Table 3.
Distribution of IL28B rs12979860 genotype by region of enrolment and HCV RNA genotype
| HCV genotype | IL28B rs12979860 genotype | p valuea | ||
|---|---|---|---|---|
| CC | CT | TT | ||
| G1 (n = 1702) | ||||
| Asia (n = 25) | 16 (64.0) | 9 (36.0) | 0 (0.0) | |
| Europe (n = 1251) | 388 (31.0) | 680 (54.4) | 183 (14.6) | |
| Middle East (n = 289) | 65 (22.5) | 167 (57.8) | 57 (19.7) | |
| Latin America (n = 137) | 31 (22.6) | 74 (54.0) | 32 (23.4) | |
| Total (n = 1702) | 500 (29.4) | 930 (54.6) | 272 (16.0) | <0.0001 |
| G2 (n = 323) | ||||
| Asia (n = 6) | 4 (66.7) | 2 (33.3) | 0 (0.0) | |
| Europe (n = 291) | 111 (38.1) | 144 (49.5) | 36 (12.4) | |
| Middle East (n = 19) | 7 (36.8) | 12 (63.2) | 0 (0.0) | |
| Latin America (n = 7) | 4 (57.1) | 2 (28.6) | 1 (14.3) | |
| Total (n = 323) | 126 (39.0) | 160 (49.5) | 37 (11.5) | 0.3572 |
| G3 (n = 574) | ||||
| Asia (n = 105) | 45 (42.9) | 52 (49.5) | 8 (7.6) | |
| Europe (n = 432) | 177 (41.0) | 200 (46.3) | 55 (12.7) | |
| Middle East (n = 30) | 8 (26.7) | 20 (66.7) | 2 (6.7) | |
| Latin America (n = 7) | 2 (28.6) | 5 (71.4) | 0 (0.0) | |
| Total (n = 574) | 232 (40.4) | 277 (48.3) | 65 (11.3) | 0.2041 |
| G4 (n = 260) | ||||
| Asia (n = 0) | 0 | 0 | 0 | |
| Europe (n = 128) | 37 (28.9) | 64 (50.0) | 27 (21.1) | |
| Middle East (n = 127) | 53 (41.7) | 62 (48.8) | 12 (9.4) | |
| Latin America (n = 5) | 2 (40.0) | 3 (60.0) | 0 (0.0) | |
| Total (n = 260) | 92 (35.4) | 129 (49.6) | 39 (15.0) | 0.0467 |
aPearson’s Chi square test for differences in IL28B rs12979860 genotype by variables