Figure 5.

AR-PAM imaging of breast cancer in vivo. (A) Schematic diagram of the AR-PAM system. OPO: optical parametric oscillator; NDF: neutral density filter; BS: beam splitter; PD: photodiode; FC: optical fiber coupler; PA: photoacoustic; US: ultrasound; ConL: convex lens. (B) Three-dimensional ultrasound (US), PA, and their overlay images of the tumor region before and 24 hours after the injection of non-targeted ICG-PLGA-lipid nanoparticles and targeted FA-ICG-PLGA-lipid nanoparticles, respectively. Figure adapted with permission from ²⁶.