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. 2017 Jan;112(Pt A):76–83. doi: 10.1016/j.neuropharm.2016.08.010

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — GluN2B- and GluN2D-containing receptors are involved in the induction of STP. (A) Tetanic stimulation (100 Hz, 1 s) induced both STP and LTP (open circles, n = 10). 50 μM D-AP5 (filled circles, n = 4) reliably blocks the induction of STP and LTP. 0.1 μM NVP (open triangles, n = 4) has no effect on the induction of potentiation whereas 1 μM NVP blocks both STP and LTP (filled triangles, n = 5). (B) STP is significantly reduced after pre-incubation with 1 μM Ro (filled squares, n = 4) whereas LTP is not affected. 10 μM Ro (open squares, n = 4) completely abolishes LTP. (D) 10 μM UBP (filled triangles, n = 4) reduces STP but spares LTP.