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Non-compartmental PK parameters of TAC TAb and ac-dmDNA31 following a single IV administration of TAC in non-infected mice.
| TAC Total Antibody |
Antibody conjugated dmDNA31 |
|||||
|---|---|---|---|---|---|---|
| PK Parameters | 5 mg/kg | 25 mg/kg | 50 mg/kg | 5 mg/kg | 25 mg/kg | 50 mg/kg |
| Cmax (nM) | 734 | 3830 | 8370 | 1230 | 6320 | 12900 |
| AUC0-inf (day • nM) | 7530 | 37290 | 59880 | 3180 | 16800 | 29000 |
| Clearance (mL/day/kg) | 4.53 | 4.59 | 5.72 | 19.9 | 18.9 | 21.8 |
| Vss (mL/kg) | 95.7 | 91.4 | 97.6 | 109 | 97.1 | 103 |
| t1/2λz (day) | 16.1 | 14.3 | 12.4 | 3.82 | 3.84 | 3.89 |
