Figure 2.
The photothermal effects of DTSL, ITSL or DITSL and heating-induced DOX release from DITSL. (A) The temperature profiles of PBS, DTSL, ITSL and DITSL dispersions under the irradiation of 808 nm laser. (B) The peak temperature maps were recorded with an infrared thermal imaging camera. (C) Schematic diagram of DOX release from DITSL under NIR-laser irradiation. The liposome membrane temperature would increase when the NIR-laser irradiation was applied. Destruction of liposome membrane occurs when the liposome membrane temperature achieves 42 °C. (D) The cumulative release of DOX from DITSL at 37 °C, 42 °C or 50 °C. (E)The cumulative release of DOX from DTSL or DITSL under the NIR-laser irradiation at a power intensity of 0.8 W/cm2 for different time (0-5min). The cumulative release of DOX from DITSL without irradiation was also examined as a control. (F) The effects of irradiation-nonirradiation sequence number of 0 time, 1 time, 2 times or 3 times on the released DOX from DITSL with 808 nm laser (0.8 W/cm2, 2-min). Data represents the mean ± standard deviation of triplicate measurements.