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. 2016 Apr 20;7(24):36382–36394. doi: 10.18632/oncotarget.8871

Figure 4. L-BORT treatment impairs BCR/ABL signaling and cell proliferation.

Figure 4

A. Western blotting in K562 cells exposed to L-BORT for 48 hours. B. K562 cells were treated with L-BORT for 24 hours and subjected to EMSA assays for Sp1 binding in BCR/ABL promoter using 32P-labled hBCR1/hBCR2 probes. NE, Nuclear extract. C. Western blot in K562 cells treated with L-BORT for 24 hours. D, The K562 and KU812 cells were treated with L-BORT or Tf-L-BORT for 6 hours and subjected to colony-forming assays. E. Flow cytometry assays for cell apoptosis in K562 and KU812 cells treated with L-BORT for 48 hours. The data represent three independent experiments; Data are mean ±SD; **p < 0.01, ***p < 0.001.