FIG 8 .

A hypothetical model for the regulation of W/O conversion by Rpd3 and Rpd31. The Rpd3-containing CaRpd3L complex decorates only the upstream region of the WOR1, perhaps in cooperation with as yet unknown additional or other coregulators to deacetylate histones. The altered acetylation status regulates affinity or binding of the a1/α2 repressor and possibly Efg1, thus promoting WOR1 transcription. Conversely, the CaRpd31S complex inhibits WOR1 expression, most likely by decorating the coding region of WOR1 to inhibit intragenic transcription. The oval with symbol “?” indicates unidentified complex components.