Figure 6. Gene set enrichment using the PrePPI interactome.
(A) To infer a function for a given protein, Q, all proteins in the human proteome, Ii, are placed in a list and sorted according to the interaction LR between Ii and Q. This list is then searched for gene sets associated with a given GO annotation enriched among the high-scoring interactors of Q. In the example in panel A, Gene Set 1 would be enriched whereas Gene Sets 2 and 3 would not be, since the proteins in those sets are either evenly distributed throughout the ranked list or clustered with proteins that are unlikely to interact with Q. (B) Histogram showing the position, in the list of enriched gene sets, of the first set associated with a known GO annotation for Q. Gene sets are ranked according to their enrichment at the top of LR-ranked list of interactors {Ii} of Q. (C) Top ranked gene sets found for two examples, BRCA2 and PEX1.