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. 2016 Nov 9;3(11):n/a. doi: 10.1002/advs.201670056

Cancer Therapy: Anti‐Metastatic and Anti‐Angiogenic Activities of Core–Shell SiO2@LDH Loaded with Etoposide in Non‐Small Cell Lung Cancer (Adv. Sci. 11/2016)

Yanjing Zhu 1, Rongrong Zhu 1, Mei Wang 1, Bin Wu 1, Xiaolie He 1, Yechang Qian 2, Shilong Wang 1
PMCID: PMC5115527

Abstract

In article 1600229, Shilong Wang, Rongrong Zhu, Yechang Qian, and co‐workers investigate the anti‐metastatic and anti‐angiogenic effects of SiO2@LDH (LDH: layered double hydroxide) loaded with etoposide (VP16). SiO2@LDH has very suitable qualities as drug delivery agent and enhances the anti‐metastatic action of VP16 both in vitro and in vivo. Enhanced anti‐angiogenic efficacy is also proven which might contribute to the anti‐cancer action. The cover image represents the 3D structure of core‐shell SiO2@LDH‐VP16, which silicon dioxide sphere flexibly enclosed by double‐layered hydroxide.

graphic file with name ADVS-3-0t-g001.jpg

Keywords: anti‐angiogenic, anti‐metastasis, etoposide, lung cancer, SiO2@LDH


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