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. Author manuscript; available in PMC: 2016 Dec 24.
Published in final edited form as: Science. 2016 Jun 24;352(6293):1570–1573. doi: 10.1126/science.aaf2729

Figure 2. Spatial and temporal expression of cranial neural crest transcription factors (TFs).

Figure 2

(A, B) Dorsal views of embryos after in situ hybridization for cranial neural crest-specific TFs reveals expression at early (A) or later (B) stages. (C) Double in situ hybridization reveals that cranial regulator Dmbx1 is expressed in the anterior neural plate border, whereas Msx1 is expressed along the entire neural axis. (D) Fate map of neural crest progenitors (red and green dots) at stage HH8- confirms cranial specific expression of Dmbx1 (purple). (E) Diagram summarizing timing of expression of early and late cranial regulators.