Table 1.
Inclusion criteria
Subjects > 70 years of age Either gender First diagnosis of heart failure defined as: a) Mild or moderate symptomatic heart failure (NYHA calss I to III) b) An echocardiographic left ventricular ejection fraction ≥ 40% Patients who provide written informed consent |
Exclusion criteria
History and/or clinical documentation of pulmonary embolism Severe heart failure (NYHA IV or need for inotropic support) Primary valvular heart disease Pericardial disease Severe obstructive lung disease Primary pulmonary hypertension Occupational lung disease Asthma Severe renal failure (serum creatinine >2.0 mg/dL) Significant peripheral vascular disease Severe bradycardia (heart rate< 50 beats/minutes) Second or third-degree atrio-ventricular block Atrial fibrillation Life expectancy < 1 year Concern for inability of the patient to comply with study procedures and/or follow up Any condition which in the opinion of the Investigator would make it unsafe or unsuitable for the patient to participate in this study Involvement in the planning and/or conduct of the study Participation in another clinical study with an investigational product during the preceding 30 days Unable to give informed consent |