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. 1998 Aug 1;102(3):465–472. doi: 10.1172/JCI3145

Epithelial-neutrophil activating peptide (ENA-78) is an important angiogenic factor in non-small cell lung cancer.

D A Arenberg 1, M P Keane 1, B DiGiovine 1, S L Kunkel 1, S B Morris 1, Y Y Xue 1, M D Burdick 1, M C Glass 1, M D Iannettoni 1, R M Strieter 1
PMCID: PMC508906  PMID: 9691082

Abstract

We report here the role of the CXC chemokine, epithelial neutrophil activating peptide (ENA-78), as an angiogenic factor in human non-small cell lung cancer (NSCLC). In freshly isolated human specimens of NSCLC, elevated levels of ENA-78 were found that strongly correlated with the vascularity of the tumors. In a SCID mouse model of human NSCLC tumorigenesis, expression of ENA-78 in developing tumors correlated with tumor growth in two different NSCLC cell lines. Furthermore, passive immunization of NSCLC tumor-bearing mice with neutralizing anti-ENA-78 antibodies reduced tumor growth, tumor vascularity, and spontaneous metastases, while having no effect on the proliferation of NSCLC cells either in vitro or in vivo. These findings suggest that ENA-78 is an important angiogenic factor in human NSCLC.

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Selected References

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