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. 1991 Mar 15;88(6):2307–2311. doi: 10.1073/pnas.88.6.2307

Transcript elongation and termination are competitive kinetic processes.

P H von Hippel 1, T D Yager 1
PMCID: PMC51220  PMID: 1706521

Abstract

In this paper, we develop a kinetic approach to predict the efficiency of termination at intrinsic (factor independent) terminators of Escherichia coli and related organisms. In general, our predictions agree well with experimental results. Our analysis also suggests that termination efficiency can readily be modulated by protein factors and environmental variables that shift the kinetic competition toward either elongation or termination. A quantitative framework for the consideration of such regulatory effects is developed and the strengths and limitations of the approach are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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