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. 2016 Aug 10;41(13):3051–3059. doi: 10.1038/npp.2016.118

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Nicotine enhances extracellular dopamine levels in a subregion-specific manner. (a) Administration of nicotine selectively enhanced the extracellular concentration of dopamine in the nucleus accumbens (nAc) of nicotine-naïve rats. (b) The subregion-specific release of dopamine remained in rats subjected to 3 weeks of intermittent nicotine administration. Arrow marks time point for nicotine administration (0.36 mg/kg, subcutaneously). (c) Schematic drawing describing the areas of microdialysis probe placement in the different subregions of the striatum: (A) DLS, (B) DMS, and (C) nAc.