Full Text
The Full Text of this article is available as a PDF (111.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Akaike T., Noguchi Y., Ijiri S., Setoguchi K., Suga M., Zheng Y. M., Dietzschold B., Maeda H. Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2448–2453. doi: 10.1073/pnas.93.6.2448. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bansal R. K., Goldsmith P. C., He Y., Zaloudek C. J., Ecker J. L., Riemer R. K. A decline in myometrial nitric oxide synthase expression is associated with labor and delivery. J Clin Invest. 1997 May 15;99(10):2502–2508. doi: 10.1172/JCI119434. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doherty T. M., Sher A. Defects in cell-mediated immunity affect chronic, but not innate, resistance of mice to Mycobacterium avium infection. J Immunol. 1997 May 15;158(10):4822–4831. [PubMed] [Google Scholar]
- Fang F. C. Perspectives series: host/pathogen interactions. Mechanisms of nitric oxide-related antimicrobial activity. J Clin Invest. 1997 Jun 15;99(12):2818–2825. doi: 10.1172/JCI119473. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fehr T., Schoedon G., Odermatt B., Holtschke T., Schneemann M., Bachmann M. F., Mak T. W., Horak I., Zinkernagel R. M. Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis. J Exp Med. 1997 Mar 3;185(5):921–931. doi: 10.1084/jem.185.5.921. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilkeson G. S., Mudgett J. S., Seldin M. F., Ruiz P., Alexander A. A., Misukonis M. A., Pisetsky D. S., Weinberg J. B. Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. J Exp Med. 1997 Aug 4;186(3):365–373. doi: 10.1084/jem.186.3.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guo F. H., De Raeve H. R., Rice T. W., Stuehr D. J., Thunnissen F. B., Erzurum S. C. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7809–7813. doi: 10.1073/pnas.92.17.7809. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guo F. H., Uetani K., Haque S. J., Williams B. R., Dweik R. A., Thunnissen F. B., Calhoun W., Erzurum S. C. Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest. 1997 Aug 15;100(4):829–838. doi: 10.1172/JCI119598. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Haddad E. K., Duclos A. J., Baines M. G. Early embryo loss is associated with local production of nitric oxide by decidual mononuclear cells. J Exp Med. 1995 Oct 1;182(4):1143–1151. doi: 10.1084/jem.182.4.1143. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hickey M. J., Sharkey K. A., Sihota E. G., Reinhardt P. H., Macmicking J. D., Nathan C., Kubes P. Inducible nitric oxide synthase-deficient mice have enhanced leukocyte-endothelium interactions in endotoxemia. FASEB J. 1997 Oct;11(12):955–964. doi: 10.1096/fasebj.11.12.9337148. [DOI] [PubMed] [Google Scholar]
- Huang Z., Huang P. L., Panahian N., Dalkara T., Fishman M. C., Moskowitz M. A. Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science. 1994 Sep 23;265(5180):1883–1885. doi: 10.1126/science.7522345. [DOI] [PubMed] [Google Scholar]
- Iadecola C., Zhang F., Casey R., Nagayama M., Ross M. E. Delayed reduction of ischemic brain injury and neurological deficits in mice lacking the inducible nitric oxide synthase gene. J Neurosci. 1997 Dec 1;17(23):9157–9164. doi: 10.1523/JNEUROSCI.17-23-09157.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- James S. L. Role of nitric oxide in parasitic infections. Microbiol Rev. 1995 Dec;59(4):533–547. doi: 10.1128/mr.59.4.533-547.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jia L., Bonaventura C., Bonaventura J., Stamler J. S. S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control. Nature. 1996 Mar 21;380(6571):221–226. doi: 10.1038/380221a0. [DOI] [PubMed] [Google Scholar]
- Karupiah G., Xie Q. W., Buller R. M., Nathan C., Duarte C., MacMicking J. D. Inhibition of viral replication by interferon-gamma-induced nitric oxide synthase. Science. 1993 Sep 10;261(5127):1445–1448. doi: 10.1126/science.7690156. [DOI] [PubMed] [Google Scholar]
- Kobzik L., Bredt D. S., Lowenstein C. J., Drazen J., Gaston B., Sugarbaker D., Stamler J. S. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol. 1993 Oct;9(4):371–377. doi: 10.1165/ajrcmb/9.4.371. [DOI] [PubMed] [Google Scholar]
- Kröncke K. D., Fehsel K., Kolb-Bachofen V. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol Chem Hoppe Seyler. 1995 Jun;376(6):327–343. doi: 10.1515/bchm3.1995.376.6.327. [DOI] [PubMed] [Google Scholar]
- Laubach V. E., Shesely E. G., Smithies O., Sherman P. A. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10688–10692. doi: 10.1073/pnas.92.23.10688. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lowenstein C. J., Glatt C. S., Bredt D. S., Snyder S. H. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6711–6715. doi: 10.1073/pnas.89.15.6711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lyons C. R., Orloff G. J., Cunningham J. M. Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. J Biol Chem. 1992 Mar 25;267(9):6370–6374. [PubMed] [Google Scholar]
- MacMicking J. D., Nathan C., Hom G., Chartrain N., Fletcher D. S., Trumbauer M., Stevens K., Xie Q. W., Sokol K., Hutchinson N. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 1995 May 19;81(4):641–650. doi: 10.1016/0092-8674(95)90085-3. [DOI] [PubMed] [Google Scholar]
- MacMicking J. D., North R. J., LaCourse R., Mudgett J. S., Shah S. K., Nathan C. F. Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5243–5248. doi: 10.1073/pnas.94.10.5243. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MacMicking J., Xie Q. W., Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol. 1997;15:323–350. doi: 10.1146/annurev.immunol.15.1.323. [DOI] [PubMed] [Google Scholar]
- McCafferty D. M., Mudgett J. S., Swain M. G., Kubes P. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology. 1997 Mar;112(3):1022–1027. doi: 10.1053/gast.1997.v112.pm9041266. [DOI] [PubMed] [Google Scholar]
- Michel T., Feron O. Nitric oxide synthases: which, where, how, and why? J Clin Invest. 1997 Nov 1;100(9):2146–2152. doi: 10.1172/JCI119750. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nathan C., Xie Q. W. Regulation of biosynthesis of nitric oxide. J Biol Chem. 1994 May 13;269(19):13725–13728. [PubMed] [Google Scholar]
- Nicholson S., Bonecini-Almeida M. da G., Lapa e Silva J. R., Nathan C., Xie Q. W., Mumford R., Weidner J. R., Calaycay J., Geng J., Boechat N. Inducible nitric oxide synthase in pulmonary alveolar macrophages from patients with tuberculosis. J Exp Med. 1996 May 1;183(5):2293–2302. doi: 10.1084/jem.183.5.2293. [DOI] [PMC free article] [PubMed] [Google Scholar]
- North R. J., Izzo A. A. Mycobacterial virulence. Virulent strains of Mycobacteria tuberculosis have faster in vivo doubling times and are better equipped to resist growth-inhibiting functions of macrophages in the presence and absence of specific immunity. J Exp Med. 1993 Jun 1;177(6):1723–1733. doi: 10.1084/jem.177.6.1723. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nozaki Y., Hasegawa Y., Ichiyama S., Nakashima I., Shimokata K. Mechanism of nitric oxide-dependent killing of Mycobacterium bovis BCG in human alveolar macrophages. Infect Immun. 1997 Sep;65(9):3644–3647. doi: 10.1128/iai.65.9.3644-3647.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pendino K. J., Laskin J. D., Shuler R. L., Punjabi C. J., Laskin D. L. Enhanced production of nitric oxide by rat alveolar macrophages after inhalation of a pulmonary irritant is associated with increased expression of nitric oxide synthase. J Immunol. 1993 Dec 15;151(12):7196–7205. [PubMed] [Google Scholar]
- Ruan J., Xie Q. w., Hutchinson N., Cho H., Wolfe G. C., Nathan C. Inducible nitric oxide synthase requires both the canonical calmodulin-binding domain and additional sequences in order to bind calmodulin and produce nitric oxide in the absence of free Ca2+. J Biol Chem. 1996 Sep 13;271(37):22679–22686. doi: 10.1074/jbc.271.37.22679. [DOI] [PubMed] [Google Scholar]
- Scharton-Kersten T. M., Yap G., Magram J., Sher A. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J Exp Med. 1997 Apr 7;185(7):1261–1273. doi: 10.1084/jem.185.7.1261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shimabukuro M., Ohneda M., Lee Y., Unger R. H. Role of nitric oxide in obesity-induced beta cell disease. J Clin Invest. 1997 Jul 15;100(2):290–295. doi: 10.1172/JCI119534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stenger S., Thüring H., Röllinghoff M., Bogdan C. Tissue expression of inducible nitric oxide synthase is closely associated with resistance to Leishmania major. J Exp Med. 1994 Sep 1;180(3):783–793. doi: 10.1084/jem.180.3.783. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tzeng E., Shears L. L., 2nd, Robbins P. D., Pitt B. R., Geller D. A., Watkins S. C., Simmons R. L., Billiar T. R. Vascular gene transfer of the human inducible nitric oxide synthase: characterization of activity and effects on myointimal hyperplasia. Mol Med. 1996 Mar;2(2):211–225. [PMC free article] [PubMed] [Google Scholar]
- Wei X. Q., Charles I. G., Smith A., Ure J., Feng G. J., Huang F. P., Xu D., Muller W., Moncada S., Liew F. Y. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature. 1995 Jun 1;375(6530):408–411. doi: 10.1038/375408a0. [DOI] [PubMed] [Google Scholar]
- Weyand C. M., Wagner A. D., Björnsson J., Goronzy J. J. Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis. J Clin Invest. 1996 Oct 1;98(7):1642–1649. doi: 10.1172/JCI118959. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wong J. M., Billiar T. R. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. Adv Pharmacol. 1995;34:155–170. doi: 10.1016/s1054-3589(08)61084-4. [DOI] [PubMed] [Google Scholar]
- Xie Q. W., Cho H. J., Calaycay J., Mumford R. A., Swiderek K. M., Lee T. D., Ding A., Troso T., Nathan C. Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. Science. 1992 Apr 10;256(5054):225–228. doi: 10.1126/science.1373522. [DOI] [PubMed] [Google Scholar]