Table 3.
Reported frequency of HPV in salivary gland epithelial neoplasms in English literature
| Ref. | Tumor tested (N) | HPV detection methods primers/probe) |
HPV N (%) |
HR- HPV N (%) |
HPV16 N (%) |
HPV18 N (%) |
|---|---|---|---|---|---|---|
| Atula, 1998 [7] |
N = 34 PA (19) ACC (4) SCC (3) MEC (3) Adenocarcinoma (2) AdCC (1) EMC (1) MC (1) |
PCR (GP5+/GP6+) | 0 | N/A | N/A | N/A |
| Fischer, 2003 [8] |
SCC of parotid (1) | Nested PCR (customized primers) |
1 (100%) |
N/A | N/A | N/A |
| Vageli, 2007 [9] |
N = 8 Oncocytoma (1) ACC (1) Warthin’s tumor (1) Adenocarcinoma HG (1) PA (2) Lymphoepithelial cyst (1) PLGA (1) |
Solution PCR (GP5+/GP6+) Multiplex qRT-PCR (E6/E7 of HPV16, 18, 31, 33, 35, 52, 58 and 67) In situ PCR |
6 (75%) | 6 (75%) |
5 (63%) | 4 (50%) |
| Boland, 2012 [10] |
AdCC (n = 25) | ISH for LR- and HR- HPV |
2 (8%) | 2 (8%) | N/A | N/A |
| Descamps, 2012 [11] |
N = 79 PA (40) AdCC (15) MEC (9) CAexPA (9) ACC (6) |
PCR (GP5+/GP6+) qRT-PCR (type specific sequences) |
4 (5%) PA (3) ACC (1) |
2 (3%) PA (1) ACC (1) |
2 (3%) | 0 |
| Isayeva, 2012 [12] |
MEC (89) | Nested RT-PCR (primers N/A) IF (C1P5 antibody) |
N/A | 42 (47%) |
N/A | N/A |
| Seethala 2012 [13] |
Lymphadenoma (7) | ISH (wide spectrum HPV-DNA probe) |
0 | N/A | N/A | N/A |
| Teymoortash, 2013 [14] |
Warthin’s tumor (40) | ISH for HR-HPV PCR (GP5+/GP6+ and E1 gene regions) |
13 (33%) episomal by FISH 0 by PCR |
N/A | N/A | N/A |
| Teng, 2014 [15] |
N = 59 PA (36) Adenoma (3) Warthin’s tumor (12) Myoepithelioma (1) Adenocarcinoma (3) AdCC (1) MEC (1) Others (2) |
PCR (37 LR and HR HPV type-specific probes) |
34 (58%) |
N/A | 11 (19%) |
14 (24%) |
ACC: acinic cell carcinoma, AdCC: adenoid cystic carcinoma, CAexPA: carcinoma ex-pleomorphic adenoma, EMC: epithelial myoepithelial carcinoma, HPV: human papillomavirus, HR-HPV: high risk-human papillomavirus, IF: immunofluorescence, ISH: in situ hybridization, LR-HPV: low risk-human papillomavirus, MC: myoepithelial carcinoma, MEC: myoepithelial carcinoma, N/A: not available, PA: pleomorphic adenoma, PCR: polymerase chain reaction, PLGA: polymorphous low-grade adenocarcinoma, qRT-PCR: quantitative real-time PCR, Ref. References, RT-PCR: reverse transcriptase PCR, SCC: squamous cell carcinoma.