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. 2016 Nov 15;4:e2692. doi: 10.7717/peerj.2692

Figure 1. Domain architecture of vertebrate SRs relevant to this study.

Figure 1

All SR sequences are anchored in the membrane with one or two transmembrane domains. All have very short cytoplasmic tails and extensive extracellular ligand-binding domains. SR-As contain a collagen domain(s) and can include an SRCR or a CTLD. SR-Bs have two cytoplasmic tails on either side of a CD36 domain that forms an extracellular loop. SR-Es are defined by the presence of a CTLD. SR-Is have multiple SRCR repeats and no other identifiable extracellular domains. C, carboxy terminus; CTLD, C type lectin domain; LOX1, lectin-like oxidized low density lipoprotein receptor 1; MARCO, macrophage receptor with collagenous structure; N, amino terminus; SRCL, scavenger receptor with C-type lectin; SRCR, scavenger receptor cysteine-rich domain.