Figure 7.
Atorvastatin‐derived granulocytic myeloid‐derived suppressor cells (G‐MDSCs) attenuated the T‐cell transfer of chronic colitis. Rag1 −/− mice were injected intraperitoneally with 5 × 105 CD4+ CD45RB high T cells from C57BL/6 mice, 5 × 105 CD4+ CD45RB high T cells + 5 × 105 G‐MDSCs or 5 × 105 immature myeloid cells (IMCs) with the same phenotype from the spleens of mice after atorvastatin or vehicle treatment. Mice were killed after 8 weeks. (a) Body weight loss of mice with different treatment. (b) Colon length of mice after 8 weeks adoptive transfer. (c) Representative colon histology (100 ×) and histology score. (d) Absolute numbers of CD4+ T cells in the spleen, mesenteric lymph nodes (mLNs) and colon lamina propria mononuclear cells (LPMCs) *P < 0·05, **P < 0·01.