Table 2. Univariate and multivariate Cox regression analyses ZC3H15 for DFS or OS of patients(n=261).
| Variables | DFS | OS | ||
|---|---|---|---|---|
| Hazard ratio (95% CI)* | p Value | Hazard ratio (95% CI)* | p Value | |
| Univariate analysis | ||||
| ZC3H15(low vs high) | 1.789(1.301-2.460) | 0.0003 | 1.588(1.114-2.264) | 0.0105 |
| Gender (male vs female) | 0.950(0.583-1.549) | 0.8377 | 1.167(0.692-1.966) | 0.5624 |
| Age, years (<40 vs 40-60 vs >60) | 1.065(0.834-1.359) | 0.6156 | 0.989(0.751-1.304) | 0.94 |
| Child-Pugh Classification(A vs B) | 1.580(0.978-2.551) | 0.0614 | 1.675(0.992-2.830) | 0.0538 |
| Serum AFP, ng/ml (>20 vs≤20) | 1.405(1.025-1.927) | 0.0348 | 1.262(0.887-1.795) | 0.1959 |
| HBV (negative vs positive) | 2.347(1.332-4.136) | 0.0032 | 2.113(1.109-4.026) | 0.0229 |
| Histological grading(well vs moderate vs poorly) | 1.397(0.875-2.230) | 0.1616 | 1.219(0.726-2.046) | 0.4548 |
| Largest tumor size, cm(<3 vs 3-10 vs >10) | 1.664(1.311-2.112) | <0.0001 | 1.957(1.488-2.573) | <0.0001 |
| Presence of satellite nodules (negative vs positive) | 1.212(0.860-1.708) | 0.2719 | 1.043(0.717-1.518) | 0.8254 |
| Vascular invasion(negative vs positive) | 1.669(1.221-2.282) | 0.0013 | 1.712(1.201-2.442) | 0.003 |
| HbeAg(negative vs positive) | 1.691(1.207-2.369) | 0.0022 | 1.523(1.046-2.218) | 0.0283 |
| Tumorous number | 1.334(0.927-1.920) | 0.1212 | 1.511(1.020-2.238) | 0.0394 |
| UICC stage (I+II vs III+IV) | 1.943(1.380-2.737) | 0.0001 | 2.310(1.599-3.339) | <0.0001 |
| Multivariate analysis | ||||
| ZC3H15(low vs high) | 1.789(1.298-2.466) | 0.0004 | 1.613(1.120-2.322) | 0.0101 |
| Gender (male vs female) | NA | |||
| Age, years (<40 vs 40-60 vs >60) | NA | |||
| Child-Pugh Classification(A vs B) | NA | 2.038(1.182-3.513) | 0.0104* | |
| Serum AFP, ng/ml (>20 vs≤20) | NA | |||
| HBV (negative vs positive) | 2.494(1.378-4.517) | 0.0025 | 2.433(1.227-4.822) | 0.0109 |
| Histological grading(well vs moderate vs poorly) | NA | |||
| Largest tumor size, cm(<3 vs 3-10 vs >10) | 1.866(1.442-2.415) | <0.0001 | 2.253(1.661-3.055) | <0.0001 |
| Presence of satellite nodules (negative vs positive) | NA | |||
| Vascular invasion(negative vs positive) | NA | |||
| HbeAg(negative vs positive) | 1.641(1.161-2.319) | 0.005 | ||
| Tumorous number | NA | |||
| UICC stage (I+II vs III+IV) | 1.751(1.224-2.503) | 0.0021 | 2.365(1.601-3.492) | <0.0001 |
*
For ZC3H15, median values were used as the cut-off point for definition of subgroups (low expression and high expression groups).
Univariate analysis, Cox proportional hazards regression; Multivariate analysis, Cox proportional hazards regression; Variables were adopted in multivariate analysis for their prognostic significance by univariate analysis.