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. 1991 Mar 1;88(5):1593–1596. doi: 10.1073/pnas.88.5.1593

Eliminated chromatin of Ascaris contains a gene that encodes a putative ribosomal protein.

A Etter 1, M Aboutanos 1, H Tobler 1, F Müller 1
PMCID: PMC51070  PMID: 2000367

Abstract

Chromatin diminution in the nematodes Parascaris equorum and Ascaris lumbricoides leads to the formation of somatic cells that contain less DNA than the germ-line cells. We present molecular evidence for the coding potential of germ-line-specific DNA. We report on a cDNA clone that codes for a putative ribosomal protein (ALEP-1, for A. lumbricoides eliminated protein 1). That the corresponding gene is located in the eliminated portion of the genome indicates a difference in germ-line and somatic ribosomes of A. lumbricoides and P. equorum. Elimination of the ALEP-1 gene from all somatic cells in its fully active state may represent an alternative way to gene regulation.

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Selected References

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