Table 2.
DCK, RRM1 and RRM2 Expression by Immunohistochemistry in Pancreatic Cancer
| DCK Protein Expression | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Author | Year | Gemcitabine | Non-Gemcitabine | Antibody | IHC | Scores Used | TMA | Treatment Design | O.S. association with DCK |
| Farrell | Current | 88 | 98 | Rabbit Polyclonal | Semiquant | Cyto only | Yes | Prospective Randomized | No |
| Sebastiani | 2006 | 44 | 0 | Rabbit Polyclonal | Semiquant | No | Retrospective Non Randomized | Yes/p=0.04 (UniVar) | |
| Marechal | 2010 | 45 | 0 | Rabbit Polyclonal | Semiquant | Cyto only | Yes | Prospective Non Randomized | Yes/p=0.002 |
| Marechal | 2012 | 243 | 49 | Rabbit Polyclonal | Semiquant | Cyto only | Yes | Retrospective Non Randomized | Yes/p=0.012 |
| RRM1 Protein Expression | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Author | Year | Gemcitabine | Non-Gemcitabine | Antibody | IHC | Scores Used | TMA | Treatment Design | O.S. association with RRM1 |
| Farrell | Current | 92 | 104 | Rabbit Polyclonal | Quantitative | Nuclear | Yes | Prospective Randomized | No |
| Fisher | 2012 | 74(33)* | 0 | Rabbit Polyclonal | Semiquant | Cyto and Nuclear | No | Retrospective Non Randomized | No |
| Marechal | 2012 | 243 | 49 | Rabbit Polyclonal | Semiquant | Nuclear | Yes | Retrospective Non Randomized | No |
| Valsecchi | 2012 | 82 | 0 | Rabbit Polyclonal | Semiquant | Cytoplasmic | No | Retrospective Non Randomized | No |
| Nakagawa | 2012 | 109 | 0 | Rabbit Polyclonal | Semiquant | Nuclear | Yes | Retrospective Non Randomized | Yes/p=0.019 |
| Akita | 2009 | 28 | 40 | Rabbit Polyclonal | Quantitative | Nuclear | Yes | Retrospective Non Randomized | Yes/p=0.0010 |
| RRM2 Protein Expression | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Author | Year | Gemcitabine | Non-Gemcitabine | Antibody | IHC | Scores Used | TMA | Treatment Design | O.S. association with RRM1 |
| Farrell | Current | 88 | 101 | Rabbit Polyclonal | Semiquant | Cytoplasm | Yes | Prospective Randomized | No |
| Xie | 2012 | 44 | 0 | Goat polyclonal | Semiquant | Nuclear | Yes | Retrospective Non Randomized | No |
| Fisher | 2012 | 74(33)* | 0 | Mouse monoclonal | Semiquant | Cyto and Nuclear | No | Retrospective Non-Randomized | Yes/p=0.02 |
*
33 of the reported 74 patients definitely received gemcitabine
IHC, immunohistochemistry
Semiquant, semiquantitative
Cyto, cytoplasm
TMA, tissue microarray
O.S., overall survival