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. 2016 Jul 13;3(7):n/a. doi: 10.1002/advs.201670035

Drug Delivery: Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems (Adv. Sci. 7/2016)

Ali Bagheri 1, Hamidreza Arandiyan 1, Cyrille Boyer 2,, May Lim 1,
PMCID: PMC5115577

Abstract

Cyrille Boyer, May Lim, and co‐workers highlight recent advances in upconversion nanoparticles (UCNPs) as NIR‐initiated controlled drug delivery systems. Surface modification strategies are reviewed alongside with the influence of the laser power intensity and illumination time on the drug release pattern in article 1500437. NIR‐to‐UV/visible UCNPs have emerged as potential remote‐controlled nanotransducers to generate in situ UV/visible light in order to activate the photoreaction of photoresponsive molecules for drug delivery applications. The cover design represents the mechanism of upconverting process by energy transfer between doped lanthanide ions in the upconversion nanoplatforms using NIR laser as excitation source and generation of UV/visible light.

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Keywords: controllable drug delivery, near‐infrared, photocleavage, photoswitching, upconversion nanoparticles


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