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. 1998 Aug 1;102(3):493–498. doi: 10.1172/JCI3685

Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.

L D Asico 1, C Ladines 1, S Fuchs 1, D Accili 1, R M Carey 1, C Semeraro 1, F Pocchiari 1, R A Felder 1, G M Eisner 1, P A Jose 1
PMCID: PMC508909  PMID: 9691085

Abstract

Since dopamine receptors are important in the regulation of renal and cardiovascular function, we studied the cardiovascular consequences of the disruption of the D3 receptor, a member of the family of D2-like receptors, expressed in renal proximal tubules and juxtaglomerular cells. Systolic and diastolic blood pressures were higher (approximately 20 mmHg) in heterozygous and homozygous than in wild-type mice. An acute saline load increased urine flow rate and sodium excretion to a similar extent in wild-type and heterozygous mice but the increase was attenuated in homozygous mice. Renal renin activity was much greater in homozygous than in wild-type mice; values for heterozygous mice were intermediate. Blockade of angiotensin II subtype-1 receptors decreased systolic blood pressure for a longer duration in mutant than in wild-type mice. Thus, disruption of the D3 receptor increases renal renin production and produces renal sodium retention and renin-dependent hypertension.

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Selected References

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