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. 2016 Oct 1;143(19):3514–3521. doi: 10.1242/dev.137398

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 6. — Shh represses polarizing region proliferation and promotes apoptosis. Pearson's χ² test reveals no significant difference in G1-phase cells in distal mesenchyme between untreated and HH20/21 cyclopamine-treated embryos at 48 h (P=0.732) and 72 h (P=0.0842, A). However, there is a significant difference in polarizing region cells at 48 h (P<0.0001) and 72 h (P<0.0001), indicating an increased rate of proliferation. Apoptosis is detectable in the posterior necrotic zone of untreated wing buds (B, n=6/6), but undetectable in HH20/21 cyclopamine-treated wing buds at 72 h (C, n=7/7). Scale bars: 500 μm.