, deep brain stimulation, DBS

References

  • 1.Hassler R, Riechert T, Mundinger F, Umbach W, Ganglberger JA. Physiological observations in stereotaxic operations in extrapyramidal motor disturbances. Brain. 1960;83:337–350. doi: 10.1093/brain/83.2.337. [DOI] [PubMed] [Google Scholar]
  • 2.Ohye C, Kubota K, Hongo T, Nagao T, Narabayashi H. Ventrolateral and subventrolateral thalamic stimulation: motor effects. Arch Neurol. 1964;11:427–434. doi: 10.1001/archneur.1964.00460220089012. [DOI] [PubMed] [Google Scholar]
  • 3.Lyons KE, Pahwa R, Cornelia CL, et al. Benefits and risks of pharmacological treatments for essential tremor. Drug Saf. 2003;26:461–481. doi: 10.2165/00002018-200326070-00003. [DOI] [PubMed] [Google Scholar]
  • 4.Lyons KE, Pahwa R. Deep brain stimulation and essential tremor. J Clin Neurophysiol. 2004;21:2–5. doi: 10.1097/00004691-200401000-00002. [DOI] [PubMed] [Google Scholar]
  • 5.Hassler R. Anatomy of the thalamus. In: Schaltenbrand G, Bailey P, editors. Introduction to stereotaxis with an atlas of the human brain. 1st ed. Stuttgart: Thieme; 1959. pp. 230–290. [Google Scholar]
  • 6.Starr PA, Vitek JL, Bakay RA. Deep brain stimulation for movement disorders. Neurosurg Clin North Am. 1998;9:381–402. [PubMed] [Google Scholar]
  • 7.Lenz FA, Kwan HC, Martin RL, Tasker RR, Dostrovsky JO, Lenz YE. Single unit analysis of the human ventral thalamic nuclear group: tremor-related activity in functionally identified cells. Brain. 1994;117:531–543. doi: 10.1093/brain/117.3.531. [DOI] [PubMed] [Google Scholar]
  • 8.Lenz FA, Tasker RR, Kwan HC, et al. Single unit analysis of the human ventral thalamic nuclear group: correlation of thalamic “tremor cells” with the 3–6 Hz component of parkinsonian tremor. J Neurosci. 1988;8:754–764. doi: 10.1523/JNEUROSCI.08-03-00754.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 9.Hirai T, Miyazaki M, Nakajima H, Shibazaki T, Ohye C. The correlation between tremor characteristics and the predicted volume of effective lesions in stereotaxic nucleus ventralis intermedius thalamotomy. Brain. 1983;106:1001–1018. doi: 10.1093/brain/106.4.1001. [DOI] [PubMed] [Google Scholar]
  • 10.Hubble JP, Busenbark KL, Wilkinson S, Penn RD, Lyons K, Koller WC. Deep brain stimulation for essential tremor. Neurology. 1996;46:1150–1153. doi: 10.1212/wnl.46.4.1150. [DOI] [PubMed] [Google Scholar]
  • 11.Dostrovsky JO, Lozano AM. Mechanisms of deep brain stimulation. Mov Disord. 2002;17(Suppl 3):S63–S68. doi: 10.1002/mds.10143. [DOI] [PubMed] [Google Scholar]
  • 12.Benabid AL, Pollak P, Gervason C, et al. Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet. 1991;337:403–406. doi: 10.1016/0140-6736(91)91175-T. [DOI] [PubMed] [Google Scholar]
  • 13.Hubble JP, Busenbark KL, Wilkinson S, et al. Effects of thalamic deep brain stimulation based on tremor type and diagnosis. Mov Disord. 1997;12:337–341. doi: 10.1002/mds.870120312. [DOI] [PubMed] [Google Scholar]
  • 14.Ondo W, Jankovic J, Schwartz K, Almaguer M, Simpson RK. Unilateral thalamic deep brain stimulation for refractory essential tremor and Parkinson’s disease tremor. Neurology. 1998;51:1063–1069. doi: 10.1212/wnl.51.4.1063. [DOI] [PubMed] [Google Scholar]
  • 15.Koller WC, Lyons KE, Wilkinson SB, Troster AI, Pahwa R. Long-term safety and efficacy of unilateral deep brain stimulation of the thalamus in essential tremor. Mov Disord. 2001;16:464–468. doi: 10.1002/mds.1089. [DOI] [PubMed] [Google Scholar]
  • 16.Fahn S, Tolosa E, Marin C. Clinical rating scale for tremor. In: Jankovic J, Tolosa E, editors. Parkinson’s disease and movement disorders. 2nd ed. Baltimore: Williams & Wilkins; 1993. pp. 271–280. [Google Scholar]
  • 17.Rehncrona S, Johnels B, Widner H, Törnqvist AL, Hariz M, Sydow O. Long-term efficacy of thalamic deep brain stimulation for tremor: double-blind assessments. Mov Disord. 2003;18:163–170. doi: 10.1002/mds.10309. [DOI] [PubMed] [Google Scholar]
  • 18.Limousin P, Speelman JD, Gielen F, Janssens M. Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. J Neurol Neurosurg Psychiatry. 1999;66:289–296. doi: 10.1136/jnnp.66.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 19.Obwegeser AA, Uitti RJ, Turk MF, Strongosky AJ, Wharen RE. Thalamic stimulation for the treatment of midline tremors in essential tremor patients. Neurology. 2000;54:2342–2344. doi: 10.1212/wnl.54.12.2342. [DOI] [PubMed] [Google Scholar]
  • 20.Ondo W, Almaguer M, Jankovic J, Simpson RK. Thalamic deep brain stimulation: comparison between unilateral and bilateral placement. Arch Neurol. 2001;58:218–222. doi: 10.1001/archneur.58.2.218. [DOI] [PubMed] [Google Scholar]
  • 21.Carpenter MA, Pahwa R, Miyawaki KL, Wilkinson SB, Searl JP, Koller WC. Reduction in voice tremor under thalamic stimulation. Neurology. 1998;50:796–798. doi: 10.1212/wnl.50.3.796. [DOI] [PubMed] [Google Scholar]
  • 22.Sydow O, Thobois S, Alesch F, Speelman JD. Multicentre European study of thalamic stimulation in essential tremor: a six year follow up. J Neurol Neurosurg Psychiatry. 2003;74:1387–1391. doi: 10.1136/jnnp.74.10.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Benabid AL, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg. 1996;84:203–214. doi: 10.3171/jns.1996.84.2.0203. [DOI] [PubMed] [Google Scholar]
  • 24.Siegfried J, Lippitz B. Chronic electrical stimulation of the VL—VPL complex and of the pallidum in the treatment of movement disorders: personal experience since 1982. Stereotact Funct Neurosurg. 1994;62:71–75. doi: 10.1159/000098599. [DOI] [PubMed] [Google Scholar]
  • 25.Vitek JL, Ashe J, DeLong MR, Alexander GE. Physiologic properties and somatotopic organization of the primate motor thalamus. J Neurophysiol. 1994;71:1498–1513. doi: 10.1152/jn.1994.71.4.1498. [DOI] [PubMed] [Google Scholar]
  • 26.Nguyen JP, Degos JD. Thalamic stimulation and proximal tremor: a specific target in the nucleus ventrointermedius thalami. Arch Neurol. 1993;50:498–500. doi: 10.1001/archneur.1993.00540050050014. [DOI] [PubMed] [Google Scholar]
  • 27.Foote KD, Seignourel P, Fernandez HH, et al. Dual electrode thalamic deep brain stimulation for the treatment of posttraumatic and multiple sclerosis tremor. Neurosurgery. 2006;58:ONS-280–285. doi: 10.1227/01.NEU.0000192692.95455.FD. [DOI] [PubMed] [Google Scholar]
  • 28.Tasker RR. Deep brain stimulation is preferable to thalamotomy for tremor suppression. Surg Neurol. 1998;49:145–153. doi: 10.1016/S0090-3019(97)00459-X. [DOI] [PubMed] [Google Scholar]
  • 29.Pahwa R, Lyons KE, Wilkinson SB, et al. Comparison of thalamotomy to deep brain stimulation of the thalamus in essential tremor. Mov Disord. 2001;16:140–143. doi: 10.1002/1531-8257(200101)16:1<140::AID-MDS1025>3.0.CO;2-T. [DOI] [PubMed] [Google Scholar]
  • 30.Schuurman PR, Bosch DA, Bossuyt PM, et al. A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor. N Engl J Med. 2000;342:461–468. doi: 10.1056/NEJM200002173420703. [DOI] [PubMed] [Google Scholar]
  • 31.Koller W, Pahwa R, Busenbark K, et al. High-frequency unilateral thalamic stimulation in the treatment of essential and parkinsonian tremor. Ann Neurol. 1997;42:292–299. doi: 10.1002/ana.410420304. [DOI] [PubMed] [Google Scholar]
  • 32.Pahwa R, Lyons KL, Wilkinson SB, et al. Bilateral thalamic stimulation for the treatment of essential tremor. Neurology. 1999;53:1447–1450. doi: 10.1212/wnl.53.7.1447. [DOI] [PubMed] [Google Scholar]
  • 33.Jankovic J, Cardoso F, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for parkinsonian, essential, and other types of tremor. Neurosurgery. 1995;37:680–686. doi: 10.1227/00006123-199510000-00011. [DOI] [PubMed] [Google Scholar]
  • 34.Twelves D, Perkins KSM, Counsell C. Systematic review of incidence studies of Parkinson’s disease. Mov Disord. 2003;18:19–31. doi: 10.1002/mds.10305. [DOI] [PubMed] [Google Scholar]
  • 35.Schoenberg BS. Descriptive epidemiology of Parkinson’s disease: disease distribution and hypothesis formulation. Adv Neurol. 1987;45:277–283. [PubMed] [Google Scholar]
  • 36.Dorsey ER, Constantinescu R, Thompson JP, et al. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030. Neurology. 2007;68:384–386. doi: 10.1212/01.wnl.0000247740.47667.03. [DOI] [PubMed] [Google Scholar]
  • 37.Schrag A, Quinn N. Dyskinesias and motor fluctuations in Parkinson’s disease: a community-based study. Brain. 2000;123:2297–2305. doi: 10.1093/brain/123.11.2297. [DOI] [PubMed] [Google Scholar]
  • 38.Lang AE, Houeto JL, Krack P, et al. Deep brain stimulation: preoperative issues. Mov Disord. 2006;21(Suppl 14):S171–S196. doi: 10.1002/mds.20955. [DOI] [PubMed] [Google Scholar]
  • 39.Rossi P, Colosimo C, Moro E, Tonali P, Albanese A. Acute challenge with apomorphine and levodopa in parkinsonism. Eur Neurol. 2000;43:95–101. doi: 10.1159/000008142. [DOI] [PubMed] [Google Scholar]
  • 40.Hughes AJ, Lees AJ, Stem GM. Challenge tests to predict the dopaminergic response in untreated Parkinson’s disease. Neurology. 1991;41:1723–1725. doi: 10.1212/wnl.41.11.1723. [DOI] [PubMed] [Google Scholar]
  • 41.Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989;12:366–375. doi: 10.1016/0166-2236(89)90074-X. [DOI] [PubMed] [Google Scholar]
  • 42.DeLong MR. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 1990;13:281–285. doi: 10.1016/0166-2236(90)90110-V. [DOI] [PubMed] [Google Scholar]
  • 43.Mengual E, de las Heras S, Erro E, Lanciego JL, Giménez-Amaya JM. Thalamic interaction between the input and the output systems of the basal ganglia. J Chem Neuroanat. 1999;16:187–200. doi: 10.1016/S0891-0618(99)00010-1. [DOI] [PubMed] [Google Scholar]
  • 44.Hammond C, Rouzaire-Dubois B, Féger J, Jackson A, Crossman AR. Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat. Neuroscience. 1983;9:41–52. doi: 10.1016/0306-4522(83)90045-3. [DOI] [PubMed] [Google Scholar]
  • 45.Kopell BH, Rezai AR, Chang JW, Vitek JL. Anatomy and physiology of the basal ganglia: implications for deep brain stimulation for Parkinson’s disease. Mov Disord. 2006;21(Suppl 14):S238–S246. doi: 10.1002/mds.20958. [DOI] [PubMed] [Google Scholar]
  • 46.Urbain N, Rentéro N, Gervasoni D, Renaud B, Chouvet G. The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat. J Neurosci. 2002;22:8665–8675. doi: 10.1523/JNEUROSCI.22-19-08665.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 47.Wichmann T, Bergman H, DeLong MR. The primate subthalamic nucleus: III, Changes in motor behavior and neuronal activity in the internal pallidum induced by subthalamic inactivation in the MPTP model of parkinsonism. J Neurophysiol. 1994;72:521–530. doi: 10.1152/jn.1994.72.2.521. [DOI] [PubMed] [Google Scholar]
  • 48.Vitek JL. Mechanisms of deep brain stimulation: excitation or inhibition. Mov Disord. 2002;17(Suppl 3):S69–S72. doi: 10.1002/mds.10144. [DOI] [PubMed] [Google Scholar]
  • 49.Aziz TZ, Peggs D, Sambrook MA, Crossman AR. Lesion of the subthalamic nucleus for the alleviation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism in the primate. Mov Disord. 1991;6:288–292. doi: 10.1002/mds.870060404. [DOI] [PubMed] [Google Scholar]
  • 50.Guridi J, Herrero MT, Luquin MR, et al. Subthalamotomy in parkinsonian monkeys: behavioural and biochemical analysis. Brain. 1996;119:1717–1727. doi: 10.1093/brain/119.5.1717. [DOI] [PubMed] [Google Scholar]
  • 51.Vidakovic A, Dragasevic N, Kostic VS. Hemiballism: report of 25 cases. J Neurol Neurosurg Psychiatry. 1994;57:945–949. doi: 10.1136/jnnp.57.8.945. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 52.Pollak P, Benabid AL, Gross C, et al. Effects of the stimulation of the subthalamic nucleus in Parkinson disease [In French] Rev Neurol (Paris) 1993;149:175–176. [PubMed] [Google Scholar]
  • 53.Kleiner-Fisman G, Herzog J, Fisman DN, et al. Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes. Mov Disord. 2006;21(Suppl 14):S290–S304. doi: 10.1002/mds.20962. [DOI] [PubMed] [Google Scholar]
  • 54.Hamani C, Richter E, Schwalb JM, Lozan AM. Bilateral subthalamic nucleus stimulation for Parkinson’s disease: a systematic review of the clinical literature. Neurosurgery. 2005;56:1313–1321. doi: 10.1227/01.NEU.0000159714.28232.C4. [DOI] [PubMed] [Google Scholar]
  • 55.Krack P, Batir A, Van Blercom N, et al. Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N Engl J Med. 2003;349:1925–1934. doi: 10.1056/NEJMoa035275. [DOI] [PubMed] [Google Scholar]
  • 56.Schüpbach WMM, Chastan N, Welter ML, et al. Stimulation of the subthalamic nucleus in Parkinson’s disease: a 5 year follow up. J Neurol Neurosurg Psychiatry. 2005;76:1640–1644. doi: 10.1136/jnnp.2005.063206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 57.Deuschl G, Schade-Brittinger C, Krack P, et al. A randomized trial of deep-brain stimulation for Parkinson’s disease [Erratum in: N Engl J Med 2006;355:1289] N Engl J Med. 2006;355:896–908. doi: 10.1056/NEJMoa060281. [DOI] [PubMed] [Google Scholar]
  • 58.Schüpbach WMM, Maltête D, Houeto JL, et al. Neurosurgery at an earlier stage of Parkinson disease: a randomized, controlled trial. Neurology. 2007;68:267–271. doi: 10.1212/01.wnl.0000250253.03919.fb. [DOI] [PubMed] [Google Scholar]
  • 59.Derost PP, Ouchchane L, Morand D, et al. Is DBS-STN appropriate to treat severe Parkinson disease in an elderly population? Neurology. 2007;68:1345–1355. doi: 10.1212/01.wnl.0000260059.77107.c2. [DOI] [PubMed] [Google Scholar]
  • 60.Limousin P, Pollak P, Hoffmann D, Benazzouz A, Perret JE, Benabid AL. Abnormal involuntary movements induced by subthalamic nucleus stimulation in parkinsonian patients. Mov Disord. 1996;11:231–235. doi: 10.1002/mds.870110303. [DOI] [PubMed] [Google Scholar]
  • 61.Santens P, De Letter M, Van Borsel J, De Reuck J, Caemaert J. Lateralized effects of subthalamic nucleus stimulation on different aspects of speech in Parkinson’s disease. Brain Lang. 2003;87:253–258. doi: 10.1016/S0093-934X(03)00142-1. [DOI] [PubMed] [Google Scholar]
  • 62.Temel Y, Kessels A, Tan S, Topdag A, Boon P, Visser-Vandewalle V. Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review. Parkinsonism Relat Disord. 2006;12:265–272. doi: 10.1016/j.parkreldis.2006.01.004. [DOI] [PubMed] [Google Scholar]
  • 63.Bemey A, Vingerhoets F, Perrin A, et al. Effect on mood of subthalamic DBS for Parkinson’s disease: a consecutive series of 24 patients. Neurology. 2002;59:1427–1429. doi: 10.1212/01.wnl.0000032756.14298.18. [DOI] [PubMed] [Google Scholar]
  • 64.Piasecki SD, Jefferson JW. Psychiatric complications of deep brain stimulation for Parkinson’s disease. J Clin Psychiatry. 2004;65:845–849. doi: 10.4088/JCP.v65n0617. [DOI] [PubMed] [Google Scholar]
  • 65.Burkhard PR, Vingerhoets FJ, Bemey A, Bogousslavsky J, Villemure JG, Ghika J. Suicide after successful deep brain stimulation for movement disorders. Neurology. 2004;63:2170–2172. doi: 10.1212/01.wnl.0000145603.48221.b5. [DOI] [PubMed] [Google Scholar]
  • 66.Hutchison WD, Lozano AM, Tasker RR, Lang AE, Dostrovsky JO. Identification and characterization of neurons with tremor-frequency activity in human globus pallidus. Exp Brain Res. 1997;113:557–563. doi: 10.1007/PL00005606. [DOI] [PubMed] [Google Scholar]
  • 67.Davis KD, Taub E, Houle S, et al. Globus pallidus stimulation activates the cortical motor system during alleviation of parkinsonian symptoms. Nat Med. 1997;3:671–674. doi: 10.1038/nm0697-671. [DOI] [PubMed] [Google Scholar]
  • 68.Baron MS, Vitek JL, Bakay RA, et al. Treatment of advanced Parkinson’s disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol. 1996;40:355–366. doi: 10.1002/ana.410400305. [DOI] [PubMed] [Google Scholar]
  • 69.Lang AE, Lozano AM, Montgomery E, Duff J, Tasker R, Hutchinson W. Posteroventral medial pallidotomy in advanced Parkinson’s disease. N Engl J Med. 1997;337:1036–1042. doi: 10.1056/NEJM199710093371503. [DOI] [PubMed] [Google Scholar]
  • 70.Laitinen LV, Bergenheim AT, Hariz MI. Ventroposterolateral pallidotomy can abolish all parkinsonian symptoms. Stereotact Funct Neurosurg. 1992;58:14–21. doi: 10.1159/000098965. [DOI] [PubMed] [Google Scholar]
  • 71.Gross C, Rougier A, Guehl D, Boraud T, Julien J, Bioulac B. High-frequency stimulation of the globus pallidus intemalis in Parkinson’s disease: a study of seven cases. J Neurosurg. 1997;87:491–498. doi: 10.3171/jns.1997.87.4.0491. [DOI] [PubMed] [Google Scholar]
  • 72.Pahwa R, Wilkinson S, Smith D, Lyons K, Miyawaki E, Koller WC. High-frequency stimulation of the globus pallidus for the treatment of Parkinson’s disease. Neurology. 1997;49:249–253. doi: 10.1212/wnl.49.1.249. [DOI] [PubMed] [Google Scholar]
  • 73.Kumar R, Lang AE, Rodriguez-Oroz MC, et al. Deep brain stimulation of the globus pallidus pars intema in advanced Parkinson’s disease. Neurology. 2000;55:S34–S39. [PubMed] [Google Scholar]
  • 74.Volkmann J, Allert N, Voges J, Sturm V, Schnitzler A, Freund HJ. Long-term results of bilateral pallidal stimulation in Parkinson’s disease. Ann Neurol. 2004;55:871–875. doi: 10.1002/ana.20091. [DOI] [PubMed] [Google Scholar]
  • 75.Visser-Vandewalle V, van der Linden C, Temel Y, Nieman F, Celik H, Beuls E. Long-term motor effect of unilateral pallidal stimulation in 26 patients with advanced Parkinson disease. J Neurosurg. 2003;99:701–707. doi: 10.3171/jns.2003.99.4.0701. [DOI] [PubMed] [Google Scholar]
  • 76.Vingerhoets G, van der Linden C, Lannoo E, et al. Cognitive outcome after unilateral pallidal stimulation in Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;66:297–304. doi: 10.1136/jnnp.66.3.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 77.Volkmann J, Allert N, Voges J, Weiss PH, Freund HJ, Sturm V. Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD. Neurology. 2001;56:548–551. doi: 10.1212/wnl.56.4.548. [DOI] [PubMed] [Google Scholar]
  • 78.Burchiel KJ, Anderson VC, Favre J, Hammerstad JP. Comparison of pallidal and subthalamic nucleus deep brain stimulation for advanced Parkinson’s disease: results of a randomized, blinded pilot study. Neurosurgery. 1999;45:1375–1382. doi: 10.1097/00006123-199912000-00024. [DOI] [PubMed] [Google Scholar]
  • 79.Peppe A, Pierantozzi M, Bassi A, et al. Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease. J Neurosurg. 2004;101:195–200. doi: 10.3171/jns.2004.101.2.0195. [DOI] [PubMed] [Google Scholar]
  • 80.Rodriguez-Oroz MC, Obeso JA, Lang AE, et al. Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain. 2005;128:2240–2249. doi: 10.1093/brain/awh571. [DOI] [PubMed] [Google Scholar]
  • 81.Anderson VC, Burchiel KJ, Hogarth P, Favre J, Hammerstad JP. Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease. Arch Neurol. 2005;62:554–560. doi: 10.1001/archneur.62.4.554. [DOI] [PubMed] [Google Scholar]
  • 82.Fahn S, Bressman SB, Marsden CD. Classification of dystonia. Adv Neurol. 1998;78:1–10. [PubMed] [Google Scholar]
  • 83.Krauss JK, Pohle T, Weber S, Ozdoba C, Burgunder JM. Bilateral stimulation of globus pallidus internus for treatment of cervical dystonia. Lancet. 1999;354:837–838. doi: 10.1016/S0140-6736(99)80022-1. [DOI] [PubMed] [Google Scholar]
  • 84.Ozelius LJ, Hewett J, Kramer P, et al. Fine localization of the torsion dystonia gene (DYT1) on human chromosome 9q34: YAC map and linkage disequilibrium. Genome Res. 1997;7:483–494. doi: 10.1101/gr.7.5.483. [DOI] [PubMed] [Google Scholar]
  • 85.Ozelius LJ, Hewett JW, Page CE, et al. The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein. Nat Genet. 1997;17:40–48. doi: 10.1038/ng0997-40. [DOI] [PubMed] [Google Scholar]
  • 86.Bressman SB, de Leon D, Raymond D, et al. Clinical-genetic spectrum of primary dystonia. Adv Neurol. 1998;78:79–91. [PubMed] [Google Scholar]
  • 87.Han F, Racacho L, Lang AE, Bulman DE, Grimes DA. Refinement of the DYT15 locus in myoclonus dystonia. Mov Disord. 2007;22:888–892. doi: 10.1002/mds.21400. [DOI] [PubMed] [Google Scholar]
  • 88.Grotzsch H, Pizzolato GP, Ghika J, et al. Neuropathology of a case of dopa-responsive dystonia associated with a new genetic locus, DYT14. Neurology. 2002;58:1839–1842. doi: 10.1212/wnl.58.12.1839. [DOI] [PubMed] [Google Scholar]
  • 89.Valente EM, Bentivoglio AR, Cassetta E, et al. DYT13, a novel primary torsion dystonia locus, maps to chromosome 1p36.13-36.32 in an Italian family with cranial-cervical or upper limb onset. Ann Neurol. 2001;49:362–366. doi: 10.1002/ana.73. [DOI] [PubMed] [Google Scholar]
  • 90.Fahn S. Drug treatment of hyperkinetic movement disorders. Semin Neurol. 1987;7:192–208. doi: 10.1055/s-2008-1041419. [DOI] [PubMed] [Google Scholar]
  • 91.Jankovic J, Schwartz K. Response and immunoresistance to botulinum toxin injections. Neurology. 1995;45:1743–1746. doi: 10.1212/wnl.45.9.1743. [DOI] [PubMed] [Google Scholar]
  • 92.Brin MF, Jankovic J, Cornelia C, et al. Treatment of cervical dystonia using botulinum toxin. In: Kurlan R, et al., editors. Treatment of movement disorders. Philadelphia: Lippincott Williams & Wilkins; 1995. pp. 183–246. [Google Scholar]
  • 93.Lew MF, Brashear A, Factor S. The safety and efficacy of botulinum toxin type B in the treatment of patients with cervical dystonia: summary of three controlled clinical trials. Neurology. 2000;55:S29–S35. [PubMed] [Google Scholar]
  • 94.Ondo WG, Krauss JK. Surgical therapies for dystonia. In: Brin MF, Cornelia C, Jankovic J, editors. Dystonia: etiology, clinical features, and treatment. Philadelphia: Lippincott Williams & Wilkins; 2003. pp. 125–147. [Google Scholar]
  • 95.Cooper IS. 20-year followup study of the neurosurgical treatment of dystonia musculorum deformans. Adv Neurol. 1976;14:423–452. [PubMed] [Google Scholar]
  • 96.Andrew J, Fowler CJ, Harrison MJ. Stereotaxic thalamotomy in 55 cases of dystonia. Brain. 1983;106:981–1000. doi: 10.1093/brain/106.4.981. [DOI] [PubMed] [Google Scholar]
  • 97.Cardoso F, Jankovic J, Grossman RG, Hamilton WJ. Outcome after stereotactic thalamotomy for dystonia and hemiballismus. Neurosurgery. 1995;36:501–507. doi: 10.1227/00006123-199503000-00009. [DOI] [PubMed] [Google Scholar]
  • 98.Tasker RR, Doorly T, Yamashiro K. Thalamotomy in generalized dystonia. Adv Neurol. 1988;50:615–631. [PubMed] [Google Scholar]
  • 99.Iacono RP, Kuniyoshi SM, Lonser RR, Maeda G, Inae AM, Ashwal S. Simultaneous bilateral pallidoansotomy for idiopathic dystonia musculorum deformans. Pediatr Neurol. 1996;14:145–148. doi: 10.1016/0887-8994(96)00003-3. [DOI] [PubMed] [Google Scholar]
  • 100.Vitek JL, Zhang J, Evatt M, et al. GPi pallidotomy for dystonia: clinical outcome and neuronal activity. Adv Neurol. 1998;78:211–219. [PubMed] [Google Scholar]
  • 101.Lozano AM, Kumar R, Gross RE, et al. Globus pallidus internus pallidotomy for generalized dystonia. Mov Disord. 1997;12:865–870. doi: 10.1002/mds.870120606. [DOI] [PubMed] [Google Scholar]
  • 102.Silberstein P, Kuhn AA, Kupsch A, et al. Patterning of globus pallidus local field potentials differs between Parkinson’s disease and dystonia. Brain. 2003;126:2597–2608. doi: 10.1093/brain/awg267. [DOI] [PubMed] [Google Scholar]
  • 103.Vitek JL, Chockkan V, Zhang JY, et al. Neuronal activity in the basal ganglia in patients with generalized dystonia and hemiballismus. Ann Neurol. 1999;46:22–35. doi: 10.1002/1531-8249(199907)46:1<22::AID-ANA6>3.0.CO;2-Z. [DOI] [PubMed] [Google Scholar]
  • 104.Hutchison WD, Lang AE, Dostrovsky JO, Lozano AM. Pallidal neuronal activity: implications for models of dystonia. Ann Neurol. 2003;53:480–488. doi: 10.1002/ana.10474. [DOI] [PubMed] [Google Scholar]
  • 105.Lenz FA, Suarez JI, Metman LV, et al. Pallidal activity during dystonia: somatosensory reorganisation and changes with severity. J Neurol Neurosurg Psychiatry. 1998;65:767–770. doi: 10.1136/jnnp.65.5.767. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 106.Kuhn AA, Meyer BU, Trottenberg T, Brandt SA, Schneider GH, Kupsch A. Modulation of motor cortex excitability by pallidal stimulation in patients with severe dystonia. Neurology. 2003;60:768–774. doi: 10.1212/01.wnl.0000044396.64752.4c. [DOI] [PubMed] [Google Scholar]
  • 107.Magyar-Lehmann S, Antonini A, Roelcke U, et al. Cerebral glucose metabolism in patients with spasmodic torticollis. Mov Disord. 1997;12:704–708. doi: 10.1002/mds.870120513. [DOI] [PubMed] [Google Scholar]
  • 108.Kupsch A, Kuehn A, Klaffke S, et al. Deep brain stimulation in dystonia. J Neurol. 2003;250(Suppl 1):I47–I52. doi: 10.1007/s00415-003-1110-2. [DOI] [PubMed] [Google Scholar]
  • 109.Yianni J, Bain PG, Gregory RP, et al. Post-operative progress of dystonia patients following globus pallidus internus deep brain stimulation. Eur J Neurol. 2003;10:239–247. doi: 10.1046/j.1468-1331.2003.00592.x. [DOI] [PubMed] [Google Scholar]
  • 110.Coubes P, Roubertic A, Vayssiere N, Hemm S, Echenne B. Treatment of DYT1-generalised dystonia by stimulation of the internal globus pallidus. Lancet. 2000;355:2220–2221. doi: 10.1016/S0140-6736(00)02410-7. [DOI] [PubMed] [Google Scholar]
  • 111.Cif L, El Fertit H, Vayssiere N, et al. Treatment of dystonic syndromes by chronic electrical stimulation of the internal globus pallidus. J Neurosurg Sci. 2003;47:52–55. [PubMed] [Google Scholar]
  • 112.Vidailhet M, Vercueil L, Houeto JL, et al. Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia. N Engl J Med. 2005;352:459–467. doi: 10.1056/NEJMoa042187. [DOI] [PubMed] [Google Scholar]
  • 113.Kupsch A, Benecke R, Muller J, et al. Pallidal deep-brain stimulation in primary generalized or segmental dystonia. N Engl J Med. 2006;355:1978–1990. doi: 10.1056/NEJMoa063618. [DOI] [PubMed] [Google Scholar]
  • 114.Capelle HH, Weigel R, Krauss JK. Bilateral pallidal stimulation for blepharospasm-oromandibular dystonia (Meige syndrome) Neurology. 2003;60:2017–2018. doi: 10.1212/01.wnl.0000068527.25191.78. [DOI] [PubMed] [Google Scholar]
  • 115.Muta D, Goto S, Nishikawa S, et al. Bilateral pallidal stimulation for idiopathic segmental axial dystonia advanced from Meige syndrome refractory to bilateral thalamotomy. Mov Disord. 2001;16:774–777. doi: 10.1002/mds.1122. [DOI] [PubMed] [Google Scholar]
  • 116.Holloway KL, Baron MS, Brown R, Cifu DX, Carne W, Ramakrishnan V. Deep brain stimulation for dystonia: a meta-analysis. Neuromodulation. 2006;9:253–261. doi: 10.1111/j.1525-1403.2006.00067.x. [DOI] [PubMed] [Google Scholar]
  • 117.Kupsch A, Klaffke S, Kühn AA, et al. The effects of frequency in pallidal deep brain stimulation for primary dystonia [Erratum in: J Neurol 2004;251:1031] J Neurol. 2003;250:1201–1205. doi: 10.1007/s00415-003-0179-0. [DOI] [PubMed] [Google Scholar]
  • 118.Alterman RL, Shils JL, Miravite J, Tagliati M. Lower stimulation frequency can enhance tolerability and efficacy of pallidal deep brain stimulation for dystonia. Mov Disord. 2007;22:366–368. doi: 10.1002/mds.21274. [DOI] [PubMed] [Google Scholar]
  • 119.Kelly PJ, Derome P, Guiot G. Thalamic spatial variability and the surgical results of lesions placed with neurophysiologic control. Surg Neurol. 1978;9:307–315. [PubMed] [Google Scholar]
  • 120.Andrade-Souza YM, Schwalb JM, Hamani C, et al. Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson’s disease. Neurosurgery. 2005;56:360–368. doi: 10.1227/01.NEU.0000156547.24603.EE. [DOI] [PubMed] [Google Scholar]
  • 121.Nowinski WL, Belov D, Pollak P, Benabid AL. Statistical analysis of 168 bilateral subthalamic nucleus implantations by means of the probabilistic functional atlas. Neurosurgery. 2005;57:319–330. doi: 10.1227/01.NEU.0000180960.75347.11. [DOI] [PubMed] [Google Scholar]
  • 122.D’Haese PF, Pallavaram S, Niermann K, et al. Automatic selection of DBS target points using multiple electrophysiological atlases. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2005;8:427–434. doi: 10.1007/11566489_53. [DOI] [PubMed] [Google Scholar]
  • 123.Umemura A, Jaggi JL, Hurtig HI, et al. Deep brain stimulation for movement disorders: morbidity and mortality in 109 patients. J Neurosurg. 2003;98:779–784. doi: 10.3171/jns.2003.98.4.0779. [DOI] [PubMed] [Google Scholar]
  • 124.Henderson JM. Frameless localization for functional neurosurgical procedures: a preliminary accuracy study. Stereotact Funct Neurosurg. 2004;82:135–141. doi: 10.1159/000081345. [DOI] [PubMed] [Google Scholar]
  • 125.Fitzpatrick JM, Konrad PE, Nickele C, Cetinkaya E, Kao C. Accuracy of customized miniature stereotactic platforms. Stereotact Funct Neurosurg. 2005;83:25–31. doi: 10.1159/000085023. [DOI] [PubMed] [Google Scholar]
  • 126.Lenz FA, Dostrovsky JO, Kwan HC, Tasker RR, Yamashiro K, Murphy JT. Methods for microstimulation and recording of single neurons and evoked potentials in the human central nervous system. J Neurosurg. 1988;68:630–634. doi: 10.3171/jns.1988.68.4.0630. [DOI] [PubMed] [Google Scholar]
  • 127.Hariz MI, Fodstad H. Do microelectrode techniques increase accuracy or decrease risks in pallidotomy and deep brain stimulation? A critical review of the literature. Stereotact Funct Neurosurg. 1999;72:157–169. doi: 10.1159/000029720. [DOI] [PubMed] [Google Scholar]
  • 128.Binder DK, Rau GM, Starr PA. Risk factors for hemorrhage during microelectrode-guided deep brain stimulator implantation for movement disorders. Neurosurgery. 2005;56:722–732. doi: 10.1227/01.NEU.0000156473.57196.7E. [DOI] [PubMed] [Google Scholar]
  • 129.Yamamoto M, Jimbo M, Ide M, Tanaka N, Umebara Y, Hagiwara S. Postoperative neurosurgical infection and antibiotic prophylaxis. Neurol Med Chir (Tokyo) 1992;32:72–79. doi: 10.2176/nmc.32.72. [DOI] [PubMed] [Google Scholar]

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