Effect of lateral PB block (lidocaine) on the latencies of the ON-cell burst and OFF-cell pause during noxious heat (A) and stimulation with VF probes (26, 60 and 100 g, B and C). (PB injections were contralateral to the peripheral stimulus. Mean + SEM, *p < 0.05, **p < 0.01 compared to baseline using t-test for correlated means or Wilcoxon’s signed ranks test, 8 to 13 cells/group)
Statistical analysis:
Heat. Pause: t10 = 3.93, p = 0.0028, n = 11, Burst: t10 = 3.84, p = 0.0033, n = 11.
Mechanical stimulation, pause. 26 g: W = 11, p = 0.19, n = 13; 60 g: W = 78, p = 0.0005, n = 13 (with one cell silent); 100 g: W = 74, p = 0.0015, n = 13 (with one cell silent).
Mechanical stimulation, burst. 26 g: W = 10, p = 0.12, n = 8; 60 g: W = 21, p = 0.031, n = 8 (two cells active); 100 g: W = 24, p = 0.047, n = 8.