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. 2016 Oct 27;4:e2635. doi: 10.7717/peerj.2635

Figure 5. Captive bubble activity of synthetic lung surfactants containing phospholipase-resistant lipids plus SP-B/C peptides.

Figure 5

Phospholipase-resistant synthetic surfactants containing 9:1 DEPN-8:PG-1 combined with 1.5% S-MB DATK + 1.5% SP-Css ion-lock 1 peptides together, or 3% of S-MB DATK alone, were studied for dynamic surface tension lowering activity on a captive bubble surfactometer as in Fig. 4. Each sample includes two plots, the lower plot represents minimum surface tension and the upper plot represents maximum surface tension. The phospholipase-resistant synthetic lipid/peptide surfactants were highly active in reducing minimum surface tension to values ≤1 mN/m on the captive bubble surfactometer. In addition, DEPN-8 and 9:1 DEPN-8:PG-1 also reached low minimum surface tensions on the bubble due to improved adsorption relative to glycerophospholipids. See text for details. Data are Mean ± S.E.M. for N = 3–4.