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. 2016 Dec 1;39(12):2161–2171. doi: 10.5665/sleep.6320

Figure 3.

Figure 3

Sleep deprivation does not affect recall of long-term memory (LTM). (A) To investigate the effects of sleep deprivation on memory recall, animals were trained early in the day at ZT 1 and then sleep deprived for the last 9 h of the night (ZT 15–ZT 24) after the window of molecular consolidation. No significant differences were observed between the training times for non-sleep deprived animals (Control Train) and sleep deprived animals (Sl Dep Train). Animals were tested for LTM 24 h after training. Trained sleep deprived animals showed a significant decrease in total response time compared to naive animals (one-way analysis of variance A F(4,35) = 25.55, P < 0.0001). Numbers of animals in each group are shown above the columns. Asterisks represent Bonferroni post hoc analyses ****P < 0.0001 for testing between naïve and sleep deprived animals and **P < 0.01 for testing between naive and non-sleep deprived animals. (B) Daytime handling did not affect recall of memory. Trained daytime-handled control animals (Hand Test) showed robust LTM with significantly shorter response compared to naïve animals (one-way analysis of variance F(2,37) = 69.79, P < 0.0001) Asterisks represent Bonferroni post hoc analyses ****P < 0.0001.