Table 3.
Cardiovascular magnetic resonance volumetric, T1-mapping and myocardial strain data for hypertensive subjects and normotensive controls
| Hypertensive subjects (n=88) | |||||
|---|---|---|---|---|---|
| Normal indexed LVM (n=56) | Elevated indexed LVM (n=32) | ||||
| Controls (n=29) | Normal LV (n=41) | Concentric remodelling (n=15) | Concentric LVH (n=24) | Eccentric LVH (n=8) | |
| LV volumetrics | |||||
| Ejection fraction (%) | 66±7 | 67±7 | 73±7*1 | 67±7 | 54±15*2 |
| Indexed EDV (mL/m2) | 77±18 | 76±12 | 55±8*3 | 81±11 | 109±14*2 |
| Indexed ESV (mL/m2) | 27±9 | 25±7 | 15±5*3 | 29±10 | 51±21*2 |
| Indexed SV (mL/m2) | 50±11 | 51±10 | 40±7*4 | 54±9 | 58±13 |
| Indexed LV mass (g/m2) | 61±11*5 | 70±9 | 75±10 | 108±24*6 | 122±30*7 |
| Mass:volume ratio (g/mL) | 0.80±0.12*8 | 0.92±0.10*9 | 1.38±0.22*10 | 1.39±0.38*11 | 1.08±0.20 |
| T1-mapping | |||||
| Native T1 (ms) | 1024±41 | 1031±35 | 1029±45 | 1054±41*12 | 1062±41*13 |
| Extracelluar volume fraction (%) | … | 27±3 | 26±3 | 29±4*14 | 30±3*15 |
| Myocardial cell volume fraction (%) | … | 73±3 | 74±3 | 71±4*14 | 70±3*15 |
| Circumferential myocardial function | |||||
| Peak strain (%) | −17.4±2.6 | −17.6±3.0 | −17.1±3.2 | −15.5±3.1*16 | −12.8±4.6*17 |
| Peak systolic strain rate (%/s) | −101±13 | −107±28 | −115±38 | −98±20*18 | −70±20*19 |
| Peak diastolic strain rate (%/s) | 101±26 | 102±26 | 90±24 | 82±23*20 | 65±21*21 |
| Aortic function | |||||
| Compliance (mm2/mm Hg) | 2.27±1.13*22 | 1.62±1.21 | 0.99±0.70 | 1.60±1.09 | 1.27±0.72 |
| Distensibility (mm2/mm Hg ×103) | 3.48±2.14*23 | 2.26±1.71 | 1.22±0.82*24 | 1.84±1.46 | 1.28±0.72 |
*1Concentric remodelling versus Controls: p=0.002, Concentric remodelling versus Normal LV: p=0.006, Concentric remodelling versus Concentric LVH: p=0.009 and Concentric remodelling versus Eccentric LVH: p<0.0001.
*2Eccentric LVH versus Controls: p<0.0001, Eccentric LVH versus Normal LV: p<0.0001 and Eccentric LVH versus Concentric LVH: p<0.0001.
*3Concentric remodelling versus Controls: p<0.0001, Concentric remodelling versus Normal LV: p<0.0001, Concentric remodelling versus Concentric LVH: p<0.0001 and LV remodelling versus Eccentric LVH: p<0.0001.
*4Concentric remodelling versus Controls: p=0.001, Concentric remodelling versus Normal LV: p<0.0001, Concentric remodelling versus Concentric LVH: p<0.0001 and Concentric remodelling versus Eccentric LVH: p<0.0001.
*5Controls versus Normal LV: p=0.022, Controls versus Concentric remodelling: p=0.002, Controls versus Concentric LVH: p<0.0001 and Controls versus Eccentric LVH: p<0.0001.
*6Concentric LVH versus Normal LV: p<0.0001, Concentric LVH versus Concentric remodelling: p<0.0001 and Concentric LVH versus Eccentric LVH: p=0.030.
*7Eccentric LVH versus Normal LV: p<0.0001 and Eccentric LVH versus Concentric remodelling: p<0.0001.
*8Controls versus Normal LV: p=0.019, Controls versus Concentric remodelling: p<0.0001, Controls versus Concentric LVH: P<0.0001 and Controls versus Eccentric LVH: p<0.0001.
*9Normal LV versus Concentric remodelling: p<0.0001, Normal LV versus Concentric LVH: p<0.0001 and Normal LV versus Eccentric LVH: p=0.018.
*10Concentric remodelling versus Eccentric LVH: p=0.002.
*11Concentric LVH versus Eccentric LVH: p=0.002.
*12Concentric LVH versus Controls: p=0.007 and Concentric LVH versus Normal LV: p=0.023.
*13Concentric LVH versus Controls: p=0.017 and Concentric LVH versus Normal LV: p=0.042.
*14Concentric LVH versus Concentric remodelling: p=0.012.
*15Eccentric LVH versus Concentric remodelling: p=0.021.
*16Concentric LVH versus Controls: p=0.028, Concentric LVH versus Normal LV: p=0.010 and Concentric LVH versus Eccentric LVH: p=0.030.
*17Eccentric LVH versus Controls: p<0.0001, Eccentric LVH versus Normal LV: p<0.0001 and Eccentric LVH versus Concentric remodelling: p=0.002.
*18Concentric versus Concentric remodelling: p=0.037 and Concentric LVH versus Eccentric LVH: p=0.006.
*19Eccentric LVH versus Controls: p=0.002, Eccentric LVH versus Normal LV: p<0.0001 and Eccentric LVH versus Concentric remodelling: p<0.0001.
*20Concentric LVH versus Controls: p=0.007 and Concentric LVH versus Normal LV: p=0.002.
*21Eccentric LVH versus Controls: p=0.001, Eccentric LVH versus Normal LV: p<0.0001 and Eccentric LVH versus LV remodelling: p=0.024.
*22Controls versus Normal LV: p=0.019, Controls versus Concentric remodelling: p<0.0001, Controls versus Concentric LVH: p=0.033 and Controls versus Eccentric LVH: p=0.025.
*23Controls versus Normal LV: p=0.004, Controls versus Concentric remodelling: p<0.0001, Controls versus Concentric LVH: p=0.001 and Controls versus Eccentric LVH: p=0.001.
*24Concentric remodelling versus Normal LV: p=0.037.
EDV, end-diastolic volume; LV, left ventricular; ESV, end-systolic volume; LVH, left ventricular hypertrophy; LVM, left ventricular mass; SV, stroke volume.