Table 3. A summary of DTI protocols and findings in the acute phase of cuprizone treatment.
Results past six weeks are omitted for brevity. The findings vary widely, but this is at least in part due to the different imaging protocols and treatment lengths.
| Citation | N | δ/Δ (ms) | b (s/mm2) | In-/Ex-vivo | Results |
|---|---|---|---|---|---|
| Song et al. (2005) | 6 | 4/11 | 1,600 | In | 6w:RD↑ |
| Sun et al. (2006) | 6 | 10/25 | 768 | In | 4w:AD↓, 6w:AD↓RD↑ |
| Wu et al. (2008) | 2* | * | 700 | In | 4w:AD↓RD↑ |
| Xie et al. (2010) | 6 | 8/25 | 768 | In | 4w:AD↓ |
| Zhang et al. (2012) | 6 | 3/15 | 1,000 | In | 4w:AD↓ 6w:RD↑ |
| 1,700 | Ex | 4w:FA↓RD↑, 6w:FA↓RD↑ | |||
| Chandran et al. (2012) | 30 | 3/10 | 750 | In | 5w:FA↓ |
| Thiessen et al. (2013) | 7 | 6/14 | 1,000 | Ex | 6w:FA↓AD, RD↑ |
| Guglielmetti et al. (2016) | 30 | 5/12 | 400–2,800 | In | 3w:MD, AD, RD↓, 6w:MD, AD, RD↑ |
| Jelescu et al. (2016) | 30 | 2/16 | 1,000/2,000 | In | 6w:RD↑ |
Notes:
N: Number of diffusion encoding directions.
*
Wu et al. (2008) did not report their δ/Δ values, and used two directions oriented parallel and perpendicular to the corpus callosum instead of calculating the tensor.