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. 2016 Nov 1;87(18):1925–1933. doi: 10.1212/WNL.0000000000003285

Figure 3. Parkinson disease (PD) cognition-related pattern (PDCP) expression, but not Alzheimer disease (AD)–related pattern (ADRP) expression, is associated with cognitive impairment in PD.

Figure 3

Mean PDCP (A) and ADRP (B) expression values are displayed for patients with PD with no evidence of mild cognitive impairment [MCI(−); n = 18], single-domain MCI [MCI(s); n = 30], multiple-domain MCI [MCI(m); n = 30], and PD with dementia (PDD; n = 11); values for normal controls (NL; n = 15) are provided for reference (see text). Arrows indicate post hoc Dunnett test relative to MCI(−) group. (C) ADRP' subject scores, reflecting the expression of this pattern after the exclusion of ADRP/PDRP overlap regions (see text), did not differ significantly from normal in any of the PD subgroups, regardless of cognitive status. (D) PDCP expression in this PD cohort (left) correlated significantly (r = −0.34, p = 0.001) with executive function, whereas ADRP did not correlate with summary scores for executive functioning (right) in these patients with PD (*p < 0.05, **p < 0.01, ***p < 0.001, Student t tests compared to normal controls).