Behavioral models of pain states evoked by physical injury to the peripheral nerve

Linda S Sorkin; Tony L Yaksh

doi:10.1016/j.nurt.2009.07.007

. 2009 Oct;6(4):609–619. doi: 10.1016/j.nurt.2009.07.007

Behavioral models of pain states evoked by physical injury to the peripheral nerve

Linda S Sorkin ^1,^✉, Tony L Yaksh ^1,^✉

PMCID: PMC5084283 PMID: 19789066

Summary

Physical injury or compression of the root, dorsal root ganglion, or peripheral sensory axon leads to well-defined changes in biology and function. Behaviorally, humans report ongoing painful dysesthesias and aberrations in function, such that an otherwise innocuous stimulus will yield a pain report. These behavioral reports are believed to reflect the underlying changes in nerve function after injury, wherein increased spontaneous activity arises from the neuroma and dorsal root ganglion and spinal changes increase the response of spinal projection neurons. These pain states are distinct from those associated with tissue injury and pose particular problems in management. To provide for developing an understanding of the underlying mechanisms of these pain states and to promote development of therapeutic agents, preclinical models involving section, compression, and constriction of the peripheral nerve or compression of the dorsal root ganglion have been developed. These models give rise to behaviors, which parallel those observed in the human after nerve injury. The present review considers these models and their application.

Key Words: Tactile allodynia, spontaneous pain, dorsal root ganglion, nerve compression, autotomy

Contributor Information

Linda S. Sorkin, Email: lsorkin@ucsd.edu

Tony L. Yaksh, Email: tyaksh@ucsd.edu

References

1.Sunderland S. Nerves and nerve injuries. Edinburgh London: Churchill Livingstone; 1972. [Google Scholar]
2.Weir-Mitchell S, Moorhouse GR, Keen WW. Gunshot wounds and other injuries of nerves. Philadephia: Lippincott; 1864. [Google Scholar]
3.Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006;52:77–92. doi: 10.1016/j.neuron.2006.09.021. [DOI] [PMC free article] [PubMed] [Google Scholar]
4.Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol. 2001;429:23–37. doi: 10.1016/s0014-2999(01)01303-6. [DOI] [PubMed] [Google Scholar]
5.Schoffnegger D, Ruscheweyh R, Sandkuhler J. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain. 2008;135:300–310. doi: 10.1016/j.pain.2007.12.016. [DOI] [PubMed] [Google Scholar]
6.Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther. 2003;25:81–104. doi: 10.1016/s0149-2918(03)90011-7. [DOI] [PubMed] [Google Scholar]
7.Gold MS. Sodium channels and pain therapy. Curr Opin Anaesthesiol. 2000;13:565–572. doi: 10.1097/00001503-200010000-00014. [DOI] [PubMed] [Google Scholar]
8.Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev 2007:CD005454. [DOI] [PMC free article] [PubMed]
9.Eisenberg E, McNicol ED, Carr DB. Efficacy of mu-opioid agonists in the treatment of evoked neuropathic pain: systematic review of randomized controlled trials. Eur J Pain. 2006;10:667–676. doi: 10.1016/j.ejpain.2005.10.007. [DOI] [PubMed] [Google Scholar]
10.Nicholson B. Benefits of extended-release opioid analgesic formulations in the treatment of chronic pain. Pain Pract. 2009;9:71–81. doi: 10.1111/j.1533-2500.2008.00232.x. [DOI] [PubMed] [Google Scholar]
11.Raber P, Devor M. Social variables affect phenotype in the neuroma model of neuropathic pain. Pain. 2002;97:139–150. doi: 10.1016/s0304-3959(02)00013-1. [DOI] [PubMed] [Google Scholar]
12.Chesler EJ, Wilson SG, Lariviere WR, Rodriguez-Zas SL, Mogil JS. Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive. Neurosci Biobehav Rev. 2002;26:907–923. doi: 10.1016/s0149-7634(02)00103-3. [DOI] [PubMed] [Google Scholar]
13.Vissers K, De Jongh R, Hoffmann V, Heylen R, Crul B, Meert T. Internal and external factors affecting the development of neuropathic pain in rodents. Is it all about pain? Pain Pract. 2003;3:326–342. doi: 10.1111/j.1530-7085.2003.03037.x. [DOI] [PubMed] [Google Scholar]
14.Wall PD, Devor M, Inbal R, et al. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain. 1979;7:103–111. doi: 10.1016/0304-3959(79)90002-2. [DOI] [PubMed] [Google Scholar]
15.Attal N, Filliatreau G, Perrot S, Jazat F, Di Giamberardino L, Guilbaud G. Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve. Pain. 1994;59:301–312. doi: 10.1016/0304-3959(94)90083-3. [DOI] [PubMed] [Google Scholar]
16.DeLeo JA, Coombs DW, Willenbring S, et al. Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat. Pain. 1994;56:9–16. doi: 10.1016/0304-3959(94)90145-7. [DOI] [PubMed] [Google Scholar]
17.Levitt M. Dysesthesias and self-mutilation in humans and subhumans: a review of clinical and experimental studies. Brain Res. 1985;357:247–290. doi: 10.1016/0165-0173(85)90027-x. [DOI] [PubMed] [Google Scholar]
18.Walczak JS, Pichette V, Leblond F, Desbiens K, Beaulieu P. Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. Neuroscience. 2005;132:1093–1102. doi: 10.1016/j.neuroscience.2005.02.010. [DOI] [PubMed] [Google Scholar]
19.Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 2000;87:149–158. doi: 10.1016/S0304-3959(00)00276-1. [DOI] [PubMed] [Google Scholar]
20.Hofmann HA, De Vry J, Siegling A, Spreyer P, Denzer D. Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain. Eur J Pharmacol. 2003;470:17–25. doi: 10.1016/s0014-2999(03)01753-9. [DOI] [PubMed] [Google Scholar]
21.Coderre TJ, Grimes RW, Melzack R. Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain. Pain. 1986;26:61–84. doi: 10.1016/0304-3959(86)90174-0. [DOI] [PubMed] [Google Scholar]
22.Blumenkopf B, Lipman JJ. Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain. Pain. 1991;45:203–209. doi: 10.1016/0304-3959(91)90189-5. [DOI] [PubMed] [Google Scholar]
23.Wagner R, DeLeo JA, Coombs DW, Myers RR. Gender differences in autotomy following sciatic cryoneurolysis in the rat. Physiol Behav. 1995;58:37–41. doi: 10.1016/0031-9384(95)00037-j. [DOI] [PubMed] [Google Scholar]
24.Inbal R, Devor M, Tuchendler O, Lieblich I. Autotomy following nerve injury: genetic factors in the development of chronic pain. Pain. 1980;9:327–337. doi: 10.1016/0304-3959(80)90047-0. [DOI] [PubMed] [Google Scholar]
25.Devor M, Raber P. Heritability of symptoms in an experimental model of neuropathic pain. Pain. 1990;42:51–67. doi: 10.1016/0304-3959(90)91092-W. [DOI] [PubMed] [Google Scholar]
26.Zeltser R, Beilin B, Zaslansky R, Seltzer Z. Comparison of autotomy behavior induced in rats by various clinically-used neurectomy methods. Pain. 2000;89:19–24. doi: 10.1016/S0304-3959(00)00342-0. [DOI] [PubMed] [Google Scholar]
27.Dowdall T, Robinson I, Meert TF. Comparison of five different rat models of peripheral nerve injury. Pharmacol Biochem Behav. 2005;80:93–108. doi: 10.1016/j.pbb.2004.10.016. [DOI] [PubMed] [Google Scholar]
28.Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man [see comments] Pain. 1988;33:87–107. doi: 10.1016/0304-3959(88)90209-6. [DOI] [PubMed] [Google Scholar]
29.Maves TJ, Pechman PS, Gebhart GF, Meller ST. Possible chemical contribution from chronic-gut sutures produces disorders of pain sensation like those seen in man. Pain. 1993;54:57–69. doi: 10.1016/0304-3959(93)90100-4. [DOI] [PubMed] [Google Scholar]
30.Carlton SM, Dougherty PM, Pover CM, Coggeshall RE. Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. Neurosci Lett. 1991;131:88–92. doi: 10.1016/0304-3940(91)90343-r. [DOI] [PubMed] [Google Scholar]
31.Kajander KC, Bennett GJ. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J Neurophysiol. 1992;68:734–744. doi: 10.1152/jn.1992.68.3.734. [DOI] [PubMed] [Google Scholar]
32.Sommer C, Lalonde A, Heckman HM, Rodriguez M, Myers RR. Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J Neuropath Exp Neurol. 1995;54:635–643. doi: 10.1097/00005072-199509000-00004. [DOI] [PubMed] [Google Scholar]
33.Myers RR, Heckman HM, Rodriguez M. Reduced hyperalgesia in nerve-injured WLD mice: Relationship to nerve fiber phagocytosis, axonal degeneration and regeneration in normal mice. Exptl Neurol. 1996;141:94–101. doi: 10.1006/exnr.1996.0142. [DOI] [PubMed] [Google Scholar]
34.Grelik C, Bennett GJ, Ribeiro-da-Silva A. Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury. Eur J Neurosci. 2005;21:2475–2487. doi: 10.1111/j.1460-9568.2005.04089.x. [DOI] [PubMed] [Google Scholar]
35.Vos BP, Benoist JM, Gautron M, Guilbaud G. Changes in neuronal activities in the two ventral posterior medial thalamic nuclei in an experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve. Somatosens Mot Res. 2000;17:109–122. doi: 10.1080/08990220050020535. [DOI] [PubMed] [Google Scholar]
36.Kitagawa J, Takeda M, Suzuki I, et al. Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy. Eur J Neurosci. 2006;24:1976–1986. doi: 10.1111/j.1460-9568.2006.05065.x. [DOI] [PubMed] [Google Scholar]
37.Sommer C, Schmidt C, George A, Toyka KV. A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci Lett. 1997;237:45–48. doi: 10.1016/s0304-3940(97)00813-6. [DOI] [PubMed] [Google Scholar]
38.Carlton SM, Lekan HA, Kim SH, Chung JM. Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate. Pain. 1994;56:155–166. doi: 10.1016/0304-3959(94)90090-6. [DOI] [PubMed] [Google Scholar]
39.Vierck CJ, Acosta-Rua AJ, Johnson RD. Bilateral chronic constriction of the sciatic nerve: a model of long-term cold hyperalgesia. J Pain. 2005;6:507–517. doi: 10.1016/j.jpain.2005.03.003. [DOI] [PubMed] [Google Scholar]
40.Jasmin L, Kohan L, Franssen M, Janni G, Goff JR. The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. Pain. 1998;75:367–382. doi: 10.1016/s0304-3959(98)00017-7. [DOI] [PubMed] [Google Scholar]
41.Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN. Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain. Reg Anesth Pain Med. 2002;27:357–366. doi: 10.1053/rapm.2002.31930. [DOI] [PubMed] [Google Scholar]
42.Vogel C, Mossner R, Gerlach M, et al. Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci. 2003;23:708–715. doi: 10.1523/JNEUROSCI.23-02-00708.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]
43.Hutchinson MR, Zhang Y, Brown K, et al. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4) Eur J Neurosci. 2008;28:20–29. doi: 10.1111/j.1460-9568.2008.06321.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
44.Milligan ED, Sloane EM, Langer SJ, et al. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain. 2005;1:9–9. doi: 10.1186/1744-8069-1-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
45.Kingery WS, Lu JD, Roffers JA, Kell DR. The resolution of neuropathic hyperalgesia following motor and sensory functional recovery in sciatic axonotmetic mononeuropathies. Pain. 1994;58:157–168. doi: 10.1016/0304-3959(94)90196-1. [DOI] [PubMed] [Google Scholar]
46.Bullens P, Daemen M, Freling G, Kitslaar P, Van den Wildenberg F, Kurvers H. Motor dysfunction and reflex sympathetic dystrophy. Bilateral motor denervation in an experimental model. Acta Orthop Belg. 1998;64:218–223. [PubMed] [Google Scholar]
47.Myers RR, Yamamoto T, Yaksh TL, Powell HC. The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia. Anesthesiology. 1993;78:308–316. doi: 10.1097/00000542-199302000-00015. [DOI] [PubMed] [Google Scholar]
48.Jacobs JM, Ro LS. A morphological study of experimental mononeuropathy in the rat: early ischemic changes. J Neurol Sci. 1994;127:143–152. doi: 10.1016/0022-510x(94)90066-3. [DOI] [PubMed] [Google Scholar]
49.Ramer MS, Bisby MA. Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury. Pain. 1997;70:237–244. doi: 10.1016/s0304-3959(97)03331-9. [DOI] [PubMed] [Google Scholar]
50.McLachlan EM, Janig W, Devor M, Michaelis M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature. 1993;363:543–546. doi: 10.1038/363543a0. [DOI] [PubMed] [Google Scholar]
51.Ramer MS, French GD, Bisby MA. Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG. Pain. 1997;72:71–78. doi: 10.1016/s0304-3959(97)00019-5. [DOI] [PubMed] [Google Scholar]
52.Neil A, Attal N, Guilbaud G. Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy. Brain Res. 1991;565:237–246. doi: 10.1016/0006-8993(91)91655-k. [DOI] [PubMed] [Google Scholar]
53.Perrot S, Attal N, Ardid D, Guilbaud G. Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine? Pain. 1993;52:41–47. doi: 10.1016/0304-3959(93)90111-2. [DOI] [PubMed] [Google Scholar]
54.Tall JM, Stuesse SL, Cruce WL, Crisp T. Gender and the behavioral manifestations of neuropathic pain. Pharmacol Biochem Behav. 2001;68:99–104. doi: 10.1016/s0091-3057(00)00461-5. [DOI] [PubMed] [Google Scholar]
55.Stevens CW, Kajander KC, Bennett GJ, Seybold VS. Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain. 1991;46:315–326. doi: 10.1016/0304-3959(91)90114-D. [DOI] [PubMed] [Google Scholar]
56.Backonja MM, Miletic G, Miletic V. The effect of continuous morphine analgesia on chronic thermal hyperalgesia due to sciatic constriction injury in rats. Neurosci Lett. 1995;196:61–64. doi: 10.1016/0304-3940(95)11844-m. [DOI] [PubMed] [Google Scholar]
57.Catheline G, Kayser V, Idanpaan-Heikkila JJ, Guilbaud G. The antinociceptive activity of kappa-but not delta-opioid receptor agonists is maintained in morphine-tolerant neuropathic rats. Eur J Pharmacol. 1996;318:273–281. doi: 10.1016/s0014-2999(96)00790-x. [DOI] [PubMed] [Google Scholar]
58.Catheline G, Kayser V, Guilbaud G. Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors. Eur J Pharmacol. 1996;315:135–143. doi: 10.1016/s0014-2999(96)00629-2. [DOI] [PubMed] [Google Scholar]
59.Catheline G, Le Guen S, Besson JM. Intravenous morphine does not modify dorsal horn touch-evoked allodynia in the mononeuropathic rat: a Fos study. Pain. 2001;92:389–398. doi: 10.1016/S0304-3959(01)00283-4. [DOI] [PubMed] [Google Scholar]
60.Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007;132:289–300. doi: 10.1016/j.pain.2007.03.022. [DOI] [PubMed] [Google Scholar]
61.Leiphart JW, Dills CV, Zikel OM, Kim DL, Levy RM. A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. J Neurosurg. 1995;82:595–599. doi: 10.3171/jns.1995.82.4.0595. [DOI] [PubMed] [Google Scholar]
62.Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors. Anesthesiology. 1991;75:817–826. doi: 10.1097/00000542-199111000-00014. [DOI] [PubMed] [Google Scholar]
63.Dougherty PM, Garrison CJ, Carlton SM. Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. Brain Res. 1992;570:109–115. doi: 10.1016/0006-8993(92)90570-y. [DOI] [PubMed] [Google Scholar]
64.Sotgiu ML, Castagna A, Lacerenza M, Marchettini P. Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy. Pain. 1995;61:3–10. doi: 10.1016/0304-3959(94)00120-4. [DOI] [PubMed] [Google Scholar]
65.Xie W, Strong JA, Meij JT, Zhang JM, Yu L. Neuropathic pain: early spontaneous afferent activity is the trigger. Pain. 2005;116:243–256. doi: 10.1016/j.pain.2005.04.017. [DOI] [PMC free article] [PubMed] [Google Scholar]
66.Sotgiu ML, Biella G, Castagna A, Lacerenza M, Marchettini P. Different time-courses of i.v. lidocaine effect on ganglionic and spinal units in neuropathic rats. Neuroreport. 1994;5:873–876. doi: 10.1097/00001756-199404000-00005. [DOI] [PubMed] [Google Scholar]
67.Omana-Zapata I, Khabbaz MA, Hunter JC, Bley KR. QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Research. 1997;771:228–237. doi: 10.1016/s0006-8993(97)00770-1. [DOI] [PubMed] [Google Scholar]
68.Smith LJ, Shih A, Miletic G, Miletic V. Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain. 2002;97:267–273. doi: 10.1016/S0304-3959(02)00028-3. [DOI] [PubMed] [Google Scholar]
69.Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 1994;80:383–391. [PubMed] [Google Scholar]
70.Datta S, Waghray T, Torres M, Glusman S. Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. Anesth Analg. 2004;98:178–184. doi: 10.1213/01.ANE.0000093223.35824.23. [DOI] [PubMed] [Google Scholar]
71.Cui JC, Linderoth B, Meyerson BA. Incidence of mononeuropathy in rats is influenced by pre-emptive alteration of spinal excitability. Eur J Pain. 1997;1:53–59. doi: 10.1016/s1090-3801(97)90053-7. [DOI] [PubMed] [Google Scholar]
72.Tian J, Gu Y, Su D, Wu Y, Wang X. Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain. 2009;13:130–137. doi: 10.1016/j.ejpain.2008.03.013. [DOI] [PubMed] [Google Scholar]
73.Chen Y, Shu Y, Zhao Z. Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat. Neuroreport. 1999;10:2779–2782. doi: 10.1097/00001756-199909090-00015. [DOI] [PubMed] [Google Scholar]
74.Ma W, Eisenach JC. Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Brain Res. 2003;970:110–118. doi: 10.1016/s0006-8993(03)02293-5. [DOI] [PubMed] [Google Scholar]
75.Leiphart JW, Dills CV, Levy RM. Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. J Neurosurg. 2004;101:641–647. doi: 10.3171/jns.2004.101.4.0641. [DOI] [PubMed] [Google Scholar]
76.Levy R, Leiphart J, Dills C. Analgesic action of acute and chronic intraspinally administered opiate and alpha 2-adrenergic agonists in chronic neuropathic pain. Stereotact Funct Neurosurg. 1994;62:279–289. doi: 10.1159/000098633. [DOI] [PubMed] [Google Scholar]
77.Munglani R, Bond A, Smith GD, et al. Changes in neuronal markers in a mononeuropathic rat model relationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia. Pain. 1995;63:21–31. doi: 10.1016/0304-3959(95)00013-I. [DOI] [PubMed] [Google Scholar]
78.Hord AH, Denson DD, Stowe B, Haygood RM. alpha-1 and alpha-2 adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury. Anesth Analg. 2001;92:1558–1562. doi: 10.1097/00000539-200106000-00042. [DOI] [PubMed] [Google Scholar]
79.Lang E, Hord AH, Denson D. Venlafaxine hydrochloride (Effexor) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. Pain. 1996;68:151–155. doi: 10.1016/S0304-3959(96)03223-X. [DOI] [PubMed] [Google Scholar]
80.Ikeda T, Ishida Y, Naono R, et al. Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain. Neurosci Res. 2009;63:42–46. doi: 10.1016/j.neures.2008.10.002. [DOI] [PubMed] [Google Scholar]
81.Yasuda T, Iwamoto T, Ohara M, et al. The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino) pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. Jpn J Pharmacol. 1999;79:65–73. doi: 10.1254/jjp.79.65. [DOI] [PubMed] [Google Scholar]
82.Nielsen CK, Lewis RJ, Alewood D, et al. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005;118:112–124. doi: 10.1016/j.pain.2005.08.002. [DOI] [PubMed] [Google Scholar]
83.Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990;43:205–218. doi: 10.1016/0304-3959(90)91074-S. [DOI] [PubMed] [Google Scholar]
84.Xu M, Aita M, Chavkin C. Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions. J Pain. 2008;9:1036–1048. doi: 10.1016/j.jpain.2008.06.006. [DOI] [PMC free article] [PubMed] [Google Scholar]
85.Shinoda M, Kawashima K, Ozaki N, Asai H, Nagamine K, Sugiura Y. P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain. J Pain. 2007;8:588–597. doi: 10.1016/j.jpain.2007.03.001. [DOI] [PubMed] [Google Scholar]
86.Matsuzawa-Yanagida K, Narita M, Nakajima M, et al. Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites. Neuropsychopharmacology. 2008;33:1952–1965. doi: 10.1038/sj.npp.1301590. [DOI] [PubMed] [Google Scholar]
87.Sinnott CJ, Garfield JM, Strichartz GR. Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat. Pain. 1999;80:521–531. doi: 10.1016/S0304-3959(98)00245-0. [DOI] [PubMed] [Google Scholar]
88.Seltzer Z, Shir Y. Sympathetically-maintained causalgiform disorders in a model for neuropathic pain: a review. J Basic Clin Physiol Pharmacol. 1991;2:17–61. doi: 10.1515/jbcpp.1991.2.1-2.17. [DOI] [PubMed] [Google Scholar]
89.Shir Y, Seltzer Z. Heat hyperalgesia following partial sciatic ligation in rats: interacting nature and nurture. Neuroreport. 2001;12:809–813. doi: 10.1097/00001756-200103260-00038. [DOI] [PubMed] [Google Scholar]
90.Fecho K, Valtschanoff JG. Acute inflammatory and neuropathic pain in Lewis and Fischer rats. J Neuroendocrinol. 2006;18:504–513. doi: 10.1111/j.1365-2826.2006.01442.x. [DOI] [PubMed] [Google Scholar]
91.Shir Y, Seltzer Z. A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neuroscience Letters. 1990;115:62–67. doi: 10.1016/0304-3940(90)90518-e. [DOI] [PubMed] [Google Scholar]
92.Ma W, Quirion R. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Pain. 2002;99:175–184. doi: 10.1016/s0304-3959(02)00097-0. [DOI] [PubMed] [Google Scholar]
93.Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia. 1998;23:75–83. [PubMed] [Google Scholar]
94.Ma W, Bisby MA. Partial sciatic nerve transection induced tyrosine hydroxidase immunoreactive axon sprouting around both injured and spared dorsal root ganglion neurons which project to the gracile nucleus in middle-aged rats. Neurosci Lett. 1999;275:117–120. doi: 10.1016/s0304-3940(99)00746-6. [DOI] [PubMed] [Google Scholar]
95.Tracey DJ, Cunningham JE, Romm MA. Peripheral hyperalgesia in experimental neuropathy: mediation by alpha 2-adrenoreceptors on post-ganglionic sympathetic terminals. Pain. 1995;60:317–327. doi: 10.1016/0304-3959(94)00141-z. [DOI] [PubMed] [Google Scholar]
96.Ma W, Du W, Eisenach JC. Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. Anesthesiology. 2003;98:203–208. doi: 10.1097/00000542-200301000-00031. [DOI] [PubMed] [Google Scholar]
97.Schechtmann G, Wallin J, Meyerson BA, Linderoth B. Intrathecal clonidine potentiates suppression of tactile hypersensitivity by spinal cord stimulation in a model of neuropathy. Anesth Analg. 2004;99:135–139. doi: 10.1213/01.ANE.0000115150.83395.48. [DOI] [PubMed] [Google Scholar]
98.Lavand’homme PM, Eisenach JC. Perioperative administration of the alpha2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression. Pain. 2003;105:247–254. doi: 10.1016/s0304-3959(03)00221-5. [DOI] [PubMed] [Google Scholar]
99.Lavand’ homme PM, Ma W, De Kock M, Eisenach JC. Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology. 2002;97:972–980. doi: 10.1097/00000542-200210000-00033. [DOI] [PubMed] [Google Scholar]
100.Hota D, Bansal V, Pattanaik S. Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find Exp Clin Pharmacol. 2007;29:443–446. doi: 10.1358/mf.2007.29.7.1074689. [DOI] [PubMed] [Google Scholar]
101.McCarson KE, Ralya A, Reisman SA, Enna SJ. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochem Pharmacol. 2005;71:196–202. doi: 10.1016/j.bcp.2005.10.026. [DOI] [PubMed] [Google Scholar]
102.Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355–363. doi: 10.1016/0304-3959(92)90041-9. [DOI] [PubMed] [Google Scholar]
103.Arguis MJ, Perez J, Martinez G, Ubre M, Gomar C. Contralateral neuropathic pain following a surgical model of unilateral nerve injury in rats. Reg Anesth Pain Med. 2008;33:211–216. doi: 10.1016/j.rapm.2007.12.003. [DOI] [PubMed] [Google Scholar]
104.Chung JM, Choi Y, Yoon YW, Na HS. Effects of age on behavioral signs of neuropathic pain in an experimental rat model. Neurosci Lett. 1995;183:54–57. doi: 10.1016/0304-3940(94)11113-w. [DOI] [PubMed] [Google Scholar]
105.Svensson C, Schaefers M, Jones TL, Powell HC, Yaksh TL, Sorkin LS. Age dependent change in allodynia and p38 MAPK activation following spinal nerve ligation. J Pain. 2004;5(suppl 1):33–33. [Google Scholar]
106.Wu G, Ringkamp M, Murinson BB, et al. Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci. 2002;22:7746–7753. doi: 10.1523/JNEUROSCI.22-17-07746.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]
107.Ali Z, Ringkamp M, Hartke TV, et al. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J Neurophysiol. 1999;81:455–466. doi: 10.1152/jn.1999.81.2.455. [DOI] [PubMed] [Google Scholar]
108.Schafers M, Sommer C, Geis C, Hagenacker T, Vandenabeele P, Sorkin LS. Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro. Neuroscience. 2008;157:414–423. doi: 10.1016/j.neuroscience.2008.08.067. [DOI] [PubMed] [Google Scholar]
109.Obata K, Yamanaka H, Dai Y, et al. Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion. Exp Neurol. 2004;188:149–160. doi: 10.1016/j.expneurol.2004.03.012. [DOI] [PubMed] [Google Scholar]
110.Obata K, Yamanaka H, Kobayashi K, et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci. 2004;24:10211–10222. doi: 10.1523/JNEUROSCI.3388-04.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]
111.Sheth RN, Dorsi MJ, Li Y, et al. Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat. Pain. 2002;96:63–72. doi: 10.1016/s0304-3959(01)00429-8. [DOI] [PubMed] [Google Scholar]
112.Li L, Xian CJ, Zhong JH, Zhou XF. Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Mol Cell Neurosci. 2003;23:232–250. doi: 10.1016/s1044-7431(03)00062-9. [DOI] [PubMed] [Google Scholar]
113.Kim SH, Na HS, Sheen K, Chung JM. Effects of sympathectomy on a rat model of peripheral neuropathy. Pain. 1993;55:85–92. doi: 10.1016/0304-3959(93)90187-T. [DOI] [PubMed] [Google Scholar]
114.Choi Y, Yoon YW, Na HS, Kim SH, Chung JM. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain. 1994;59:369–376. doi: 10.1016/0304-3959(94)90023-X. [DOI] [PubMed] [Google Scholar]
115.Chung K, Lee BH, Yoon YW, Chung JM. Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model. J Comp Neurol. 1996;376:241–252. doi: 10.1002/(SICI)1096-9861(19961209)376:2<241::AID-CNE6>3.0.CO;2-3. [DOI] [PubMed] [Google Scholar]
116.Ringkamp M, Eschenfelder S, Grethel EJ, et al. Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury. Pain. 1999;79:143–153. doi: 10.1016/s0304-3959(98)00186-9. [DOI] [PubMed] [Google Scholar]
117.Yoon YW, Lee DH, Lee BH, Chung K, Chung JM. Different strains and substrains of rats show different levels of neuropathic pain behaviors. Exp Brain Res. 1999;129:167–171. doi: 10.1007/s002210050886. [DOI] [PubMed] [Google Scholar]
118.Coyle DE, Sehlhorst CS, Behbehani MM. Intact female rats are more susceptible to the development of tactile allodynia than ovariectomized female rats following partial sciatic nerve ligation (PSNL) Neurosci Lett. 1996;203:37–40. doi: 10.1016/0304-3940(95)12259-1. [DOI] [PubMed] [Google Scholar]
119.DeLeo JA, Rutkowski MD. Gender differences in rat neuropathic pain sensitivity is dependent on strain. Neurosci Lett. 2000;282:197–199. doi: 10.1016/s0304-3940(00)00880-6. [DOI] [PubMed] [Google Scholar]
120.Chaplan SR, Bach FW, Shafer SL, Yaksh TL. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats [see comments] Anesthesiology. 1995;83:775–785. doi: 10.1097/00000542-199510000-00017. [DOI] [PubMed] [Google Scholar]
121.Dong XW, Jia Y, Lu SX, et al. The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain. Psychopharmacology (Berl) 2008;195:559–568. doi: 10.1007/s00213-007-0942-5. [DOI] [PubMed] [Google Scholar]
122.Chapman V, Ng J, Dickenson AH. A novel spinal action of mexiletine in spinal somatosensory transmission of nerve injured rats. Pain. 1998;77:289–303. doi: 10.1016/S0304-3959(98)00106-7. [DOI] [PubMed] [Google Scholar]
123.Zhang JM, Li H, Munir MA. Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine. Pain. 2004;109:143–149. doi: 10.1016/j.pain.2004.01.033. [DOI] [PubMed] [Google Scholar]
124.LaBuda CJ, Little PJ. Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J Neurosci Methods. 2005;144:175–181. doi: 10.1016/j.jneumeth.2004.11.008. [DOI] [PubMed] [Google Scholar]
125.Lee YW, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett. 1995;199:111–114. doi: 10.1016/0304-3940(95)12034-2. [DOI] [PubMed] [Google Scholar]
126.Field MJ, Bramwell S, Hughes J, Singh L. Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones? Pain. 1999;83:303–311. doi: 10.1016/s0304-3959(99)00111-6. [DOI] [PubMed] [Google Scholar]
127.Kontinen VK, Paananen S, Kalso E. Systemic morphine in the prevention of allodynia in the rat spinal nerve ligation model of neuropathic pain. Eur J Pain. 1998;2:35–42. doi: 10.1016/s1090-3801(98)90044-1. [DOI] [PubMed] [Google Scholar]
128.Suzuki R, Chapman V, Dickenson AH. The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain. Pain. 1999;80:215–228. doi: 10.1016/s0304-3959(98)00208-5. [DOI] [PubMed] [Google Scholar]
129.Zhao C, Tall JM, Meyer RA, Raja SN. Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats. Anesthesiology. 2004;100:905–911. doi: 10.1097/00000542-200404000-00021. [DOI] [PubMed] [Google Scholar]
130.Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther. 1995;272:207–214. [PubMed] [Google Scholar]
131.Wei H, Pertovaara A. Spinal and pontine alpha2-adrenoceptors have opposite effects on pain-related behavior in the neuropathic rat. Eur J Pharmacol. 2006;551:41–49. doi: 10.1016/j.ejphar.2006.08.064. [DOI] [PubMed] [Google Scholar]
132.Jones KL, Finn DP, Governo RJ, et al. Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain. Neuropharmacology. 2009;56:405–413. doi: 10.1016/j.neuropharm.2008.09.010. [DOI] [PubMed] [Google Scholar]
133.King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. J Pain. 2006;7:513–520. doi: 10.1016/j.jpain.2006.02.001. [DOI] [PubMed] [Google Scholar]
134.Rode F, Thomsen M, Brolos T, Jensen DG, Blackburn-Munro G, Bjerrum OJ. The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. Eur J Pharmacol. 2007;564:103–111. doi: 10.1016/j.ejphar.2007.02.009. [DOI] [PubMed] [Google Scholar]
135.Pertin M, Allchorne AJ, Beggah AT, Woolf CJ, Decosterd I. Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain. Mol Pain. 2007;3:21–21. doi: 10.1186/1744-8069-3-21. [DOI] [PMC free article] [PubMed] [Google Scholar]
136.Zhao C, Chen L, Tao YX, et al. Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury. J Pain. 2007;8:931–937. doi: 10.1016/j.jpain.2007.06.008. [DOI] [PubMed] [Google Scholar]
137.Blackburn-Munro G, Ibsen N, Erichsen HK. A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test. Eur J Pharmacol. 2002;445:231–238. doi: 10.1016/s0014-2999(02)01765-x. [DOI] [PubMed] [Google Scholar]
138.Decosterd I, Allchome A, Woolf CJ. Differential analgesic sensitivity of two distinct neuropathic pain models. Anesth Analg. 2004;99:457–463. doi: 10.1213/01.ANE.0000131967.69309.4F. [DOI] [PubMed] [Google Scholar]
139.Suter MR, Papaloizos M, Beide CB, et al. Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology. 2003;99:1402–1408. doi: 10.1097/00000542-200312000-00025. [DOI] [PubMed] [Google Scholar]
140.Erichsen HK, Blackbum-Munro G. Pharmacological characterisation of the spared nerve injury model of neuropathic pain. Pain. 2002;98:151–161. doi: 10.1016/s0304-3959(02)00039-8. [DOI] [PubMed] [Google Scholar]
141.Erichsen HK, Hao JX, Xu XJ, Blackburn-Munro G. A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain. Eur J Pharmacol. 2003;458:275–282. doi: 10.1016/s0014-2999(02)02792-9. [DOI] [PubMed] [Google Scholar]
142.Berman JS, Birch R, Anand P. Pain following human brachial plexus injury with spinal cord root avulsion and the effect of surgery. Pain. 1998;75:199–207. doi: 10.1016/s0304-3959(97)00220-0. [DOI] [PubMed] [Google Scholar]
143.Rodrigues-Filho R, Campos MM, Ferreira J, Santos AR, Bertelli JA, Calixto JB. Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain. Brain Res. 2004;1018:159–170. doi: 10.1016/j.brainres.2004.05.058. [DOI] [PubMed] [Google Scholar]
144.Gazelius B, Cui JG, Svensson M, Meyerson B, Linderoth B. Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. Neuroreport. 1996;7:2619–2623. doi: 10.1097/00001756-199611040-00042. [DOI] [PubMed] [Google Scholar]
145.Hao JX, Xu IS, Xu XJ, Wiesenfeld-Hallin Z. Effects of intrathecal morphine, clonidine and baclofen on allodynia after partial sciatic nerve injury in the rat. Acta Anaesthesiol Scand. 1999;43:1027–1034. doi: 10.1034/j.1399-6576.1999.431010.x. [DOI] [PubMed] [Google Scholar]
146.Kupers R, Yu W, Persson JK, Xu XJ, Wiesenfeld-Hallin Z. Photochemically-induced ischemia of the rat sciatic nerve produces a dose-dependent and highly reproducible mechanical, heat and cold allodynia, and signs of spontaneous pain. Pain. 1998;76:45–59. doi: 10.1016/s0304-3959(98)00022-0. [DOI] [PubMed] [Google Scholar]
147.Hao JX, Blakeman KH, Yu W, Hultenby K, Xu XJ, Wiesenfeld-Hallin Z. Development of a mouse model of neuropathic pain following photochemically induced ischemia in the sciatic nerve. Exp Neurol. 2000;163:231–238. doi: 10.1006/exnr.2000.7373. [DOI] [PubMed] [Google Scholar]
148.Xu XJ, Plesan A, Yu W, Hao JX, Wiesenfeld-Hallin Z. Possible impact of genetic differences on the development of neuropathic pain-like behaviors after unilateral sciatic nerve ischemic injury in rats. Pain. 2001;89:135–145. doi: 10.1016/s0304-3959(00)00356-0. [DOI] [PubMed] [Google Scholar]
149.Yu W, Kauppila T, Hultenby K, Persson JK, Xu XJ, Wiesenfeld-Hallin Z. Photochemically-induced ischemic injury of the rat sciatic nerve: a light- and electron microscopic study. J Peripher Nerv Syst. 2000;5:209–217. doi: 10.1046/j.1529-8027.2000.00024.x. [DOI] [PubMed] [Google Scholar]
150.Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain. 2004;112:94–105. doi: 10.1016/j.pain.2004.08.001. [DOI] [PubMed] [Google Scholar]
151.Xanthos DN, Coderre TJ. Sympathetic vasoconstrictor antagonism and vasodilatation relieve mechanical allodynia in rats with chronic postischemia pain. J Pain. 2008;9:423–433. doi: 10.1016/j.jpain.2007.12.005. [DOI] [PMC free article] [PubMed] [Google Scholar]
152.Aota Y, Onari K, An HS, Yoshikawa K. Dorsal root ganglia morphologic features in patients with hemiation of the nucleus pulposus: assessment using magnetic resonance myelography and clinical correlation. Spine. 2001;26:2125–2132. doi: 10.1097/00007632-200110010-00016. [DOI] [PubMed] [Google Scholar]
153.Hu SJ, Xing JL. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain. 1998;77:15–23. doi: 10.1016/S0304-3959(98)00067-0. [DOI] [PubMed] [Google Scholar]
154.Zhang JM, Song XJ, LaMotte RH. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. J Neurophysiol. 1999;82:3359–3366. doi: 10.1152/jn.1999.82.6.3359. [DOI] [PubMed] [Google Scholar]
155.Song XJ, Vizcarra C, Xu DS, Rupert RL, Wong ZN. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. J Neurophysiol. 2003;89:2185–2193. doi: 10.1152/jn.00802.2002. [DOI] [PubMed] [Google Scholar]
156.Ma C, Greenquist KW, Lamotte RH. Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. J Neurophysiol. 2006;95:2098–2107. doi: 10.1152/jn.00748.2005. [DOI] [PubMed] [Google Scholar]
157.Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol. 1999;82:3347–3358. doi: 10.1152/jn.1999.82.6.3347. [DOI] [PubMed] [Google Scholar]
158.Zhang JM, Li H, Brull SJ. Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat. J Neurophysiol. 2000;84:798–805. doi: 10.1152/jn.2000.84.2.798. [DOI] [PubMed] [Google Scholar]
159.Jancalek R, Dubovy P. An experimental animal model of spinal root compression syndrome: an analysis of morphological changes of myelinated axons during compression radiculopathy and after decompression. Exp Brain Res. 2007;179:111–119. doi: 10.1007/s00221-006-0771-5. [DOI] [PubMed] [Google Scholar]
160.Massie JB, Huang B, Malkmus S, et al. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004;137:283–289. doi: 10.1016/j.jneumeth.2004.02.036. [DOI] [PubMed] [Google Scholar]
161.Aprill C, Bogduk N. High-intensity zone: a diagnostic sign of painful lumbar disc on magnetic resonance imaging. Br J Radiol. 1992;65:361–369. doi: 10.1259/0007-1285-65-773-361. [DOI] [PubMed] [Google Scholar]
162.Videman T, Nurminen M. The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine. 2004;29:2668–2676. doi: 10.1097/01.brs.0000146461.27105.2b. [DOI] [PubMed] [Google Scholar]
163.Olmarker K, Storkson R, Berge OG. Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc hemiation. Spine. 2002;27:1312–1317. doi: 10.1097/00007632-200206150-00013. [DOI] [PubMed] [Google Scholar]
164.Olmarker K. Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats. Spine. 2008;33:850–855. doi: 10.1097/BRS.0b013e31816b46ca. [DOI] [PubMed] [Google Scholar]
165.Shamji MF, Allen KD, So S, et al. Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. Spine. 2009;34:648–654. doi: 10.1097/BRS.0b013e318197f013. [DOI] [PMC free article] [PubMed] [Google Scholar]
166.Hunt D, Hossain-Ibrahim K, Mason MR, et al. ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter. BMC Neurosci. 2004;5:9–9. doi: 10.1186/1471-2202-5-9. [DOI] [PMC free article] [PubMed] [Google Scholar]
167.Wright DE, Ryals JM, McCarson KE, Christianson JA. Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons. J Peripher Nerv Syst. 2004;9:242–254. doi: 10.1111/j.1085-9489.2004.09404.x. [DOI] [PubMed] [Google Scholar]
168.Jones E, Vinuela-Fernandez I, Eager RA, et al. Neuropathic changes in equine laminitis pain. Pain. 2007;132:321–331. doi: 10.1016/j.pain.2007.08.035. [DOI] [PubMed] [Google Scholar]

[CR1] 1.Sunderland S. Nerves and nerve injuries. Edinburgh London: Churchill Livingstone; 1972. [Google Scholar]

[CR2] 2.Weir-Mitchell S, Moorhouse GR, Keen WW. Gunshot wounds and other injuries of nerves. Philadephia: Lippincott; 1864. [Google Scholar]

[CR3] 3.Campbell JN, Meyer RA. Mechanisms of neuropathic pain. Neuron. 2006;52:77–92. doi: 10.1016/j.neuron.2006.09.021. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR4] 4.Zimmermann M. Pathobiology of neuropathic pain. Eur J Pharmacol. 2001;429:23–37. doi: 10.1016/s0014-2999(01)01303-6. [DOI] [PubMed] [Google Scholar]

[CR5] 5.Schoffnegger D, Ruscheweyh R, Sandkuhler J. Spread of excitation across modality borders in spinal dorsal horn of neuropathic rats. Pain. 2008;135:300–310. doi: 10.1016/j.pain.2007.12.016. [DOI] [PubMed] [Google Scholar]

[CR6] 6.Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. Clin Ther. 2003;25:81–104. doi: 10.1016/s0149-2918(03)90011-7. [DOI] [PubMed] [Google Scholar]

[CR7] 7.Gold MS. Sodium channels and pain therapy. Curr Opin Anaesthesiol. 2000;13:565–572. doi: 10.1097/00001503-200010000-00014. [DOI] [PubMed] [Google Scholar]

[CR8] 8.Saarto T, Wiffen PJ. Antidepressants for neuropathic pain. Cochrane Database Syst Rev 2007:CD005454. [DOI] [PMC free article] [PubMed]

[CR9] 9.Eisenberg E, McNicol ED, Carr DB. Efficacy of mu-opioid agonists in the treatment of evoked neuropathic pain: systematic review of randomized controlled trials. Eur J Pain. 2006;10:667–676. doi: 10.1016/j.ejpain.2005.10.007. [DOI] [PubMed] [Google Scholar]

[CR10] 10.Nicholson B. Benefits of extended-release opioid analgesic formulations in the treatment of chronic pain. Pain Pract. 2009;9:71–81. doi: 10.1111/j.1533-2500.2008.00232.x. [DOI] [PubMed] [Google Scholar]

[CR11] 11.Raber P, Devor M. Social variables affect phenotype in the neuroma model of neuropathic pain. Pain. 2002;97:139–150. doi: 10.1016/s0304-3959(02)00013-1. [DOI] [PubMed] [Google Scholar]

[CR12] 12.Chesler EJ, Wilson SG, Lariviere WR, Rodriguez-Zas SL, Mogil JS. Identification and ranking of genetic and laboratory environment factors influencing a behavioral trait, thermal nociception, via computational analysis of a large data archive. Neurosci Biobehav Rev. 2002;26:907–923. doi: 10.1016/s0149-7634(02)00103-3. [DOI] [PubMed] [Google Scholar]

[CR13] 13.Vissers K, De Jongh R, Hoffmann V, Heylen R, Crul B, Meert T. Internal and external factors affecting the development of neuropathic pain in rodents. Is it all about pain? Pain Pract. 2003;3:326–342. doi: 10.1111/j.1530-7085.2003.03037.x. [DOI] [PubMed] [Google Scholar]

[CR14] 14.Wall PD, Devor M, Inbal R, et al. Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain. 1979;7:103–111. doi: 10.1016/0304-3959(79)90002-2. [DOI] [PubMed] [Google Scholar]

[CR15] 15.Attal N, Filliatreau G, Perrot S, Jazat F, Di Giamberardino L, Guilbaud G. Behavioural pain-related disorders and contribution of the saphenous nerve in crush and chronic constriction injury of the rat sciatic nerve. Pain. 1994;59:301–312. doi: 10.1016/0304-3959(94)90083-3. [DOI] [PubMed] [Google Scholar]

[CR16] 16.DeLeo JA, Coombs DW, Willenbring S, et al. Characterization of a neuropathic pain model: sciatic cryoneurolysis in the rat. Pain. 1994;56:9–16. doi: 10.1016/0304-3959(94)90145-7. [DOI] [PubMed] [Google Scholar]

[CR17] 17.Levitt M. Dysesthesias and self-mutilation in humans and subhumans: a review of clinical and experimental studies. Brain Res. 1985;357:247–290. doi: 10.1016/0165-0173(85)90027-x. [DOI] [PubMed] [Google Scholar]

[CR18] 18.Walczak JS, Pichette V, Leblond F, Desbiens K, Beaulieu P. Behavioral, pharmacological and molecular characterization of the saphenous nerve partial ligation: a new model of neuropathic pain. Neuroscience. 2005;132:1093–1102. doi: 10.1016/j.neuroscience.2005.02.010. [DOI] [PubMed] [Google Scholar]

[CR19] 19.Decosterd I, Woolf CJ. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain. 2000;87:149–158. doi: 10.1016/S0304-3959(00)00276-1. [DOI] [PubMed] [Google Scholar]

[CR20] 20.Hofmann HA, De Vry J, Siegling A, Spreyer P, Denzer D. Pharmacological sensitivity and gene expression analysis of the tibial nerve injury model of neuropathic pain. Eur J Pharmacol. 2003;470:17–25. doi: 10.1016/s0014-2999(03)01753-9. [DOI] [PubMed] [Google Scholar]

[CR21] 21.Coderre TJ, Grimes RW, Melzack R. Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain. Pain. 1986;26:61–84. doi: 10.1016/0304-3959(86)90174-0. [DOI] [PubMed] [Google Scholar]

[CR22] 22.Blumenkopf B, Lipman JJ. Studies in autotomy: its pathophysiology and usefulness as a model of chronic pain. Pain. 1991;45:203–209. doi: 10.1016/0304-3959(91)90189-5. [DOI] [PubMed] [Google Scholar]

[CR23] 23.Wagner R, DeLeo JA, Coombs DW, Myers RR. Gender differences in autotomy following sciatic cryoneurolysis in the rat. Physiol Behav. 1995;58:37–41. doi: 10.1016/0031-9384(95)00037-j. [DOI] [PubMed] [Google Scholar]

[CR24] 24.Inbal R, Devor M, Tuchendler O, Lieblich I. Autotomy following nerve injury: genetic factors in the development of chronic pain. Pain. 1980;9:327–337. doi: 10.1016/0304-3959(80)90047-0. [DOI] [PubMed] [Google Scholar]

[CR25] 25.Devor M, Raber P. Heritability of symptoms in an experimental model of neuropathic pain. Pain. 1990;42:51–67. doi: 10.1016/0304-3959(90)91092-W. [DOI] [PubMed] [Google Scholar]

[CR26] 26.Zeltser R, Beilin B, Zaslansky R, Seltzer Z. Comparison of autotomy behavior induced in rats by various clinically-used neurectomy methods. Pain. 2000;89:19–24. doi: 10.1016/S0304-3959(00)00342-0. [DOI] [PubMed] [Google Scholar]

[CR27] 27.Dowdall T, Robinson I, Meert TF. Comparison of five different rat models of peripheral nerve injury. Pharmacol Biochem Behav. 2005;80:93–108. doi: 10.1016/j.pbb.2004.10.016. [DOI] [PubMed] [Google Scholar]

[CR28] 28.Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man [see comments] Pain. 1988;33:87–107. doi: 10.1016/0304-3959(88)90209-6. [DOI] [PubMed] [Google Scholar]

[CR29] 29.Maves TJ, Pechman PS, Gebhart GF, Meller ST. Possible chemical contribution from chronic-gut sutures produces disorders of pain sensation like those seen in man. Pain. 1993;54:57–69. doi: 10.1016/0304-3959(93)90100-4. [DOI] [PubMed] [Google Scholar]

[CR30] 30.Carlton SM, Dougherty PM, Pover CM, Coggeshall RE. Neuroma formation and numbers of axons in a rat model of experimental peripheral neuropathy. Neurosci Lett. 1991;131:88–92. doi: 10.1016/0304-3940(91)90343-r. [DOI] [PubMed] [Google Scholar]

[CR31] 31.Kajander KC, Bennett GJ. Onset of a painful peripheral neuropathy in rat: a partial and differential deafferentation and spontaneous discharge in A beta and A delta primary afferent neurons. J Neurophysiol. 1992;68:734–744. doi: 10.1152/jn.1992.68.3.734. [DOI] [PubMed] [Google Scholar]

[CR32] 32.Sommer C, Lalonde A, Heckman HM, Rodriguez M, Myers RR. Quantitative neuropathology of a focal nerve injury causing hyperalgesia. J Neuropath Exp Neurol. 1995;54:635–643. doi: 10.1097/00005072-199509000-00004. [DOI] [PubMed] [Google Scholar]

[CR33] 33.Myers RR, Heckman HM, Rodriguez M. Reduced hyperalgesia in nerve-injured WLD mice: Relationship to nerve fiber phagocytosis, axonal degeneration and regeneration in normal mice. Exptl Neurol. 1996;141:94–101. doi: 10.1006/exnr.1996.0142. [DOI] [PubMed] [Google Scholar]

[CR34] 34.Grelik C, Bennett GJ, Ribeiro-da-Silva A. Autonomic fibre sprouting and changes in nociceptive sensory innervation in the rat lower lip skin following chronic constriction injury. Eur J Neurosci. 2005;21:2475–2487. doi: 10.1111/j.1460-9568.2005.04089.x. [DOI] [PubMed] [Google Scholar]

[CR35] 35.Vos BP, Benoist JM, Gautron M, Guilbaud G. Changes in neuronal activities in the two ventral posterior medial thalamic nuclei in an experimental model of trigeminal pain in the rat by constriction of one infraorbital nerve. Somatosens Mot Res. 2000;17:109–122. doi: 10.1080/08990220050020535. [DOI] [PubMed] [Google Scholar]

[CR36] 36.Kitagawa J, Takeda M, Suzuki I, et al. Mechanisms involved in modulation of trigeminal primary afferent activity in rats with peripheral mononeuropathy. Eur J Neurosci. 2006;24:1976–1986. doi: 10.1111/j.1460-9568.2006.05065.x. [DOI] [PubMed] [Google Scholar]

[CR37] 37.Sommer C, Schmidt C, George A, Toyka KV. A metalloprotease-inhibitor reduces pain associated behavior in mice with experimental neuropathy. Neurosci Lett. 1997;237:45–48. doi: 10.1016/s0304-3940(97)00813-6. [DOI] [PubMed] [Google Scholar]

[CR38] 38.Carlton SM, Lekan HA, Kim SH, Chung JM. Behavioral manifestations of an experimental model for peripheral neuropathy produced by spinal nerve ligation in the primate. Pain. 1994;56:155–166. doi: 10.1016/0304-3959(94)90090-6. [DOI] [PubMed] [Google Scholar]

[CR39] 39.Vierck CJ, Acosta-Rua AJ, Johnson RD. Bilateral chronic constriction of the sciatic nerve: a model of long-term cold hyperalgesia. J Pain. 2005;6:507–517. doi: 10.1016/j.jpain.2005.03.003. [DOI] [PubMed] [Google Scholar]

[CR40] 40.Jasmin L, Kohan L, Franssen M, Janni G, Goff JR. The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models. Pain. 1998;75:367–382. doi: 10.1016/s0304-3959(98)00017-7. [DOI] [PubMed] [Google Scholar]

[CR41] 41.Covey WC, Ignatowski TA, Renauld AE, Knight PR, Nader ND, Spengler RN. Expression of neuron-associated tumor necrosis factor alpha in the brain is increased during persistent pain. Reg Anesth Pain Med. 2002;27:357–366. doi: 10.1053/rapm.2002.31930. [DOI] [PubMed] [Google Scholar]

[CR42] 42.Vogel C, Mossner R, Gerlach M, et al. Absence of thermal hyperalgesia in serotonin transporter-deficient mice. J Neurosci. 2003;23:708–715. doi: 10.1523/JNEUROSCI.23-02-00708.2003. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR43] 43.Hutchinson MR, Zhang Y, Brown K, et al. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4) Eur J Neurosci. 2008;28:20–29. doi: 10.1111/j.1460-9568.2008.06321.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR44] 44.Milligan ED, Sloane EM, Langer SJ, et al. Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10. Mol Pain. 2005;1:9–9. doi: 10.1186/1744-8069-1-9. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR45] 45.Kingery WS, Lu JD, Roffers JA, Kell DR. The resolution of neuropathic hyperalgesia following motor and sensory functional recovery in sciatic axonotmetic mononeuropathies. Pain. 1994;58:157–168. doi: 10.1016/0304-3959(94)90196-1. [DOI] [PubMed] [Google Scholar]

[CR46] 46.Bullens P, Daemen M, Freling G, Kitslaar P, Van den Wildenberg F, Kurvers H. Motor dysfunction and reflex sympathetic dystrophy. Bilateral motor denervation in an experimental model. Acta Orthop Belg. 1998;64:218–223. [PubMed] [Google Scholar]

[CR47] 47.Myers RR, Yamamoto T, Yaksh TL, Powell HC. The role of focal nerve ischemia and Wallerian degeneration in peripheral nerve injury producing hyperesthesia. Anesthesiology. 1993;78:308–316. doi: 10.1097/00000542-199302000-00015. [DOI] [PubMed] [Google Scholar]

[CR48] 48.Jacobs JM, Ro LS. A morphological study of experimental mononeuropathy in the rat: early ischemic changes. J Neurol Sci. 1994;127:143–152. doi: 10.1016/0022-510x(94)90066-3. [DOI] [PubMed] [Google Scholar]

[CR49] 49.Ramer MS, Bisby MA. Rapid sprouting of sympathetic axons in dorsal root ganglia of rats with a chronic constriction injury. Pain. 1997;70:237–244. doi: 10.1016/s0304-3959(97)03331-9. [DOI] [PubMed] [Google Scholar]

[CR50] 50.McLachlan EM, Janig W, Devor M, Michaelis M. Peripheral nerve injury triggers noradrenergic sprouting within dorsal root ganglia. Nature. 1993;363:543–546. doi: 10.1038/363543a0. [DOI] [PubMed] [Google Scholar]

[CR51] 51.Ramer MS, French GD, Bisby MA. Wallerian degeneration is required for both neuropathic pain and sympathetic sprouting into the DRG. Pain. 1997;72:71–78. doi: 10.1016/s0304-3959(97)00019-5. [DOI] [PubMed] [Google Scholar]

[CR52] 52.Neil A, Attal N, Guilbaud G. Effects of guanethidine on sensitization to natural stimuli and self-mutilating behaviour in rats with a peripheral neuropathy. Brain Res. 1991;565:237–246. doi: 10.1016/0006-8993(91)91655-k. [DOI] [PubMed] [Google Scholar]

[CR53] 53.Perrot S, Attal N, Ardid D, Guilbaud G. Are mechanical and cold allodynia in mononeuropathic and arthritic rats relieved by systemic treatment with calcitonin or guanethidine? Pain. 1993;52:41–47. doi: 10.1016/0304-3959(93)90111-2. [DOI] [PubMed] [Google Scholar]

[CR54] 54.Tall JM, Stuesse SL, Cruce WL, Crisp T. Gender and the behavioral manifestations of neuropathic pain. Pharmacol Biochem Behav. 2001;68:99–104. doi: 10.1016/s0091-3057(00)00461-5. [DOI] [PubMed] [Google Scholar]

[CR55] 55.Stevens CW, Kajander KC, Bennett GJ, Seybold VS. Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain. 1991;46:315–326. doi: 10.1016/0304-3959(91)90114-D. [DOI] [PubMed] [Google Scholar]

[CR56] 56.Backonja MM, Miletic G, Miletic V. The effect of continuous morphine analgesia on chronic thermal hyperalgesia due to sciatic constriction injury in rats. Neurosci Lett. 1995;196:61–64. doi: 10.1016/0304-3940(95)11844-m. [DOI] [PubMed] [Google Scholar]

[CR57] 57.Catheline G, Kayser V, Idanpaan-Heikkila JJ, Guilbaud G. The antinociceptive activity of kappa-but not delta-opioid receptor agonists is maintained in morphine-tolerant neuropathic rats. Eur J Pharmacol. 1996;318:273–281. doi: 10.1016/s0014-2999(96)00790-x. [DOI] [PubMed] [Google Scholar]

[CR58] 58.Catheline G, Kayser V, Guilbaud G. Further evidence for a peripheral component in the enhanced antinociceptive effect of systemic morphine in mononeuropathic rats: involvement of kappa-, but not delta-opioid receptors. Eur J Pharmacol. 1996;315:135–143. doi: 10.1016/s0014-2999(96)00629-2. [DOI] [PubMed] [Google Scholar]

[CR59] 59.Catheline G, Le Guen S, Besson JM. Intravenous morphine does not modify dorsal horn touch-evoked allodynia in the mononeuropathic rat: a Fos study. Pain. 2001;92:389–398. doi: 10.1016/S0304-3959(01)00283-4. [DOI] [PubMed] [Google Scholar]

[CR60] 60.Nielsen CK, Ross FB, Lotfipour S, Saini KS, Edwards SR, Smith MT. Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain. Pain. 2007;132:289–300. doi: 10.1016/j.pain.2007.03.022. [DOI] [PubMed] [Google Scholar]

[CR61] 61.Leiphart JW, Dills CV, Zikel OM, Kim DL, Levy RM. A comparison of intrathecally administered narcotic and nonnarcotic analgesics for experimental chronic neuropathic pain. J Neurosurg. 1995;82:595–599. doi: 10.3171/jns.1995.82.4.0595. [DOI] [PubMed] [Google Scholar]

[CR62] 62.Yamamoto T, Yaksh TL. Spinal pharmacology of thermal hyperesthesia induced by incomplete ligation of sciatic nerve. I. Opioid and nonopioid receptors. Anesthesiology. 1991;75:817–826. doi: 10.1097/00000542-199111000-00014. [DOI] [PubMed] [Google Scholar]

[CR63] 63.Dougherty PM, Garrison CJ, Carlton SM. Differential influence of local anesthetic upon two models of experimentally induced peripheral mononeuropathy in the rat. Brain Res. 1992;570:109–115. doi: 10.1016/0006-8993(92)90570-y. [DOI] [PubMed] [Google Scholar]

[CR64] 64.Sotgiu ML, Castagna A, Lacerenza M, Marchettini P. Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy. Pain. 1995;61:3–10. doi: 10.1016/0304-3959(94)00120-4. [DOI] [PubMed] [Google Scholar]

[CR65] 65.Xie W, Strong JA, Meij JT, Zhang JM, Yu L. Neuropathic pain: early spontaneous afferent activity is the trigger. Pain. 2005;116:243–256. doi: 10.1016/j.pain.2005.04.017. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR66] 66.Sotgiu ML, Biella G, Castagna A, Lacerenza M, Marchettini P. Different time-courses of i.v. lidocaine effect on ganglionic and spinal units in neuropathic rats. Neuroreport. 1994;5:873–876. doi: 10.1097/00001756-199404000-00005. [DOI] [PubMed] [Google Scholar]

[CR67] 67.Omana-Zapata I, Khabbaz MA, Hunter JC, Bley KR. QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Research. 1997;771:228–237. doi: 10.1016/s0006-8993(97)00770-1. [DOI] [PubMed] [Google Scholar]

[CR68] 68.Smith LJ, Shih A, Miletic G, Miletic V. Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain. 2002;97:267–273. doi: 10.1016/S0304-3959(02)00028-3. [DOI] [PubMed] [Google Scholar]

[CR69] 69.Abram SE, Yaksh TL. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology. 1994;80:383–391. [PubMed] [Google Scholar]

[CR70] 70.Datta S, Waghray T, Torres M, Glusman S. Amiodarone decreases heat, cold, and mechanical hyperalgesia in a rat model of neuropathic pain. Anesth Analg. 2004;98:178–184. doi: 10.1213/01.ANE.0000093223.35824.23. [DOI] [PubMed] [Google Scholar]

[CR71] 71.Cui JC, Linderoth B, Meyerson BA. Incidence of mononeuropathy in rats is influenced by pre-emptive alteration of spinal excitability. Eur J Pain. 1997;1:53–59. doi: 10.1016/s1090-3801(97)90053-7. [DOI] [PubMed] [Google Scholar]

[CR72] 72.Tian J, Gu Y, Su D, Wu Y, Wang X. Effects of intrathecal lidocaine on hyperalgesia and allodynia following chronic constriction injury in rats. Eur J Pain. 2009;13:130–137. doi: 10.1016/j.ejpain.2008.03.013. [DOI] [PubMed] [Google Scholar]

[CR73] 73.Chen Y, Shu Y, Zhao Z. Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat. Neuroreport. 1999;10:2779–2782. doi: 10.1097/00001756-199909090-00015. [DOI] [PubMed] [Google Scholar]

[CR74] 74.Ma W, Eisenach JC. Chronic constriction injury of sciatic nerve induces the up-regulation of descending inhibitory noradrenergic innervation to the lumbar dorsal horn of mice. Brain Res. 2003;970:110–118. doi: 10.1016/s0006-8993(03)02293-5. [DOI] [PubMed] [Google Scholar]

[CR75] 75.Leiphart JW, Dills CV, Levy RM. Alpha2-adrenergic receptor subtype specificity of intrathecally administered tizanidine used for analgesia for neuropathic pain. J Neurosurg. 2004;101:641–647. doi: 10.3171/jns.2004.101.4.0641. [DOI] [PubMed] [Google Scholar]

[CR76] 76.Levy R, Leiphart J, Dills C. Analgesic action of acute and chronic intraspinally administered opiate and alpha 2-adrenergic agonists in chronic neuropathic pain. Stereotact Funct Neurosurg. 1994;62:279–289. doi: 10.1159/000098633. [DOI] [PubMed] [Google Scholar]

[CR77] 77.Munglani R, Bond A, Smith GD, et al. Changes in neuronal markers in a mononeuropathic rat model relationship between neuropeptide Y, pre-emptive drug treatment and long-term mechanical hyperalgesia. Pain. 1995;63:21–31. doi: 10.1016/0304-3959(95)00013-I. [DOI] [PubMed] [Google Scholar]

[CR78] 78.Hord AH, Denson DD, Stowe B, Haygood RM. alpha-1 and alpha-2 adrenergic antagonists relieve thermal hyperalgesia in experimental mononeuropathy from chronic constriction injury. Anesth Analg. 2001;92:1558–1562. doi: 10.1097/00000539-200106000-00042. [DOI] [PubMed] [Google Scholar]

[CR79] 79.Lang E, Hord AH, Denson D. Venlafaxine hydrochloride (Effexor) relieves thermal hyperalgesia in rats with an experimental mononeuropathy. Pain. 1996;68:151–155. doi: 10.1016/S0304-3959(96)03223-X. [DOI] [PubMed] [Google Scholar]

[CR80] 80.Ikeda T, Ishida Y, Naono R, et al. Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain. Neurosci Res. 2009;63:42–46. doi: 10.1016/j.neures.2008.10.002. [DOI] [PubMed] [Google Scholar]

[CR81] 81.Yasuda T, Iwamoto T, Ohara M, et al. The novel analgesic compound OT-7100 (5-n-butyl-7-(3,4,5-trimethoxybenzoylamino) pyrazolo[1,5-a]pyrimid ine) attenuates mechanical nociceptive responses in animal models of acute and peripheral neuropathic hyperalgesia. Jpn J Pharmacol. 1999;79:65–73. doi: 10.1254/jjp.79.65. [DOI] [PubMed] [Google Scholar]

[CR82] 82.Nielsen CK, Lewis RJ, Alewood D, et al. Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain. Pain. 2005;118:112–124. doi: 10.1016/j.pain.2005.08.002. [DOI] [PubMed] [Google Scholar]

[CR83] 83.Seltzer Z, Dubner R, Shir Y. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain. 1990;43:205–218. doi: 10.1016/0304-3959(90)91074-S. [DOI] [PubMed] [Google Scholar]

[CR84] 84.Xu M, Aita M, Chavkin C. Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions. J Pain. 2008;9:1036–1048. doi: 10.1016/j.jpain.2008.06.006. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR85] 85.Shinoda M, Kawashima K, Ozaki N, Asai H, Nagamine K, Sugiura Y. P2X3 receptor mediates heat hyperalgesia in a rat model of trigeminal neuropathic pain. J Pain. 2007;8:588–597. doi: 10.1016/j.jpain.2007.03.001. [DOI] [PubMed] [Google Scholar]

[CR86] 86.Matsuzawa-Yanagida K, Narita M, Nakajima M, et al. Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites. Neuropsychopharmacology. 2008;33:1952–1965. doi: 10.1038/sj.npp.1301590. [DOI] [PubMed] [Google Scholar]

[CR87] 87.Sinnott CJ, Garfield JM, Strichartz GR. Differential efficacy of intravenous lidocaine in alleviating ipsilateral versus contralateral neuropathic pain in the rat. Pain. 1999;80:521–531. doi: 10.1016/S0304-3959(98)00245-0. [DOI] [PubMed] [Google Scholar]

[CR88] 88.Seltzer Z, Shir Y. Sympathetically-maintained causalgiform disorders in a model for neuropathic pain: a review. J Basic Clin Physiol Pharmacol. 1991;2:17–61. doi: 10.1515/jbcpp.1991.2.1-2.17. [DOI] [PubMed] [Google Scholar]

[CR89] 89.Shir Y, Seltzer Z. Heat hyperalgesia following partial sciatic ligation in rats: interacting nature and nurture. Neuroreport. 2001;12:809–813. doi: 10.1097/00001756-200103260-00038. [DOI] [PubMed] [Google Scholar]

[CR90] 90.Fecho K, Valtschanoff JG. Acute inflammatory and neuropathic pain in Lewis and Fischer rats. J Neuroendocrinol. 2006;18:504–513. doi: 10.1111/j.1365-2826.2006.01442.x. [DOI] [PubMed] [Google Scholar]

[CR91] 91.Shir Y, Seltzer Z. A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neuroscience Letters. 1990;115:62–67. doi: 10.1016/0304-3940(90)90518-e. [DOI] [PubMed] [Google Scholar]

[CR92] 92.Ma W, Quirion R. Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus. Pain. 2002;99:175–184. doi: 10.1016/s0304-3959(02)00097-0. [DOI] [PubMed] [Google Scholar]

[CR93] 93.Coyle DE. Partial peripheral nerve injury leads to activation of astroglia and microglia which parallels the development of allodynic behavior. Glia. 1998;23:75–83. [PubMed] [Google Scholar]

[CR94] 94.Ma W, Bisby MA. Partial sciatic nerve transection induced tyrosine hydroxidase immunoreactive axon sprouting around both injured and spared dorsal root ganglion neurons which project to the gracile nucleus in middle-aged rats. Neurosci Lett. 1999;275:117–120. doi: 10.1016/s0304-3940(99)00746-6. [DOI] [PubMed] [Google Scholar]

[CR95] 95.Tracey DJ, Cunningham JE, Romm MA. Peripheral hyperalgesia in experimental neuropathy: mediation by alpha 2-adrenoreceptors on post-ganglionic sympathetic terminals. Pain. 1995;60:317–327. doi: 10.1016/0304-3959(94)00141-z. [DOI] [PubMed] [Google Scholar]

[CR96] 96.Ma W, Du W, Eisenach JC. Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac. Anesthesiology. 2003;98:203–208. doi: 10.1097/00000542-200301000-00031. [DOI] [PubMed] [Google Scholar]

[CR97] 97.Schechtmann G, Wallin J, Meyerson BA, Linderoth B. Intrathecal clonidine potentiates suppression of tactile hypersensitivity by spinal cord stimulation in a model of neuropathy. Anesth Analg. 2004;99:135–139. doi: 10.1213/01.ANE.0000115150.83395.48. [DOI] [PubMed] [Google Scholar]

[CR98] 98.Lavand’homme PM, Eisenach JC. Perioperative administration of the alpha2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression. Pain. 2003;105:247–254. doi: 10.1016/s0304-3959(03)00221-5. [DOI] [PubMed] [Google Scholar]

[CR99] 99.Lavand’ homme PM, Ma W, De Kock M, Eisenach JC. Perineural alpha(2A)-adrenoceptor activation inhibits spinal cord neuroplasticity and tactile allodynia after nerve injury. Anesthesiology. 2002;97:972–980. doi: 10.1097/00000542-200210000-00033. [DOI] [PubMed] [Google Scholar]

[CR100] 100.Hota D, Bansal V, Pattanaik S. Evaluation of ketamine, nimodipine, gabapentin and imipramine in partial sciatic nerve transection model of neuropathic pain in rat: an experimental study. Methods Find Exp Clin Pharmacol. 2007;29:443–446. doi: 10.1358/mf.2007.29.7.1074689. [DOI] [PubMed] [Google Scholar]

[CR101] 101.McCarson KE, Ralya A, Reisman SA, Enna SJ. Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain. Biochem Pharmacol. 2005;71:196–202. doi: 10.1016/j.bcp.2005.10.026. [DOI] [PubMed] [Google Scholar]

[CR102] 102.Kim SH, Chung JM. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 1992;50:355–363. doi: 10.1016/0304-3959(92)90041-9. [DOI] [PubMed] [Google Scholar]

[CR103] 103.Arguis MJ, Perez J, Martinez G, Ubre M, Gomar C. Contralateral neuropathic pain following a surgical model of unilateral nerve injury in rats. Reg Anesth Pain Med. 2008;33:211–216. doi: 10.1016/j.rapm.2007.12.003. [DOI] [PubMed] [Google Scholar]

[CR104] 104.Chung JM, Choi Y, Yoon YW, Na HS. Effects of age on behavioral signs of neuropathic pain in an experimental rat model. Neurosci Lett. 1995;183:54–57. doi: 10.1016/0304-3940(94)11113-w. [DOI] [PubMed] [Google Scholar]

[CR105] 105.Svensson C, Schaefers M, Jones TL, Powell HC, Yaksh TL, Sorkin LS. Age dependent change in allodynia and p38 MAPK activation following spinal nerve ligation. J Pain. 2004;5(suppl 1):33–33. [Google Scholar]

[CR106] 106.Wu G, Ringkamp M, Murinson BB, et al. Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J Neurosci. 2002;22:7746–7753. doi: 10.1523/JNEUROSCI.22-17-07746.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR107] 107.Ali Z, Ringkamp M, Hartke TV, et al. Uninjured C-fiber nociceptors develop spontaneous activity and alpha-adrenergic sensitivity following L6 spinal nerve ligation in monkey. J Neurophysiol. 1999;81:455–466. doi: 10.1152/jn.1999.81.2.455. [DOI] [PubMed] [Google Scholar]

[CR108] 108.Schafers M, Sommer C, Geis C, Hagenacker T, Vandenabeele P, Sorkin LS. Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro. Neuroscience. 2008;157:414–423. doi: 10.1016/j.neuroscience.2008.08.067. [DOI] [PubMed] [Google Scholar]

[CR109] 109.Obata K, Yamanaka H, Dai Y, et al. Contribution of degeneration of motor and sensory fibers to pain behavior and the changes in neurotrophic factors in rat dorsal root ganglion. Exp Neurol. 2004;188:149–160. doi: 10.1016/j.expneurol.2004.03.012. [DOI] [PubMed] [Google Scholar]

[CR110] 110.Obata K, Yamanaka H, Kobayashi K, et al. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci. 2004;24:10211–10222. doi: 10.1523/JNEUROSCI.3388-04.2004. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR111] 111.Sheth RN, Dorsi MJ, Li Y, et al. Mechanical hyperalgesia after an L5 ventral rhizotomy or an L5 ganglionectomy in the rat. Pain. 2002;96:63–72. doi: 10.1016/s0304-3959(01)00429-8. [DOI] [PubMed] [Google Scholar]

[CR112] 112.Li L, Xian CJ, Zhong JH, Zhou XF. Lumbar 5 ventral root transection-induced upregulation of nerve growth factor in sensory neurons and their target tissues: a mechanism in neuropathic pain. Mol Cell Neurosci. 2003;23:232–250. doi: 10.1016/s1044-7431(03)00062-9. [DOI] [PubMed] [Google Scholar]

[CR113] 113.Kim SH, Na HS, Sheen K, Chung JM. Effects of sympathectomy on a rat model of peripheral neuropathy. Pain. 1993;55:85–92. doi: 10.1016/0304-3959(93)90187-T. [DOI] [PubMed] [Google Scholar]

[CR114] 114.Choi Y, Yoon YW, Na HS, Kim SH, Chung JM. Behavioral signs of ongoing pain and cold allodynia in a rat model of neuropathic pain. Pain. 1994;59:369–376. doi: 10.1016/0304-3959(94)90023-X. [DOI] [PubMed] [Google Scholar]

[CR115] 115.Chung K, Lee BH, Yoon YW, Chung JM. Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model. J Comp Neurol. 1996;376:241–252. doi: 10.1002/(SICI)1096-9861(19961209)376:2<241::AID-CNE6>3.0.CO;2-3. [DOI] [PubMed] [Google Scholar]

[CR116] 116.Ringkamp M, Eschenfelder S, Grethel EJ, et al. Lumbar sympathectomy failed to reverse mechanical allodynia- and hyperalgesia-like behavior in rats with L5 spinal nerve injury. Pain. 1999;79:143–153. doi: 10.1016/s0304-3959(98)00186-9. [DOI] [PubMed] [Google Scholar]

[CR117] 117.Yoon YW, Lee DH, Lee BH, Chung K, Chung JM. Different strains and substrains of rats show different levels of neuropathic pain behaviors. Exp Brain Res. 1999;129:167–171. doi: 10.1007/s002210050886. [DOI] [PubMed] [Google Scholar]

[CR118] 118.Coyle DE, Sehlhorst CS, Behbehani MM. Intact female rats are more susceptible to the development of tactile allodynia than ovariectomized female rats following partial sciatic nerve ligation (PSNL) Neurosci Lett. 1996;203:37–40. doi: 10.1016/0304-3940(95)12259-1. [DOI] [PubMed] [Google Scholar]

[CR119] 119.DeLeo JA, Rutkowski MD. Gender differences in rat neuropathic pain sensitivity is dependent on strain. Neurosci Lett. 2000;282:197–199. doi: 10.1016/s0304-3940(00)00880-6. [DOI] [PubMed] [Google Scholar]

[CR120] 120.Chaplan SR, Bach FW, Shafer SL, Yaksh TL. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats [see comments] Anesthesiology. 1995;83:775–785. doi: 10.1097/00000542-199510000-00017. [DOI] [PubMed] [Google Scholar]

[CR121] 121.Dong XW, Jia Y, Lu SX, et al. The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain. Psychopharmacology (Berl) 2008;195:559–568. doi: 10.1007/s00213-007-0942-5. [DOI] [PubMed] [Google Scholar]

[CR122] 122.Chapman V, Ng J, Dickenson AH. A novel spinal action of mexiletine in spinal somatosensory transmission of nerve injured rats. Pain. 1998;77:289–303. doi: 10.1016/S0304-3959(98)00106-7. [DOI] [PubMed] [Google Scholar]

[CR123] 123.Zhang JM, Li H, Munir MA. Decreasing sympathetic sprouting in pathologic sensory ganglia: a new mechanism for treating neuropathic pain using lidocaine. Pain. 2004;109:143–149. doi: 10.1016/j.pain.2004.01.033. [DOI] [PubMed] [Google Scholar]

[CR124] 124.LaBuda CJ, Little PJ. Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat. J Neurosci Methods. 2005;144:175–181. doi: 10.1016/j.jneumeth.2004.11.008. [DOI] [PubMed] [Google Scholar]

[CR125] 125.Lee YW, Chaplan SR, Yaksh TL. Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neurosci Lett. 1995;199:111–114. doi: 10.1016/0304-3940(95)12034-2. [DOI] [PubMed] [Google Scholar]

[CR126] 126.Field MJ, Bramwell S, Hughes J, Singh L. Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones? Pain. 1999;83:303–311. doi: 10.1016/s0304-3959(99)00111-6. [DOI] [PubMed] [Google Scholar]

[CR127] 127.Kontinen VK, Paananen S, Kalso E. Systemic morphine in the prevention of allodynia in the rat spinal nerve ligation model of neuropathic pain. Eur J Pain. 1998;2:35–42. doi: 10.1016/s1090-3801(98)90044-1. [DOI] [PubMed] [Google Scholar]

[CR128] 128.Suzuki R, Chapman V, Dickenson AH. The effectiveness of spinal and systemic morphine on rat dorsal horn neuronal responses in the spinal nerve ligation model of neuropathic pain. Pain. 1999;80:215–228. doi: 10.1016/s0304-3959(98)00208-5. [DOI] [PubMed] [Google Scholar]

[CR129] 129.Zhao C, Tall JM, Meyer RA, Raja SN. Antiallodynic effects of systemic and intrathecal morphine in the spared nerve injury model of neuropathic pain in rats. Anesthesiology. 2004;100:905–911. doi: 10.1097/00000542-200404000-00021. [DOI] [PubMed] [Google Scholar]

[CR130] 130.Yaksh TL, Pogrel JW, Lee YW, Chaplan SR. Reversal of nerve ligation-induced allodynia by spinal alpha-2 adrenoceptor agonists. J Pharmacol Exp Ther. 1995;272:207–214. [PubMed] [Google Scholar]

[CR131] 131.Wei H, Pertovaara A. Spinal and pontine alpha2-adrenoceptors have opposite effects on pain-related behavior in the neuropathic rat. Eur J Pharmacol. 2006;551:41–49. doi: 10.1016/j.ejphar.2006.08.064. [DOI] [PubMed] [Google Scholar]

[CR132] 132.Jones KL, Finn DP, Governo RJ, et al. Identification of discrete sites of action of chronic treatment with desipramine in a model of neuropathic pain. Neuropharmacology. 2009;56:405–413. doi: 10.1016/j.neuropharm.2008.09.010. [DOI] [PubMed] [Google Scholar]

[CR133] 133.King T, Rao S, Vanderah T, Chen Q, Vardanyan A, Porreca F. Differential blockade of nerve injury-induced shift in weight bearing and thermal and tactile hypersensitivity by milnacipran. J Pain. 2006;7:513–520. doi: 10.1016/j.jpain.2006.02.001. [DOI] [PubMed] [Google Scholar]

[CR134] 134.Rode F, Thomsen M, Brolos T, Jensen DG, Blackburn-Munro G, Bjerrum OJ. The importance of genetic background on pain behaviours and pharmacological sensitivity in the rat spared serve injury model of peripheral neuropathic pain. Eur J Pharmacol. 2007;564:103–111. doi: 10.1016/j.ejphar.2007.02.009. [DOI] [PubMed] [Google Scholar]

[CR135] 135.Pertin M, Allchorne AJ, Beggah AT, Woolf CJ, Decosterd I. Delayed sympathetic dependence in the spared nerve injury (SNI) model of neuropathic pain. Mol Pain. 2007;3:21–21. doi: 10.1186/1744-8069-3-21. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR136] 136.Zhao C, Chen L, Tao YX, et al. Lumbar sympathectomy attenuates cold allodynia but not mechanical allodynia and hyperalgesia in rats with spared nerve injury. J Pain. 2007;8:931–937. doi: 10.1016/j.jpain.2007.06.008. [DOI] [PubMed] [Google Scholar]

[CR137] 137.Blackburn-Munro G, Ibsen N, Erichsen HK. A comparison of the anti-nociceptive effects of voltage-activated Na+ channel blockers in the formalin test. Eur J Pharmacol. 2002;445:231–238. doi: 10.1016/s0014-2999(02)01765-x. [DOI] [PubMed] [Google Scholar]

[CR138] 138.Decosterd I, Allchome A, Woolf CJ. Differential analgesic sensitivity of two distinct neuropathic pain models. Anesth Analg. 2004;99:457–463. doi: 10.1213/01.ANE.0000131967.69309.4F. [DOI] [PubMed] [Google Scholar]

[CR139] 139.Suter MR, Papaloizos M, Beide CB, et al. Development of neuropathic pain in the rat spared nerve injury model is not prevented by a peripheral nerve block. Anesthesiology. 2003;99:1402–1408. doi: 10.1097/00000542-200312000-00025. [DOI] [PubMed] [Google Scholar]

[CR140] 140.Erichsen HK, Blackbum-Munro G. Pharmacological characterisation of the spared nerve injury model of neuropathic pain. Pain. 2002;98:151–161. doi: 10.1016/s0304-3959(02)00039-8. [DOI] [PubMed] [Google Scholar]

[CR141] 141.Erichsen HK, Hao JX, Xu XJ, Blackburn-Munro G. A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain. Eur J Pharmacol. 2003;458:275–282. doi: 10.1016/s0014-2999(02)02792-9. [DOI] [PubMed] [Google Scholar]

[CR142] 142.Berman JS, Birch R, Anand P. Pain following human brachial plexus injury with spinal cord root avulsion and the effect of surgery. Pain. 1998;75:199–207. doi: 10.1016/s0304-3959(97)00220-0. [DOI] [PubMed] [Google Scholar]

[CR143] 143.Rodrigues-Filho R, Campos MM, Ferreira J, Santos AR, Bertelli JA, Calixto JB. Pharmacological characterisation of the rat brachial plexus avulsion model of neuropathic pain. Brain Res. 2004;1018:159–170. doi: 10.1016/j.brainres.2004.05.058. [DOI] [PubMed] [Google Scholar]

[CR144] 144.Gazelius B, Cui JG, Svensson M, Meyerson B, Linderoth B. Photochemically induced ischaemic lesion of the rat sciatic nerve. A novel method providing high incidence of mononeuropathy. Neuroreport. 1996;7:2619–2623. doi: 10.1097/00001756-199611040-00042. [DOI] [PubMed] [Google Scholar]

[CR145] 145.Hao JX, Xu IS, Xu XJ, Wiesenfeld-Hallin Z. Effects of intrathecal morphine, clonidine and baclofen on allodynia after partial sciatic nerve injury in the rat. Acta Anaesthesiol Scand. 1999;43:1027–1034. doi: 10.1034/j.1399-6576.1999.431010.x. [DOI] [PubMed] [Google Scholar]

[CR146] 146.Kupers R, Yu W, Persson JK, Xu XJ, Wiesenfeld-Hallin Z. Photochemically-induced ischemia of the rat sciatic nerve produces a dose-dependent and highly reproducible mechanical, heat and cold allodynia, and signs of spontaneous pain. Pain. 1998;76:45–59. doi: 10.1016/s0304-3959(98)00022-0. [DOI] [PubMed] [Google Scholar]

[CR147] 147.Hao JX, Blakeman KH, Yu W, Hultenby K, Xu XJ, Wiesenfeld-Hallin Z. Development of a mouse model of neuropathic pain following photochemically induced ischemia in the sciatic nerve. Exp Neurol. 2000;163:231–238. doi: 10.1006/exnr.2000.7373. [DOI] [PubMed] [Google Scholar]

[CR148] 148.Xu XJ, Plesan A, Yu W, Hao JX, Wiesenfeld-Hallin Z. Possible impact of genetic differences on the development of neuropathic pain-like behaviors after unilateral sciatic nerve ischemic injury in rats. Pain. 2001;89:135–145. doi: 10.1016/s0304-3959(00)00356-0. [DOI] [PubMed] [Google Scholar]

[CR149] 149.Yu W, Kauppila T, Hultenby K, Persson JK, Xu XJ, Wiesenfeld-Hallin Z. Photochemically-induced ischemic injury of the rat sciatic nerve: a light- and electron microscopic study. J Peripher Nerv Syst. 2000;5:209–217. doi: 10.1046/j.1529-8027.2000.00024.x. [DOI] [PubMed] [Google Scholar]

[CR150] 150.Coderre TJ, Xanthos DN, Francis L, Bennett GJ. Chronic post-ischemia pain (CPIP): a novel animal model of complex regional pain syndrome-type I (CRPS-I; reflex sympathetic dystrophy) produced by prolonged hindpaw ischemia and reperfusion in the rat. Pain. 2004;112:94–105. doi: 10.1016/j.pain.2004.08.001. [DOI] [PubMed] [Google Scholar]

[CR151] 151.Xanthos DN, Coderre TJ. Sympathetic vasoconstrictor antagonism and vasodilatation relieve mechanical allodynia in rats with chronic postischemia pain. J Pain. 2008;9:423–433. doi: 10.1016/j.jpain.2007.12.005. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR152] 152.Aota Y, Onari K, An HS, Yoshikawa K. Dorsal root ganglia morphologic features in patients with hemiation of the nucleus pulposus: assessment using magnetic resonance myelography and clinical correlation. Spine. 2001;26:2125–2132. doi: 10.1097/00007632-200110010-00016. [DOI] [PubMed] [Google Scholar]

[CR153] 153.Hu SJ, Xing JL. An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain. 1998;77:15–23. doi: 10.1016/S0304-3959(98)00067-0. [DOI] [PubMed] [Google Scholar]

[CR154] 154.Zhang JM, Song XJ, LaMotte RH. Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion. J Neurophysiol. 1999;82:3359–3366. doi: 10.1152/jn.1999.82.6.3359. [DOI] [PubMed] [Google Scholar]

[CR155] 155.Song XJ, Vizcarra C, Xu DS, Rupert RL, Wong ZN. Hyperalgesia and neural excitability following injuries to central and peripheral branches of axons and somata of dorsal root ganglion neurons. J Neurophysiol. 2003;89:2185–2193. doi: 10.1152/jn.00802.2002. [DOI] [PubMed] [Google Scholar]

[CR156] 156.Ma C, Greenquist KW, Lamotte RH. Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. J Neurophysiol. 2006;95:2098–2107. doi: 10.1152/jn.00748.2005. [DOI] [PubMed] [Google Scholar]

[CR157] 157.Song XJ, Hu SJ, Greenquist KW, Zhang JM, LaMotte RH. Mechanical and thermal hyperalgesia and ectopic neuronal discharge after chronic compression of dorsal root ganglia. J Neurophysiol. 1999;82:3347–3358. doi: 10.1152/jn.1999.82.6.3347. [DOI] [PubMed] [Google Scholar]

[CR158] 158.Zhang JM, Li H, Brull SJ. Perfusion of the mechanically compressed lumbar ganglion with lidocaine reduces mechanical hyperalgesia and allodynia in the rat. J Neurophysiol. 2000;84:798–805. doi: 10.1152/jn.2000.84.2.798. [DOI] [PubMed] [Google Scholar]

[CR159] 159.Jancalek R, Dubovy P. An experimental animal model of spinal root compression syndrome: an analysis of morphological changes of myelinated axons during compression radiculopathy and after decompression. Exp Brain Res. 2007;179:111–119. doi: 10.1007/s00221-006-0771-5. [DOI] [PubMed] [Google Scholar]

[CR160] 160.Massie JB, Huang B, Malkmus S, et al. A preclinical post laminectomy rat model mimics the human post laminectomy syndrome. J Neurosci Methods. 2004;137:283–289. doi: 10.1016/j.jneumeth.2004.02.036. [DOI] [PubMed] [Google Scholar]

[CR161] 161.Aprill C, Bogduk N. High-intensity zone: a diagnostic sign of painful lumbar disc on magnetic resonance imaging. Br J Radiol. 1992;65:361–369. doi: 10.1259/0007-1285-65-773-361. [DOI] [PubMed] [Google Scholar]

[CR162] 162.Videman T, Nurminen M. The occurrence of anular tears and their relation to lifetime back pain history: a cadaveric study using barium sulfate discography. Spine. 2004;29:2668–2676. doi: 10.1097/01.brs.0000146461.27105.2b. [DOI] [PubMed] [Google Scholar]

[CR163] 163.Olmarker K, Storkson R, Berge OG. Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc hemiation. Spine. 2002;27:1312–1317. doi: 10.1097/00007632-200206150-00013. [DOI] [PubMed] [Google Scholar]

[CR164] 164.Olmarker K. Puncture of a lumbar intervertebral disc induces changes in spontaneous pain behavior: an experimental study in rats. Spine. 2008;33:850–855. doi: 10.1097/BRS.0b013e31816b46ca. [DOI] [PubMed] [Google Scholar]

[CR165] 165.Shamji MF, Allen KD, So S, et al. Gait abnormalities and inflammatory cytokines in an autologous nucleus pulposus model of radiculopathy. Spine. 2009;34:648–654. doi: 10.1097/BRS.0b013e318197f013. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR166] 166.Hunt D, Hossain-Ibrahim K, Mason MR, et al. ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter. BMC Neurosci. 2004;5:9–9. doi: 10.1186/1471-2202-5-9. [DOI] [PMC free article] [PubMed] [Google Scholar]

[CR167] 167.Wright DE, Ryals JM, McCarson KE, Christianson JA. Diabetes-induced expression of activating transcription factor 3 in mouse primary sensory neurons. J Peripher Nerv Syst. 2004;9:242–254. doi: 10.1111/j.1085-9489.2004.09404.x. [DOI] [PubMed] [Google Scholar]

[CR168] 168.Jones E, Vinuela-Fernandez I, Eager RA, et al. Neuropathic changes in equine laminitis pain. Pain. 2007;132:321–331. doi: 10.1016/j.pain.2007.08.035. [DOI] [PubMed] [Google Scholar]

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Behavioral models of pain states evoked by physical injury to the peripheral nerve

Linda S Sorkin

Tony L Yaksh

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Behavioral models of pain states evoked by physical injury to the peripheral nerve

Linda S Sorkin

Tony L Yaksh

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